After more than a decade focused on genome editing of DNA, it could turn out that editing the #epigenome , which regulates gene expression, is a better, or, at the very least, a highly complementary strategy
nature.com/articles/s4158… Nature Genetics Cristina Policarpi Jamie Hackett EMBL…

Nearly five years and many a sleepless night later, it’s a pleasure to share my postdoctoral work exploring brain-skin circadian communication! So what did we do, what did we discover and what conclusions can we draw? 🧵1/17
cell.com/cell-stem-cell…
Aznar-Benitah Lab Cell Stem Cell

Tartan themed night ⁦ESTRO⁩ #ESTRO24 #presidentialdinner
⁦Fiona McDonald⁩ ⁦Gerry Hanna⁩ ⁦Marianne Aznar⁩ ⁦Anna Kirby⁩ @

FrezzaLab Alejo Rodriguez-Fraticelli, PhD Direna Alonso-Curbelo Nuria Lopez-Bigas Charles Swanton Love Mina Bissel’s take on this : ncbi.nlm.nih.gov/pmc/articles/P…

Our work shows the number of mutation-bearing lesions in the human pancreas is ~1000. The lifetime probability to develop pancreatic cancer: 1/60.

So, the probability for a single lesion to become cancer is minuscule: about 1/600,000.
(all approximate)

nature.com/articles/s4158…

Brilliant 2nd keynote to round off Science and Innovation at Cancer Research UK Scotland #PancreaticCancer symposium - Laura Wood Johns Hopkins Pathology demonstrating the power of machine learning model 'CODA' to enable 3D modelling of PanINs. Incredible spatial resolution (unlike this photo)...

🎥Get an exclusive sneak peak of our new Manchester Institute CRUK Manchester Institute! Partnering with The Christie NHS & The University of Manchester, we come back with the state-of-the-art £150m research centre to advance cancer diagnosis and treatment.

Check out the video tour here: news.cancerresearchuk.org/2024/05/03/vid…

Amazing- human pancreas 80cm3…. That’s a lot of kras mutations - yet lifetime risk of pancreas cancer is 1:60 - cancer is very rare at the cellular level
“mean burden of 13 PanINs per cm3; normal.. adult panc has 100s of PanINs, w oncogenic KRASm.”
nature.com/articles/s4158…

Researchers have observed a male orangutan treat a wound on his face with a plant that’s also used in human medicine.

It’s the first time any wild animal has been seen caring for a wound using a natural substance with known medicinal properties.

sciencenews.org/article/orangu…

A week of discoveries about our internal axes!
—Gut to sperm
nature.com/articles/s4158…
—Body to brain
nature.com/articles/s4158…
—Brain to muscle
science.org/doi/10.1126/sc…
—Brain to skin
sciencedirect.com/science/articl…

A big day for understanding the multi-dimensional impact of exercise that has such a critical impact for promoting health nature
nature.com/articles/s4158…
nature.com/articles/d4158…

Thank you to all at @UCLH and @MacmillanCancer for your tireless work to provide cancer patients with the best care and support. 

Marking His Majesty’s return to public duties, The King and Queen spent time with patients to hear about their ongoing treatment and support.

Monkeys in Bali have learnt that they can steal people's phone and negotiate there return for food

I am deeply disappointed by today's news. This announcement deals a significant blow to the Biden Administration's cancer moonshot goal to end cancer as we know it by reducing tobacco use.

Bispecific T cell engager therapy for refractory rheumatoid arthritis Nature Medicine nature.com/articles/s4159…

Eagles performing their classic 'Hotel California' on acoustic in 1994.

Probably one of the best versions of this song.
#Eagles

Amazing to see UCL Faculty of Medical Sciences ranked 1st for medical research in Europe and 3rd in the world 👏🏼👏🏼
Lungs for Living

Come and discover how new work could prevent tumour initiation and open up a new field of molecular cancer prevention.

🎙️ Other speakers at the #MedicineAtTheCrick event will include Direna Alonso-Curbelo, Simona Parrinello, ilaria Malanchi and Will Hill.

Join our next #MedicineAtTheCrick event, where researchers and clinicians will explore inflammation and cancer promotion.

Hosted by our Deputy Clinical Director and Science and Innovation at Cancer Research UK Chief Clinician Charles Swanton

📅 6 June 2024
🎟️ Free registration ⬇️

crick.ac.uk/whats-on/medic…