Excited to finally see this work come out online Nature Portfolio. In this work we identify FOXO1 overexpression as a strategy to improve CAR T cell persistence and metabolic function using CAR T derived from mice, healthy donors and cancer patients.

nature.com/articles/s4158…

Why human anti-CTLA-4 antibodies do not deplete intratumoral Tregs ?

We show that FcyRIIB acts as a checkpoint restricting the Fc-dependent activity of human anti-CTLA-4 and other Treg-targeting antibodies in tumor.

Rockefeller University Cancer Immunology Research

aacrjournals.org/cancerimmunolr… (1/10)

Thanks for having me ICGEB !- It was wonderful to meet all your faculty and amazing students. I hope I'm back again very soon!

Congratulations to our colleagues at ICGEB Official and the Emory Vaccine Center for this new work Nature Medicine finding pre-existing immunity to dengue does not increase risk of severe disease on subsequent infections!
rdcu.be/dxWxc
Thread below!

If you are exploring #cancerresearch #postdoc opportunities in the southeast, please apply to a special 2 day in person postdoctoral recruiting event at @Winship this March. Meet us and join our wonderful oncology research community!

Thanks for having me NYU Langone Health! Very much enjoyed meeting all your excellent immunologists!

Please reach out to learn more about our new and growing program!
⭐️ incredible clinical volume and complexity
⭐️ unique clinical trials infrastructure
⭐️ world class translational science opportunities
⭐️ Atlanta is awesome

Thanks for having me! What an amazing group of cancer immunologists all in one place. Truly a special thing.

What a fantastic paper - this will be in every Immunology class I give for a long time.

Thrilled to share the first research story from my lab ONJ Cancer Research Institute published in Science Immunology. A real team effort from all lab members, in particular Marina Yakou Gh_So Kelly Tran & Dinesh Raghu

science.org/doi/10.1126/sc…

T cell responses matter during 'breakthrough' SARS-CoV-2 infection. Here's new work from Mark Painter Really supports the notion that we should be trying to measure T cells as a correlate of protective immunity for SARS-CoV-2 (and maybe other) vaccines. nature.com/articles/s4159…

Excited to announce that this manuscript is officially out in the latest issue of JCI! Thanks again to all the coauthors and of course to my postdoc mentor Don Gibbons for his continual support! The model figure from these studies:

Happy to share that our story is out! Science Immunology
Our study demonstrates that sustained CD28 signaling, is required to maintain PD-1+ CD8 T cells during chronic antigen stimulation (1/)
science.org/doi/10.1126/sc…

🪩New pub out 🪩 My first first-author pub released Science Translational Medicine just in time for my 30th bday! 🎂 FcgRIIB on CD8 T cells (yes T cells!) may be a mechanism of resistance to cancer immune checkpoint therapy. A thread summarizing our main findings: We show…

science.org/doi/10.1126/sc…

Hi #medtwitter ! I'm Carey Jansen and I'm applying #internalmedicine with an interest in research track programs and medical #oncology . My scientific interests are in mechanisms of immune organization in cancer and the response to #immunotherapy .
#Match2024

1) In 1979, Tew and Mandel published a visionary answer to a longstanding question:

How long is antigen retained in the draining lymph node after immunization?

🧵

Short answer: quite a while
bit.ly/TewMandel1979

Meet Carey Jansen, PhD, #Treasurer of the APSA this year and an MD/PhD Student Emory MSTP . Her PhD is focused on studying tumor #immunology in genitourinary cancers in the Haydn Kissick Lab. Carey Jansen is passionate about seeking innovative answers to translational research questions

So excited for our new publication in Nature Communications demonstrating a novel membrane-bound IL-12 engineered regionally-delivered CAR T cell approach to target multi-metastatic solid tumors. Congrats to @heejunlee920505, John P. Murad and #pricemanlab #coh nature.com/articles/s4146…

Something for everyone! Published today in Nature Immunology 🎉 Our latest collab with Gavin Painter, Ian Hermans & others, packed with mRNA vaccines, TRM, liver immunity and preventing malaria.
Doherty Institute UniMelb MDHS Malaghan Institute Ferrier Research Institute
🧵 👇
nature.com/articles/s4159…

Awesome work Chaoran Li! Really interesting that Treg function is specifically regulated by the metabolic environment.