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HOT-COVID trial results in a thread

The conclusion of #HOT_COVID_trial was
In adult ICU patients with COVID-19 and severe hypoxemia, targeting a Pao2 of 60 mm Hg (8 kPa) resulted in more days alive without life support in 90 days than targeting a Pao2 of 90 mm Hg (12 kPa)

Not that we hope to see COVID pts in ICU

Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19. The HOT-COVID Randomized Clinical Trial

Presented this morning at #isicem24 , published in JAMA

CCR Journal Watch
criticalcarereviews.com/latest-evidenc…

Get the latest critical care literature every…

Mark Peters Oxy-PICU Paediatric Critical Care Society ESPNIC PALISI ICNARC Thanks Mark, it's the work of many
Bodil S. Rasmussen Aalborg Universitetshospital
@JonLaake
Oslounivsykehus
Theis Lange
UCPH Healthscience
and 11 ICUs in CRIC
🇩🇰🇧🇻🇨🇭🇮🇸🏴󠁧󠁢󠁷󠁬󠁳󠁿
Funded DK Frie Forsk.fond

Vi søger en #projektkoordinator til INCEPT platformsforsøget
Del gerne og søg, hvis du vil være med til at forbedre behandlingen på ITA og generisk
Rigshospitalet

Sundhedsjobs.dk - Projektkoordinator til INCEPT Intensive Care Platform Trial sundhedsjobs.dk/jobopslag/4600…

The second version of the GODIF trial was adopted based on the lessons and is now enrolling in 23 ICUs in 🇩🇰🇫🇮🇧🇻🇨🇭🇳🇱 - 430 of 1000 patients enrolled
More certain evidence on the way for fluid overload ICU patients
pubmed.ncbi.nlm.nih.gov/37691474/

The first GODIF trial was terminated when only 41 patients had been enrolled because of difficulties in defining fluid status in clinical practice
Heaps learned - data reported as planned
pubmed.ncbi.nlm.nih.gov/36636797/

The systematic review identified 4 RCTs of 359 patients allocated to loop diuretics vs placebo
Analyses of mortality and SAE favoured diuretics, but fare too pts were enrolled
None had data on HRQoL
pubmed.ncbi.nlm.nih.gov/35696008/

⚠️Abstract deadline extension!

If you need more time to submit your original abstract for #EuroMed , today is your lucky day!

🔹The deadline has been extended to 09 February, 23:59 CET.

Don't wait any longer! Submit your work now! 👇loom.ly/0pD3nKQ

Haloperidol is by far the best studied antipsychotic in ICU pts with delirium
If clinicians consider using a drug, my suggestion is haloperidol as used in the #AIDICU trial
All RCTs pooled in this SR-MA
ccforum.biomedcentral.com/articles/10.11…

Should be worthwhile

Important work to inform clinical guidelines on #delirium in #ICU

CRIC
Nina A-Ranberg
Ole Mathiesen
Lone Musaeus Poulsen
Sjællands Universitetshospital
Rigshospitalet
Innovationsfonden

Worthwhile

Extremely important results showing us that many more trials should be done in pediatric ICU patients

#MethodMonday 43: Directed acyclic graphs (DAGs)
doi.org/10.1001/jama.2…

This week's paper is a brief introduction to DAGs. DAGs are used as a tool to specify analytical models in e.g. observational studies and a formalised approach to variable selection.. 1/..

A 🇩🇰 research hero simon vistisen
had to fight Edwards Lifesciences for his integrity and for the truth about the problems with a hyped #AI algorithm used during anesthesia
Lægemiddelstyrelsen EMAInfoCentre should react to ensure patient safety and reduce potential waste
health.medarbejdere.au.dk/en/display/art…

'Most people have no idea what they owe to this remarkable doctor and his colleagues in Copenhagen'

The doctor being the late professor in anesthesia Bjørn Ibsen

The Autumn Ghost—The Danish Polio Epidemic of 1952 and the Birth of Intensive Care Medicine jamanetwork.com/journals/jama/…