By learning from evolution, we make steps towards combinatorial #polyketide biosynthesis!🦠 This week, we report in Science Magazine a general strategy for engineering trans-AT PKSs. Why do we think this is important (💊) and how did we do this? A thread 🧵science.org/doi/10.1126/sc…

Our latest work for lydicamycin biosynthesis using GNPS.

Dissecting the biosynthesis of the polyketide alkaloid lydicamycin using a complex metabolic network - now published in New Journal of Chemistry pubs.rsc.org/en/content/art…

Glad to see our latest work has been published by the newly established RSC journal, Digital Discovery.

A deep learning model for type II polyketide natural product prediction without sequence alignment - now published in Digital Discovery pubs.rsc.org/en/content/art…

Congratulations Saket Rahul Bagde on passing your B-exam! Saket’s PhD work investigated how the TRAPPII complex activates Rab11 and how the polyketide synthase Lsd14 makes the antibiotic Lasolocid A

#SAUFaculty Dr. Priti Saxena from FLSB, presented an e-poster titled 'Functional Flexibility of Mycobacterium marinum Type III Polyketide Synthases and Modifying Enzymes' and secured First place in the best poster awards at the International Symposium on 'Innovative Approaches in

Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides nature.com/articles/s4146…

A resource for the in silico identification of fungal polyketide synthases from predicted fungal proteomes eurekamag.com/research/051/2…

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
セリンとの共有結合狙うなら確かにシアノだけど、プロテアーゼ以外で積極的にそれやるの面白い pubs.acs.org/doi/10.1021/ac…

#Evolution -guided engineering of trans-acyltransferase polyketide synthases.

This study shows #engineering enzymes can diversify natural products, creating 22 new functional polyketide synthases. This method opens avenues for producing complex #therapeutic compounds.

Detection of polyketide synthase and nonribosomal peptide synthetase biosynthetic genes from antimicrobial coral-associated actinomycetes eurekamag.com/research/052/5…

Analysis of subunit interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus eurekamag.com/research/015/0…

Liam has just taken the stage, detailing some polyketide biosynthesis and work on natural product biosynthetic pathways in the Crump group. All speakers have done a brilliant job so far this morning!

Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin nature.com/articles/s4146…

Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis biorxiv.org/cgi/content/sh… #biorxiv_biochem

A great look by Maria and team at elusive structures of polyketide synthases. Very useful for those engineering these enzymes!

Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis eurekamag.com/research/004/4…

Team Microbiology_ETH headed by Jörn Piel & collaborators show that the heterocomplex of the OocP halogenase and its helper protein OocQ catalyze the radical chlorination of a complex polyketide backbone and present the crystal structure of this complex

doi.org/10.1016/j.str.…

Profiling Expression Strategies for a Type III Polyketide Synthase in a Lysate-Based, Cell-free System
doi.org/10.1101/2023.1…

Our latest work reveals the inhibitory effects of the polyketide lydicamycin on weed growth.

A Streptomyces species from the ginseng rhizosphere exhibits biocontrol potential academic.oup.com/plphys/article…

A quest to build new antibiotics,Chaitan Khosla studies a kind of molecule-making assembly line, polyketide synthases, that's responsible for making antibiotics like erythromycin. Knowing how these assembly lines work will allow scientists to engineer them to make new antibiotics