#GUTAbstract by Yu et al on the paper

'Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss' via bit.ly/3vGR0IY

Paper: bit.ly/4akU3Wz

Jing Ying #HBV #HepatitisB

Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types - Genentech Adaptive Biotech go.nature.com/3M3zoMf

New #JITC article: Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma bit.ly/3S50JSc Jing Ying

16 databases of scRNAseq datasets. 👇 🧵 Reuse them! #singlecell #bioinformatics

Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1 Nature Rev Immunol Honjo
nature.com/articles/s4157…

🥼 This Cancer Cell study by scientists at the NCI Center for Cancer Research (@theredmanMD, @gulleyj1, Dr. Pat Soon-Shiong & more) and collaborators illustrates the physiological and metabolic changes underlying #Tcell responses to neoadjuvant #immunotherapies .

📘: bit.ly/41PtqUR

Advancing CAR T cell therapy through the use of multidimensional omics data NatureRevClinOncol

nature.com/articles/s4157…

This study of 771 ipilimumab-nivolumab-treated melanoma patients shows worse PFS+OS for patients whose irAEs were treated with second-line immunosuppression compared to those managed with steroids only, irrespective of type of second-line immunosuppression ja.ma/3Ps48ax

Rational combinations of targeted cancer therapies: background, advances and challenges

*Highly* comprehensive review!! Critical reading to understand targeted therapy resistance mechanisms & how drug combinations can be identified to combat resistance.

nature.com/articles/s4157…

Two super exciting papers in Cell today looking at #fungi across multiple human #cancer types, thus expanding insights into the #tumor #microbiome - Straussman_Lab Knight Lab bit.ly/3RoLQGj and Iliev Lab Anders B. Dohlman, PhD bit.ly/3fodaHr #TCGA Cell

Now online in Cancer Discovery: Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell #Immunotherapy against Cancer Marco Ruella Ruella Lab Penn Medicine aacrjournals.org/cancerdiscover…

ICYMI: Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells bit.ly/3zhERb6 Rong Fan Zhiliang Carl June

Sex and cancer immunotherapy: Current understanding and challenges dlvr.it/STngYM

Thrilled to share our journey using single-cell multi-omics to do deep immunophenotyping in patients with ICI myocarditis

Circulation #CardioOnc Sean M Wu, MD PhD Single Cell Media

ahajournals.org/doi/10.1161/CI…

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.
Now out online including this cool 'cover art' by Cancer Discovery ! cancerdiscovery.aacrjournals.org/content/early/…

'Immune-related adverse events and the balancing act of immunotherapy'

Check out our new article in Nature Communications highlighting future directions in the study of irAEs from cancer immunotherapy, by stellar fellow Michael Conroy Beaumont RCSI Cancer Centre

rdcu.be/cFhKO