ChatGPT understands the meaning of life, the universe, and everything 😂

Not so simple IMO!

* Potential adverse effects on finances & well-being

* PRS modest discrimination for CVD, BP, lipids, BMI, T2D beyond standard clinical data

* Many PRS scores for each & agreement isn't great. Many folks will be in top 5-10% of 1 score but not another

Even…

😂

Results for #ACC24 STEP-HFpEF DM Trial

Baseline medication use in the trial. Why are OVER 80% of pts with HFpEF on beta blocker when we know this worsens symptoms?

In a new paper in Nature Genetics, scientists from MRC Epidemiology Unity, University of Cambridge, report a new obesity gene--BSN (nature.com/articles/s4158…). Loss of function mutation in BSN causes an extreme form of obesity that is reminiscent of the weight gain associated with…

Important thoughts on interatrial shunt for HF from Sanjay Kaul 👇

JAMA Assoc Editor Dr. Khera chats with our University of Michigan faculty panelists; Venk Murthy MD PhD Rada Mihalcea Michael Sjoding! Great conversation so far 🎤 #UMPrecisionHealth U-M IHPI UM-MiCHAMP University of MichiganCHOPFellow eHAIL

Two great docs!

No, tSNE/UMAP don't 'preserve neighborhoods'.
Fig 2d shows that tSNE and UMAP get the large majority of k nearest neighbors wrong on all datasets. And this is 'recall' not even of true cell positions but just the logp1 mappings of the raw data!

Back in Nov 2023, safety concerns led me to suggest stopping trials of $VERV's VERVE-101 gene therapy for PCSK9.

Today the company did so.

Good decision!

Even better to start with rare diseases for which there are no other treatments rather than diseases where there are several safe monthly or twice years meds with similar efficacy.

My thoughts here from a few months back:

venkmurthy.substack.com/p/editing-the-…

Poorly parallelized: It looks like only a single thread...

Important study by Krishna Patel and colleagues in Journal of Nuclear Cardiology: Balanced ischemia is rarely missed with stress PET.

Much of prior literature on this influenced by SPECT without attenuation correction, which unfortunately is still frequently used.

PET MPI is even better with…

The original multithreading.

I'm always hesitant to use use terms like game changer, but these are the three trials that could have the greatest impact on practice of cardiology, depending on results. Nice summary by John Mandrola, MD

sensible-med.com/p/modern-cardi…

Important learning case re cardiac sarcoid PET 👇

49-year-old with frequent VEs underwent rest Rb-82 imaging and 24-hr. carbohydrate-restricted diet for F-18 FDG PET to exclude cardiac sarcoidosis. Beta-hydroxybutyrate level < 0.2 mmol/L (normal > 0.3 mmol/L). What is your interpretation? Vote below.

Note to SPECT technologist: please check center of rotation

arstechnica.com/science/2024/0…