Hey #BIN23 ! Checking in for #BlackInNeuroRollCall . My name is Kanisa. I am 5th year Behavioral Neuroscience doctoral candidate at UAB. I study the proteasome’s role in learning and memory using electrophysiology. Can’t wait to connect with you all!

The elusive goth jock...

Fantastic Moffitt Cancer Center double act from Conor Lynch & @dbasanta presenting, The Role of the Bone Microenvironment in Multiple Myeloma Relapse and the Emergence of Resistance to Proteasome Inhibitors #CSBCPSON23 IMO

What actually happen in the proteasome when you add MG132.

Don't miss the TPD seminar on 4/27 at 12 pm EDT featuring Dr. Erin Dueber Genentech, who will present on 'Targeted Degradation via Direct 26S Proteasome Recruitment.'

Please be aware that this seminar won't be recorded, so join us live!

🔥super excited to share that I have just been awarded with a grant from DFG public | @[email protected] to study the genetics of autism spectrum and protein degradation machineries in the developing cortex! 🤩 ubiquitin and proteasome to the front! 🥽🥼🔬🧫

A protein entering the proteasome

🔬 Unlocking the genetic mysteries of Dubin-Johnson syndrome! The paper reveals how the ABCC2 p.R393W variant plays a crucial role, targeting MRP2 to proteasome degradation.

Discover more via 🖇️ egastroenterology.bmj.com/content/2/1/e1…
#DubinJohnsonSyndrome #Genetics #Research #Science

We show that leaf cell expansion is affected by chloroplast-generated redox signals through the modulation of proteasome activity and endoreduplication.

Through a combination of cell biology, biochemistry and time-resolved #proteomics during leaf development, we were able to uncover the involvement of proteasome activity and endoreduplication in this phenotype.

🚨Excited to share that our manuscript is now published in NatureStructMolBiol. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone -mediated multistep assembly pathway of the human 20S #proteasome .

Max Planck Institute of Biochemistry (MPIB) Harvard Med Cell Bio Aligning Science Across Parkinson’s

nature.com/articles/s4159…

I love electron microscopy. Look at them all lined up, ready to be imaged [20S proteasome 2D crystal. source: ncbi.nlm.nih.gov/pmc/articles/P…].

This clown.

Join us next week for #DegradoZoom on July 6th, 12pm EST:
Bernat Crosas Bernat Crosas IBMB: Development of proteolytic chimeras based on direct 26S proteasome targeting
Muhar Matthias Matthias Muhar ETH Zürich: A chemical degron marks C-terminally modified proteins for degradation

Proteasome inhibitors increase risk of HF, Gr 3 ischemic heart disease,arrhythmias & AF
MOA: impairment of activation of NF-κB which affects angiogenesis & survival of cardiac myocytes, w protein accumulation & mitochondrial dysfunction affecting contractility #mmsm #USMIRC

Join us for our last DegradoZoom of 2023, featuring University of Bonn's Radek Nowak Radek Nowak on 'Structure-based Design of Covalent Cereblon Binders' and Christian Steinebach Christian Steinebach on 'Targeting the Ubiquitin-Proteasome-System with PROTACs.' Thursday, Dec 14th, 11am EST

The bacterial effector SAP05 bypasses the Ub-dependent pathway for protein degradation. Its bimodular design uniquely interacts with the proteasome, leading to direct targeted degradation in eukaryotic cells. Potential for new TPD technologies unveiled! pnas.org/doi/epdf/10.10…

🎯Comprehensive Review

Development of Proteasome Inhibitors for Cancer Therapy

Scilight Science #MedEd #MedX #pharmaceutical #Pharmacology #Science #review #oncology #CancerResearch #Proteasome

sciltp.com/journals/ijddp…

#Myeloma Paper of the Day: Study of outcomes in patients receiving salvage after BCMA-specific CAR-T on LEGEND-2 finds median PFS was 16.3 months w/ better outcomes if had proteasome inhibitor-based combination but worse with extramedullary disease: pubmed.ncbi.nlm.nih.gov/38369805/.

Cellular Trash Compactors

Our cells have nano-sized machines that are responsible for disposing of proteins in our cells that are targeted for destruction. This protein trash compactor is called a proteasome (image below).

As proteins in our cell age, they become damaged due…