In this issue of Haematologica, a new study identified a novel potential therapeutic target for B-ALL: the mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1).
doi.org/10.3324/haemat…

May 2024 issue is available online. See and download for free the Haematologica Digital Edition! haematologica.org/preview/digita…

The appearance of #TP53_mutation in #myelodysplastic_syndrome with #del (5q) with #lenalidomide treated with #lenalidomide is a well-known event, but what happens after salvage with decitabine? The case of a 75-year-old man with #MDS del(5q). haematologica.org/article/view/h…

The risk of overtreating myeloma patients.
Read here the long story of the patient who lived for 20 years after a strategy of #minimal_myeloma_treatment .
haematologica.org/article/view/h…

Can we switch on a natural killer against #acute_myeloid_leukemia ( #AML )?
There is no effective immunotherapy for AML. However, a new study takes a step towards identifying a potential immuno-target in AML.
haematologica.org/article/view/h…

Here, Cournoyer and colleagues describe their experience with the #BRAF -inhibitor dabrafenib and the #MEK -inhibitor trametinib to treat patients with newly diagnosed or relapsed/refractory #Langerhans_cell_histiocytosis . haematologica.org/article/view/h…

What is the role of the transcription factor #MYC for clinical outcome in #mantle_cell_lymphoma ( #MCL )? The new study by Rodriguez and colleagues gives the answer. haematologica.org/article/view/h…

Machine learning methods: a new study examining validation of the European LeukemiaNet 2022 criteria and genomic clusters in older adults with #acute_myeloid_leukemia . haematologica.org/article/view/h…

Read here the updated efficacy and safety analyses from the LOTIS-2 trial studying #Loncastuximab_tesirine (Lonca) as single agent in heavily pre-treated patients with relapsed/refractory diffuse large #B -cell_lymphoma. haematologica.org/article/view/h…

Are eligibility criteria of clinical trials ethical?
A new study analyzes the use, variability, and drug safety-based justification of eligibility criteria in #acute_leukemia trials. haematologica.org/article/view/h…

A new review explores the physiology and physiopathology of #D -dimer formation and summarizes the main conditions associated with increased D-dimer while proposing a new approach to their management.
haematologica.org/article/view/h…

#LandmarkPaper : “Every single patient can teach us important lessons”. What the very first two cases of children with acute lymphoblastic leukemia treated with
#CAR_ T_cells taught us.
haematologica.org/article/view/1…

April 2024 issue is available online. See and download for free the Haematologica Digital Edition! haematologica.org/preview/digita…

Clinicians can personalize their approach and select the most appropriate histone deacetylase inhibitor to enhance or maintain #CCR4 expression in adult #T -cell #leukemia /lymphomaCells
haematologica.org/article/view/h…

Are there differences in survival and disparities in treatment between children and adolescents and young adults (AYA) with #non -HodgkinLymphoma ( #NHL )?
haematologica.org/article/view/h…

#LeukemiaStemCells ( #LSC ) are responsible for the initiation, development, and relapse of #acuteMyeloidLeukemia ( #AML ). #DNAJC10 , an #ER #co -chaperone, emerged as an independent predictor of survival in AML.
haematologica.org/article/view/h…

Children with #acuteMyeloidLeukemia ( #AML ) with t(7;12)(q36;p13), leading to an #MNX1 ::ETV6 fusion, have a poor outcome. The identification of the transforming event in this AML leads to possible new ways to treat it. haematologica.org/article/view/h…

A new study on the characterization of the B-cell receptor of monoclonal B lymphocytosis in siblings of patients with #chronicLymphocyticLeukemia ( #CLL ) provides insights into the early steps of the development of CLL. haematologica.org/article/view/h…

#Eculizumab and #ravulizumab , first-line treatments of #PNH ), inhibit the activity of complement component 5 (C5). haematologica.org/article/view/h…

Read here a new study examining the role of #genomicBreakpoint -specificMonitoring of #minimal /measurableResidualDisease ( #MRD ) in pediatric non-standard-risk #acuteMyeloidLeukemia .
haematologica.org/article/view/h…