Which of the different spatial transcriptomics (ST) technologies should you use for your research? The lessons we have learnt from comparing RNAscope, Molecular Cartography (MC), Merscope, Xenium and Visium are now on bioRxiv doi.org/10.1101/2024.0… 🧵

Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various clinically relevant tasks Faisal Mahmood Harvard Medical School
nature.com/articles/s4159…

STCellbin

Use Nuclei+Cell Membrane/Wall stains to improve #CellSegmentation & single-cell-resolved #SpatialTranscriptomics

Tailored for #StereoSeq , but likely implementable for other ST methods

Susanne Brix & Xun Xu labs GigaByteJournal 2024
gigabytejournal.com/articles/110

Congrats Lee Grimes Lab Nathan Salomonis Annie Song Cincinnati Children's
Integrating ‘-omics’ datasets with machine learning yields high-resolution map of primary human bone marrow hematopoietic progenitor cells Nature Immunology
nature.com/articles/s4159…

'All fibroblasts are equal, but some are more equal than others'
A review in NatRevRheumatol reveals that programming of certain joint cells can influence their response to inflammation, resulting in variations in #Arthritis impact & treatment efficacy
➡️doi.org/10.1038/s41584…

Huge thanks European Respiratory Society ERS!

Loved being part of this #ILD webinar with Pilar Rivera-Ortega PA Juge maria molina molina Katerina Antoniou #philippeCamus

Plenty of Rheum in Resp 😊

Organoids of multiple different tissue types can be generated from cells collected from amniotic fluid samples, without termination of the pregnancy, according to a study in Nature Medicine. go.nature.com/4c5oMrV

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients dlvr.it/T46gDM

⭐Research highlight: MEGA is a new #CRISPR based RNA-editing platform that can be used to enhance the fitness of #CARTcells ; it may also overcome certain limitations of conventional DNA-targeting CRISPR–Cas9 systems. Cell
nature.com/articles/d4159…

Promises and challenges of organoids: From humanized to human derived dlvr.it/T3zljp

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer dlvr.it/T3zLZH

NatRevRheumatol highlighting our paper😍So exciting! Thanks Adam Croft and chrissyb for this very nice article👏 the original paper can be found here👉
nature.com/articles/s4146…

New content online! All fibroblasts are equal, but some are more equal than others dlvr.it/T3x52W

Great work chrissyb on a brilliant paper by Caroline Ospelt and team! RACE GBN Birmingham Rheumatology Research Group Inflammation and Ageing

Why do the different types of inflammatory arthritis affect distinct joints in people? Why doesn’t the immune system attack the elbows, the knees and the fingers indiscriminately? We reviewed an article by Elhai and colleagues. A🧵
(With thanks to Adam Croft Birmingham Rheumatology Research Group )

Research has a hugely positive impact on the treatment of arthritis. Funding research gives people living with the condition hope for the future.

Like AMRC, we're thrilled by the announcement of £45m for charity-funded early career researchers. Together, we can improve lives.

Only one day to go until Prof Adam Croft's inaugural lecture! Join to learn all about fibroblasts and their role in #inflammation .

Register below 👇

In a study published in The Journal of Translational Medicine yesterday, our #PhenoCycler technology was successfully utilized to analyze the immune cell composition and spatial characteristics within #nonsmallcelllungcancer ( #NSCLC ) tissues from a retrospective immune checkpoint…

Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer | Nature Genetics
nature.com/articles/s4158…

#CancerResearch

You're invited to the inaugural lecture of Prof Adam Croft on 6th March, entitled 'Restoring order to the joint: fibroblasts as cellular checkpoints of inflammation'.

Hear more from Adam below. Attend in person or online: birmingham.ac.uk/university/col… Inflammation and Ageing Uni of Birmingham