New news! Our latest (preprintless) story on MVB maturation taking place on a subset of septin-coated microtubules. Ben Robinson's PhD thesis and the last opus from my 15-year Drexel residency. A tweetorial to follow.

Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule -associated #septins , which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from Elias Spiliotis Drexel University College of Arts and Sciences UVa Cell Biology: hubs.la/Q02v9FQ30

Viewpoint: Campanella and Kannan Queen Mary University of London discuss the emerging knowledge of the molecular composition and function of mitochondrial–nuclear contact sites in eukaryotes, including recent work by Jana @sheinerlab et al. (hubs.la/Q02v9q590): hubs.la/Q02v9mBl0

Ward, Vangala, Kamber Kaya, Radhakrishnan et al VCU show that in addition to its role as a positive regulator of #proteasome genes, the transcription factor Nrf1/NFE2L1 can also induce #autophagy –lysosomal pathway genes & drive autophagic flux hubs.la/Q02tZ1CK0

Wang, Lu et al. Cincinnati Children's demonstrate the critical role of BRG1/SMARCA4 for #oligodendrocyte precursor cell differentiation and remyelination hubs.la/Q02tPfbS0

We are extremely happy to see our work
published in JCellBiol where we show how #UBAP2L promotes assembly and stability of nuclear pore complexes #NPCs during interphase. Thank you to Yongrong LIAO and all authors and reviewers for an amazing job! 🙏🥳🤩

rupress.org/jcb/article/22…

.Yongrong LIAO et al. Izabela Sumara IGBMC show how UBAP2L facilitates assembly and stability of mature NPCs at the nuclear envelope during early interphase to ensure efficient nuclear transport, adaptation to nutrient stress, & cellular proliferative capacity hubs.la/Q02tP01h0

Spotlight: Antonio Galindo MRC Laboratory of Molecular Biology highlights new results from Assaad, Wiese, and colleagues (hubs.la/Q02tNDbj0) showing how the TRAPPII complex orchestrates growth decisions when resources are limiting. hubs.la/Q02tNCmS0
#PlantBiology #Trafficking

Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic #StemCells . A new study from Yung-Li Chen, Andreas Ettinger, Maria-Elena Torres-Padilla (ME Torres-Padilla) et al Helmholtz Munich | @HelmholtzMunich: hubs.la/Q02t0S800

#CellDivision #centromeres

OMA1 clears traffic jam in TOM tunnel in mammals. Shiori Sekine and Yusuke Sekine Aging Institute - University of Pittsburgh/UPMC discuss the work by Krakowczyk et al. (hubs.la/Q02sSPX90) in Spotlight ➡️ hubs.la/Q02sSKgC0

#Organelles #mitochondria

Yiyang Han and Li Yu Tsinghua University reveal how calcium regulates migrasome formation and propose a sequential interaction model involving Syt1 and Tetraspanins in the formation and stabilization of #migrasomes . hubs.la/Q02tCcjV0

#migration #motility #membrane #lipid

Model of Caspase-1 mediated HFSC homing to the epidermis upon wounding. From Hegde, Ghosh et al. Skin homeostasis & inflammation lab DBT-inStem uncovering that extracellular Caspase-1 induces hair stem cell #migration in wounded and inflamed skin conditions hubs.la/Q02s94ry0

#StemCells

Behind every thorough #PeerReview is a collaborative effort. Rockefeller U. Press journals encourage co-reviewing manuscripts w/ trainees ( #gradstudents & #postdocs ) and recognize the invaluable contributions of co-reviewers. Learn more about our initiative: hubs.la/Q02qzgHy0

Image shows fragile X–related (FXR) family proteins promote viral replication. From Li et al. showing that liquid–liquid phase separation of FXR proteins drives clustering of replication organelles of #SARSCoV2 . hubs.la/Q02s92vk0

#COVID19 #Virology #Organelles

Image: other proteins implicated in IRE1α activation have structural motifs similar to A1 segment of cholera toxin (CTxA1). Simpson et al. Boston Children's show that IRE1α recognizes a structural motif in CTx to activate an unfolded protein response hubs.la/Q02rZvm_0

Image shows multiplex staining of phosphoinositides across scales, using recombinant biosensors for the multiplex and super-resolution detection of phosphoinositides, developed by Hannes Maib Francesca Bottanelli, Petia Adarska, David Strutt and colleagues: hubs.la/Q02rZvyd0

Robinson et al. Cambridge University investigate the role of the AP-1 adaptor complex in outgoing and incoming membrane traffic. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes. hubs.la/Q02rZfx_0

Image shows BUB-3 recognition of pMELT motifs drives the rapid increase in BUB-1–BUB-3 localization at kinetochores during mitotic entry. From Houston, Kim, Arshad Desai Oegema/Desai Labs and colleagues: hubs.la/Q02rZdtJ0

#CellCycle #CellDivision #Genetics #Biochemistry

Physiological Faa1 membrane localization is required for efficient #lipid incorporation and maintenance of autophagic flux. From Baumann, Achleitner, susanna.tulli, Sascha Martens et al. dissecting Faa1 function and recruitment during #autophagy hubs.la/Q02rQDVY0

At Rockefeller U. Press, we value the collaborative efforts behind #PeerReview . So we implemented a process allowing invited reviewers to formally acknowledge their co-reviewers’ efforts. Take advantage of our Co-Reviewer Recognition initiative: hubs.la/Q02qzgK50