1/Thrilled to share our newest findings on peripheral priming of circulating neutrophils upon bacterial infection and sterile inflammation in humans!

science.org/doi/full/10.11…

Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus: buff.ly/3ToouUb

Lisa Zaba MD PHD Purvesh Khatri Stanford Medicine
#Vaccines

Congratulations to the SAVE-MORE study authors for demonstrating the promise of #endotypes to differentiate treatment response. This study described #sepsis endotype dynamics over 7 days in COVID-19 pneumonia patients treated with anakinra.
ccforum.biomedcentral.com/articles/10.11…

Interesting update on curr thinking in #sepsis immunobiology. Most notable is still lack of direct link between mechanisms and subtypes, or consensus on subtypes... but we're getting closer! SUBSPACE may help with the latter... fun times ahead! Purvesh Khatri Angela Rogers

One would also think how did this get past the editors in the first place. But sadly I have first-hand experience in how editors have no control over what goes out for review. That's why I and virtually the entire editorial board from the systems immunology section resigned

Another (excellent) study showing our 3-gene #HostResponse panel for TB is accurate in multiple settings! If you want generalizable results, start with broad data! Purvesh Khatri

In The Lancet: host response can PREDICT secondary bacterial infection at presentation! tinyurl.com/7mnjfxru

We have shown who will get infected upon exposure to influenza (tinyurl.com/bdd8wews).

These results SUGGEST host response may predict susceptibility to infection

We are hiring for a Research Program Coordinator to help lead solutions-oriented projects in global infectious diseases. Please share! careersearch.stanford.edu/jobs/research-…

I hope you know the answer to yesterday's 'Bad Blood for $600' question on the popular show Jeopardy!

This tour de force is a result of lot of hard work from Kalani Ratnasiri. It started almost 10 years ago with 3 viruses, that has now expanded to include 31 viruses across species. Previous work: doi.org/10.1016/j.immu… and doi.org/10.1016/j.immu…

At Peter M. Cahill today? Learn about the power of the host response in diagnosing infections from Inflammatix co-founder and Stanford Medicine's Purvesh Khatri in Track 3: Infectious Disease and Microbiome
#diagnostics #sepsis #infectiousdiseases

How much can 85 nts of #RNA compute? Every 2-input logic gate, ratios, & a 3-gene score for active tuberculosis GBP5*DUSP3/KLF2^2. #openscience crowdsourcing.
doi.org/10.1101/2024.0…
Stanford Medicine @HHMINews Gates Foundation Christian Choe Eterna Purvesh Khatri William J. Greenleaf

Vinay Tummarakota Wow, these numbers are eye-popping. And there's that survivor bias:

Purvesh Khatri, PhD, used to hate biology. Now, he's a bioinformaticist who uses data to reveal and predict how the human immune system works and how it will act when confronted with disease or infection: stan.md/3n7whda
#Immunology #Bioinformatics #2023Recap

Delighted to share that we received the US U.S. FDA 'Breakthrough Device' designation, which provides for priority review and therefore faster path to patients:

linkedin.com/posts/inflamma…

We’re thrilled to receive FDA BDD for our lead product, TriVerity! The ability to quickly and accurately both diagnose and prognose patients with suspected sepsis would be a game changer.

So proud of our team for this huge milestone!

A decade in the making! Congratulations to my co-founders Tim Sweeney Jonathan Romanowsky and the fantastic team Inflammatix that made this possible (way too many people to list in a tweet, but you know who you are)

Deep analysis of infant #immune responses to #SARSCoV2 (omicron) #proteomics #multiomics
From team including our collaborators: Alessandro Sette Alba Grifoni Yupeng Feng Steve Bosinger Purvesh Khatri Bali Pulendran, and others.
Cell
cell.com/cell/fulltext/…

Achieving this TriVerity Test development milestone gets us closer to bringing precision medicine to acute care.
The TriVerity Test is not for sale, and does not have marketing approval or clearance from regulatory authorities in any jurisdiction.
prnewswire.com/news-releases/…

10 years to the quarter! From a hypothesis to a device able to measure our (really, any) host response-based tests at point-of-care from sample-to-answer in 30 minutes! Congratulations to team Inflammatix! Too many people to list in a tweet, but my eternal gratitude!