Pre-print alert 🚨! Two studies on the #biosynthesis of the bacterial #meroterpenoids phenalinolactone and atolypene. Here’s the first on the diterpenoid PLA, led by Tyler Rudolf Lab in collaboration with Sandra Loesgen (loesgenlab.bsky.social) and Liaobin Dong. doi.org/10.26434/chemr…. UF Chemistry

Two Cytochrome P450 #Enzymes Form the Tricyclic Nested Skeleton of Meroterpenoids by Sequential Oxidative Reactions by E. Yang, Y. Yao, H. Su, Z. Sun, S.-S. Gao, S. Sureram, P. Kittakoop, K. Fan, Y. Pan, X. Xu, Z.-H. Sun, G. Ma, G. Liu in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Interested in natural product biosynthesis? Working on tailoring enzymes but frustrated by the lack of a dedicated repository? Us too! That’s why we created MITE – the Minimum Information about a Tailoring Enzyme doi.org/10.26434/chemr…

Congrats to Hengqian, Chunshuai, and the team for discovering and characterizing a novel bioactive RiPP-fatty acid hybrid molecule (nature.com/articles/s4155…). This work has opened a new avenue for finding novel bioactive RiPPs (igb.illinois.edu/article/resear…).

Exciting things come from Nature, great collaborations, and grit! Preprint up: Leptochelins - a story of geographically dispersed cyanobacteria producing a suite of stunning compounds with high copper resilience, beautiful BGC, and anticancer potential!🌊 doi.org/10.26434/chemr…

Pleased to share our new ACS Synthetic Bio paper on minor #cannabinoid bioproduction and #biocatalysis led by Anna Love and Trevor Purdy and supported by NIH NCCIH pubs.acs.org/doi/full/10.10…

An exciting day in Rudolf Lab! Tyler defended his PhD on bacterial terpene biosynthesis and enzymology in style! Tyler has been a joy to have in lab and accomplished A LOT. #ProudPI UF Chemistry

Just published a book chapter on fungal meroterpenoid cyclases in Methods in Enzymology. sciencedirect.com/science/articl…

Excited to share our new paper out in Methods in Enzymology! We provide a protocol for the study of membrane-bound terpene synthases using a precursor overproduction system in E. coli. Rudolf Lab sciencedirect.com/science/articl…

Excited to unveil the first insights into dolastatin 10 biosynthesis. Thanks to all authors, the Luesch, Paul, Bruner Lab labs, and RM1 and R35 NIGMS.
Biosynthesis of Dolastatin 10 in Marine Cyanobacteria, a Prototype for Multiple Approved Cancer Drugs pubs.acs.org/doi/10.1021/ac…

🪲🦠Our latest paper is out on biorxiv! We looked at the evolution of antifungal-producing symbionts in a group of beetles, finding beetles repeatedly acquired different bacteria that make the same compound! 🧪 Pls RT! biorxiv.org/content/10.110…

Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors by Torben Rogge, Qingyang Zhou, Nick Porter, Frances Arnold at Caltech Chemistry & Chemical Engineering, and Ken Houk at UCLA Chem & Biochem in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

I had a wonderful experience hosting an ASP SuRF student last summer and would love to do so again.

If you're an eligible undergraduate and are interested in what our lab does, reach out to me and let's put in an application together!

Everyone else, please RT and share widely!

Online now! Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria by Nicholas C. Poulton, Jeremy Rock Rock Lab 🧬🧫, and colleagues at Rockefeller University dlvr.it/T1mj1Z #chembiol

Our newest paper on biocatalytic stereoselective oxidation of 2-Arylindoles is out! Congratulations to Sarah Champagne and the flavins team, Chad , Philipp Gemmel, and Charles Brooks (he/him)! Go Champase, Go!
#BioCats #GoBlue

pubs.acs.org/doi/full/10.10…

Online! Rebecca Butcher lab UF Chemistry use metabolomics to demonstrate how bacterial food impacts the production of the pheromone ascaroside and identify an acyl-CoA thioesterase required for its biosynthesis in C. elegans dlvr.it/T10h1v

Looking for the ideal CRISPR-Cas system for your experiment? CasPEDIA, our wiki of Cas nucleases, introduces a new functional nomenclature (CasID) to help you get started!
Caspedia.org

Are you running antiSMASH across many genomes? Check out multiSMASH, my simple wrapper that streamlines comparative BGC analyses by parallelizing antiSMASH runs and tabulating the results. Runs BiG-SCAPE too! WIP, so feedback and bug reports appreciated.
github.com/zreitz/multism…

Formation of Bridged Disulfide in Epidithiodioxopiperazines (W.-B. Yin et al.) University of Chinese Academy of Sciences onlinelibrary.wiley.com/doi/10.1002/cb…

Figure 7 shows the evolutionary history of PKS/FAS KSs across nature, suggesting an ancestral PKS diverged into what is now FAS biosynthesis.

Absolutely wonderful work from the Schmidt lab.
nature.com/articles/s4146…