Absolutely thrilled to share this incredible work led by Jayoung Ryu ! A huge shoutout to the collaborative efforts with Sherwood Lab, Chris Cassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint! #CRISPR #BEAN 🧬🌟☕️

Very excited to see our work published in Nature Medicine today!

A unique autoantibody signature found in some patients w MS - 5 years before onset.

& the target of that autoimmune response bears remarkable similarity to many pathogens - including EBV.

nature.com/articles/s4159…

A really groundbreaking study that has the potential to identify patients at risk for developing MS years in advance. Congrats to Colin Zamecnik, PhD Gavin Sowa, Michael Wilson and team!

nature.com/articles/s4159…

Join us next week for a conversation with Dr. Caleb Lareau from Memorial Sloan Kettering Cancer Center!

His lab specializes in computational and translational immunology. Check out their @BiorxivPreprint on #scRNAseq to study rare cell states: bit.ly/3Jl2DbX

finally finished the antibody ML primer post

if you are in the protein ML field, not in antibody ML, and would like to understand antibody ML bit more, you’re my ideal audience!

abhishaike.com/2024/04/15/a-p…

🧵 🧵 🧵

📢 Senior #postdocs with diverse backgrounds in the biomedical sciences who are on the faculty job market this year - apply to our annual SKI Academic Job Search Bootcamp & present your research at the Emerging Leaders Symposium!
Apply by 5/31: tinyurl.com/2024Emergingle…

Reminder that we're back at it again tonight with a talk from Jacob Ulirsch, PhD (Illumina AI) on gene variant ID + interpretation. So so excited to have cool genomics content in our lineup 🥰

Register for location or watch via Zoom (link inside) 👋 lu.ma/f5c90tdp

As my lab develops Seurat, I wanted to share some thoughts on the important Seurat and scanpy package selection preprint from Joseph Rich/Lior Pachter 🧵

Check out this awesome digest on PERFF-seq from Tsion Abay about our time developing it in the Ansu Satpathy lab!

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/

nature.com/articles/s4158…

How can cell atlases of human tissues support drug target discovery? In a joint effort between Teichlab @Sanofi and Ensocell we tested whether info on cell type specific expression from scRNA-seq is associated w targets of clinically successful drugs medrxiv.org/content/10.110…

New preprint alert! 🚨🚨

Droplet-based single-cell profiling of somatic epimutations enable high-res natural lineage tracing.

A super fun collaboration with Centre for Genomic Regulation (CRG), co-supervised with Lars Velten, and co-led by Michael Scherer and Indranil Singh!

biorxiv.org/content/10.110…

The covariance environment defines cellular niches for spatial inference go.nature.com/4auQI72

I'm a sucker for good memeing in a scientific talk! #singlecellgenomicsday

We’d like to celebrate the innovation of PERFF-seq by Tsion Abay Ronan Chaligne (He/Him) Ansu Satpathy & @caleblareau! Their work, which leverages the Chromium Flex assay, will pave the way for new studies of rare cells. 👏

Opening talk of #singlecellgenomicsday by Rahul Satija who organises the event which is open to all and live streaming now!

Disclosure: I'm friends with several of these authors, and work at 10x Genomics, but I haven't been this excited about a new method for a long time. Really excited by all the possibilities that this method opens up

PERFFect day indeed 🤩 So excited to see this work that started during my deeply cherished time Ansu Satpathy ‘s lab & went on to become a multi-institution collaboration! Incredibly grateful to have been a part of this effort with thoughtful mentors Caleb Lareau & Bob Stickels!!