The conclusion of #HOT_COVID_trial was
In adult ICU patients with COVID-19 and severe hypoxemia, targeting a Pao2 of 60 mm Hg (8 kPa) resulted in more days alive without life support in 90 days than targeting a Pao2 of 90 mm Hg (12 kPa)

Not that we hope to see COVID pts in ICU

The effect of the primary outcome was supported by sensitivity analyses and those of secondary outcomes

Primary outcome - days alive wo life-support at 90 days - was
80.0 days in the lower O2-target group vs.
72.0 days in the higher group (P = .009; bootstrapped adjusted mean difference, 5.8 days [95% CI, 0.2-11.5 days])

There were no meaningful sub-group differences in effect

The protocol, i.e., lower vs higher oxygenation targets while in ICU, separated the 2 allocation groups

Of the 726 pts randomised most patients were analysed

69% were males
Age 65 years
24% on invasive ventilation
13% on non-invasive
Most with P/F-ratios < 100
Randomisation occured 3 hours after ICU admission

#HOT_ICU_trial was swiftly transformed to #HOT_COVID_trial planned to enrol 780 pts

The trial was terminated early after the winter 22-23 and the omicron variant because of very few pts in ICUs with severe hypoxemia

At that time 726 patients had been enrolled

It started out by the observation in the #HOT_ICU_trial
that the 100 pts enroled with #COVID_19 had benefits from the lower vs. higher oxygenation target (published as a post-hoc analysis
onlinelibrary.wiley.com/doi/epdf/10.11…

Massiv effort from alot of good people 🙏
Aalborg Universitetshospital Bodil S. Rasmussen Thomas Lass Klitgaard
Olav Lilleholt Schjørring
UCPH Healthscience Theis Lange
Rigshospitalet Maj-Brit N Kjær Anders Perner

Staff, patients & relatives in 11 ICUs in 🇩🇰🇳🇴🇨🇭
Funded by Uddannelses- og Forskningsministeriet

Handled well by Christopher Seymour JAMA

HOT of the press
#HOT_COVID_trial on
Lower vs Higher Oxygenation Target and Days Alive Without Life Support in ICU patients with COVID-19 and severe hypoxemia jamanetwork.com/journals/jama/…

Tomorrow, I will defend my PhD. Everyone is welcome! Should be available online by joining the team-meeting but tech-support is low🍀

The ICU at University Medical Center Groningen in the Netherlands has now been initiated and ready to include patients in the GODIF trial.
Congratulations and welcome to the GODIF team 👏🏻 #GODIF #Cric_Int_Care #ICU #clinicaltrials #fluidoverload

💦 Restricting IV fluids in adults with septic shock in #ICU : analysis of CLASSIC trial. Restriction resulted in similar survival, HRQoL, cognitive function at 1 year vs standard therapy but clinically important differences could not be ruled out
#FOAMcc
🖇️rdcu.be/deP7j

#CCR23

The #HOTCOVID trial on lower vs. higher oxygenation targets in ICU patients with #COVID19 has been terminated at 727-of-780 pts because of very slow enrolment. There has been very few #COVID19 pts in 🇩🇰🇨🇭ICUs this winter⬇️
cric.nu

Welcome to the ICU in Reykjavik to the GODIF trial. We are looking forward to the collaboration Martin Sigurdsson #CRIC_Int_Care #GODIF #ICU #clinicaltrials

Join us in Copenhagen 10-12 May 2023 for
the Scandinavian Intensivist Meeting
⭐️ Theme Better Life-Support
⭐️ Focus on data and discussion
⭐️ Engage w ICU doctor & nurse colleagues
⭐️ 200 Euro -the cheapest ICU meeting around?
⭐️ Incl full social program
scandinavianintensivistmeeting.nu

Discussing organic delirium at Psychiatric Center Glostrup today. CRIC

The second trial to be presented at #CCR23 is AID-ICU

Can haloperidol improve outcomes for patients with delirium?

Nina A-Ranberg presenting

Join us in Titanic Belfast, June 14th to 16th, to discuss the best critical care trials in the world.

criticalcarereviews.com/meetings/ccr23

#CLASSIC trial being discussed thoroughly by Mervyn Singer, Critical Care Reviews Morten Bestle Tine Sylvest Meyhoff at the Danish Intensive care meeting at beautiful Hindsgavl Castle

Very important data adding to those of the #CLASSICTRIAL

While awaiting long term follow up, Bayesian analysis of CLASSIC and updated meta-analysis, fluid restriction appears safe in patients with sepsis