9/ We would like to dedicate this study in loving memory of our friend & colleague Timothy Hoang. He made crucial contributions to the fields of HIV cure & SARS-CoV-2 research during his short but impactful career & is remembered for his drive, intelligence, and love of science.

5/ In vivo, IFNmod treatment resulted in a 1-3 log-fold reduction in viral load in the airways of SARS-Cov2 infected RMs.

6/ Bulk RNA-Seq profiling of BAL, PBMC, and whole blood showed that ISG expression was downregulated in IFNmod-treated RMs along with a potent attenuation of systemic inflammation and inflammasome activation in lower airways.

7/ scRNA-Seq showed that IFNmod treatment inhibited accumulation of CD163+MRC1- macrophages & reduced the expression of inflammatory mediators in this subset in BAL. Downregulation of genes related to inflammasome activation, stress response, and cell death was observed in lungs.

Ann Chahroudi MD, PhD Emory LGS Emory University IAS - the International AIDS Society Emory CFAR Emory Dept of PEDS Ann Chahroudi MD, PhD Steve Bosinger spelling out I-A-S after a wonderful conference Day 2 covering more pediatric & cure work IAS - the International AIDS Society #IAS2023

IAS - the International AIDS Society IAS 2023 is off to a wonderful start! Many thanks to the Scholarship Committee and IAS for uniting collaborators (normally a few states away) down in the Southern Hemisphere!

Figure 1. Folks from lab of Ann Chahroudi MD, PhD, Dr Hannah King, and Michelle from Steve Bosinger

Join us for a new course offering this October. Registration is limited so be sure to sign up soon.

New primate research by Elise Viox and colleagues from Steve Bosinger and Mirko Paiardini corroborates the theory that too little IFN-I exacerbates viral infection, while too much IFN-I leads to harmful immune hyperactivation. scim.ag/3zF

A new study in animals evaluates how the presence of anti-viral interferon-I (IFN-I) and related signaling affects #SARSCoV2 outcomes. Elise Viox Steve Bosinger Mirko Paiardini

Learn more: scim.ag/3yf

Our new work with Mirko Paiardini and Elise Viox by Amit Upadhyay featured by Science Immunology

Protective immunity sits on the precipice of pathology. Out Science Immunology, Elise Viox and colleagues Mirko Paiardini and Steve Bosinger investigated the role of IFN-I in restraining viral replication and contributing to disease in a SARS-CoV-2 infection model.

Proud of our multidisciplinary work with Cheryl Maier Ortlund Lab and friends Emory School of Medicine Guido Silvestro DM Steve Bosinger Deanna Kulpa Ann Chahroudi MD, PhD showing that in severe COVID19, red cells aggregate like crazy, to the point of endothelial damage - Rouleaux formation gone wild!

Deep analysis of infant #immune responses to #SARSCoV2 (omicron) #proteomics #multiomics
From team including our collaborators: Alessandro Sette Alba Grifoni Yupeng Feng Steve Bosinger Purvesh Khatri Bali Pulendran, and others.
Cell
cell.com/cell/fulltext/…

Mirko Paiardini Science Immunology Steve Bosinger Elise Viox Timothy Hoang Amit Upadhyay Congratulations 👏👏👏

Jo-Ann Passmore Thank you JoAnn!

Don’t miss the latest from #EmoryCFAR Members, Elise Viox, Steve Bosinger & Mirko Paiardini which is featured in Science Immunology. Congrats to all!!

10/ We would like to thank all of our wonderful collaborators and the funding sources that made this study possible.

8/ Based on these results, we conclude that although IFN-I is beneficial in controlling SARS-CoV2 replication, excessive uncontrolled inflammation driven by IFN-I-signaling plays an important role in SARS-CoV2 pathogenesis.

Administration of a mutated IFN-α2 to rhesus macaques limited viral replication and pathogenesis during SARS-CoV-2 infection Elise Viox Steve Bosinger Mirko Paiardini Science Immunology
science.org/doi/full/10.11…