New hifiasm with the ultra-long integration is released! We tested it with four diploid human samples and got many T2T chromosomes. Any feedback will be much-appreciated Heng Li. Source code: github.com/chhylp123/hifi…

Today is the big day! The #T2T consortium is claiming victory and announcing that we have finally uncovered every last bit of the human genome! The papers are out today 🥳🧬 science.org/toc/science/37…

The previous hifiasm paper described haplotype-resolved assembly with trio data. In this new paper, Haoyu Cheng achieves chromosome-long phased assembly without parents. Tested for human and non-human species. A single executable and one command line for the entire process.

Latest from Haoyu Cheng, Heng Li and collaborators:
Haplotype-resolved genome assemblies produced by the new #hifiasm algorithm could accurately reveal complex genetic variations in #cancer genomes. Further development may lead to high-quality cancer #genome assemblies.

Yet another genome assembler, this time it is written in Rust.

Peregrine-2021: A faster and minimum genome assembler for long-reads with good enough accuracy

github.com/cschin/peregri…

#genomics #bioinformatics #rustlang

Hifiasm published in Nature Methods.

Preprint: arxiv.org/abs/2008.01237
Source code: github.com/chhylp123/hifi…
Assemblies: zenodo.org/record/4393631 & zenodo.org/record/4393750
Journal paper: nature.com/articles/s4159…

Fine work by Haoyu Cheng gconcepcion.bsky.social Xiaowen Feng Haowen Zhang

SR: This week Oxford Nanopore has generated modal *raw-read accuracy* of 99.1% (99%=Q20) using a new chemistry with Bonito, delivered on internal validation sets with a substantial fraction of these raw reads above Q20 #nanoporeconf

The Telomere-to-Telomere consortium is proud to announce our v1.0 release of a complete human genome. When Karen Miga asked me to team up on this a few years ago, I wasn't sure it would be possible. Now down to just 5 gaps. What a journey! Read more here genomeinformatics.github.io/CHM13v1/

Hifiasm, a haplotype-aware #HiFiReads assembler with builtin haplotig purging & much improved trio binning. Applied to human, mouse, maize, frog, octoploid strawberry & ~30Gb hexaploid redwood. By Haoyu Cheng, gconcepcion.bsky.social, Xiaowen Feng & Haowen Zhang at arxiv.org/abs/2008.01237