Bedtime reading 😀 #WeTheFibrosisLab 🔬 #STARConsortium . Stay tuned for more news coming soon… Pranab Mukherjee Jyotsna Chandra, Ph.D. Ren Mao，MD，PhD Idan Goren Miguel Regueiro Stefan Holubar MD MS Katie Falloon Suha Abushamma, MD Joseph Sleiman, MD Taha Qazi David Bruining Sara El Ouali MD Arielle Kanters

In the latest issue! Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling dlvr.it/T5SptP

Wishing the staff at Cleveland Clinic a happy #DoctorsDay .
Our team includes nearly 6,000 staff in 4 countries, 23 hospitals and 270 outpatient sites.
Your sacrifice and dedication make it possible to deliver exceptional care to every patient. We thank you today and every day.

👉🏽NEW publication from ⁦Jie Wang⁩ #WeTheFibrosisLab 🔬 #STARConsortium 👈🏼 Preventing fibrosis in IBD: update on immune pathways and clinical strategies: Expert Review of Clinical Immunology ⁦Miguel Regueiro⁩ ⁦Pranab Mukherjee⁩ ⁦ tandfonline.com/doi/full/10.10…

Gut fungi may contribute to the underlying mechanisms of IBS.

But are we ready to use yeast probiotics for IBS?

gutmicrobiotaforhealth.com/yeast-probioti…

February covers from #CellPress . Which is your favorite?🐉

Happy International Women's Day!

We're celebrating women who have changed the world. Here's all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award.

Who are the women who inspire you the most?

#IWD2024

☀️☀️New paper from Cathy Lu (Prof. Cathy Lu) who is building an IUS index for Crohn‘s disease strictures in #STARConsortium 🌟🌟 Credit to her strong, humble and effective leadership #WeTheFibrosisLab 🔬Miguel Regueiro David Bruining Vipul Jairath MBChB DPhil Anja Poulsen Christina Ha MD Meena Bewtra

Today, Cleveland Clinic was recognized as the No. 2 hospital in the world by Newsweek.

This is a reflection of the dedication and compassion of our 81,000 caregivers worldwide who are committed to our patients and our communities.

Read more: cle.clinic/4bXw4h2

Inspirational visit by William Faubion (Prof. Bill Faubion) Cleveland Clinic Lerner Research Institute Cleveland Clinic. A role model for physician scientists and amazing data on epigenetics in #IBD . Thank you for coming. Manuel Braga Neto MD, PhD Christina Ha MD American Gastroenterological Association (AGA) Gui Ramos MD Miguel Regueiro

More than 48,600 18-year-olds are registered to vote in Ohio, a 35% increase from late August on.wews.com/3IhyZU8

Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD Crohn's & Colitis Foundation Helmsley Charitable Trust Daniel Worthley Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM David T. Rubin, MD Extracellular Matrix News Edward Loftus Y-ECCO The Extracellular Matrix Pharmacology Congress Michael Elias, PhD Sara Horst MD, MPH, FACG Fernando Gomollón Remo Panaccione, MD, FRCPC Dr Mark Silverberg Healio Gastroenterology @IBDConference Peter Higgins Stefan Holubar MD MS Ruben Hernaez IBD Nurse Kay Tauseef Ali MD, FACG AGAF FACP Joseph Sleiman, MD Kira Newman, MD, PhD Maria T. Abreu Bincy Abraham, MD, MS Dr Dermot McGovern Caro Park Vipul Jairath MBChB DPhil Jean-Frederic Colombel Taku Kobayashi Miguel Regueiro Suzanne Devkota GutlessandGlamorous Grateful to Sinan Lin MD Jie Wang #WeTheFibrosisLab Pranab Mukherjee Jyotsna Chandra, Ph.D. Idan Goren Manuel Braga Neto MD, PhD #WeTheFibrosisLab ☀️ We are focused on discovery of anti-fibrotic drugs and enabling trials in stricturing Crohn’s disease ☀️ 🧵(8/8) Thread end. Thank you for joining.

Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD Crohn's & Colitis Foundation Helmsley Charitable Trust Daniel Worthley Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM David T. Rubin, MD Extracellular Matrix News Edward Loftus Y-ECCO The Extracellular Matrix Pharmacology Congress Michael Elias, PhD Sara Horst MD, MPH, FACG Fernando Gomollón Remo Panaccione, MD, FRCPC Dr Mark Silverberg Healio Gastroenterology @IBDConference Peter Higgins Stefan Holubar MD MS Ruben Hernaez IBD Nurse Kay Tauseef Ali MD, FACG AGAF FACP Joseph Sleiman, MD Kira Newman, MD, PhD Maria T. Abreu Bincy Abraham, MD, MS Dr Dermot McGovern Caro Park Vipul Jairath MBChB DPhil Jean-Frederic Colombel Taku Kobayashi We feel this is important as we provide a functional link between the Crohn’s disease stricture matrisome and fibrogenesis Miguel Regueiro Joseph Sleiman, MD Fernando Gomollón Suzanne Devkota GutlessandGlamorous Aline Charabaty, MD, FACG, AGAF Cathy Lu Michael Todd Dolinger, MD MBA Stefan Holubar MD MS 🧵(7/8)👇🏽

Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD Crohn's & Colitis Foundation Helmsley Charitable Trust Daniel Worthley Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM David T. Rubin, MD Extracellular Matrix News Edward Loftus Y-ECCO The Extracellular Matrix Pharmacology Congress Michael Elias, PhD Sara Horst MD, MPH, FACG Fernando Gomollón Remo Panaccione, MD, FRCPC Dr Mark Silverberg Healio Gastroenterology @IBDConference Peter Higgins Stefan Holubar MD MS Ruben Hernaez IBD Nurse Kay Tauseef Ali MD, FACG AGAF FACP Joseph Sleiman, MD Kira Newman, MD, PhD Maria T. Abreu Bincy Abraham, MD, MS Dr Dermot McGovern Caro Park Vipul Jairath MBChB DPhil Jean-Frederic Colombel Taku Kobayashi Inhibition of focal adhesion kinase blocks the response of intestinal myofibroblasts and experimental colitis to MFGE8 Tina Aswani-Omprakash, MPH Sara El Ouali MD Ronald Oriana M. Damas, MD Taha Qazi Rita Rys Kenneth Rainin Foundation Ashley Villani John Vargo 🧵(6/8)👇🏽

Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD Crohn's & Colitis Foundation Helmsley Charitable Trust Daniel Worthley Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM David T. Rubin, MD Extracellular Matrix News Edward Loftus Y-ECCO The Extracellular Matrix Pharmacology Congress Michael Elias, PhD Sara Horst MD, MPH, FACG Fernando Gomollón Remo Panaccione, MD, FRCPC Dr Mark Silverberg Healio Gastroenterology @IBDConference Peter Higgins Stefan Holubar MD MS Ruben Hernaez IBD Nurse Kay Tauseef Ali MD, FACG AGAF FACP Joseph Sleiman, MD Kira Newman, MD, PhD Maria T. Abreu Bincy Abraham, MD, MS Dr Dermot McGovern Caro Park Vipul Jairath MBChB DPhil Jean-Frederic Colombel Next generation sequencing and functional validation reveals integrin alpha v beta 5 as a putative binding partner for MFGE8 Taku Kobayashi Michelle Kim Dr Yoon-Kyo An Katie Falloon Dana Lukin MD, PhD Scott D Lee, MD @AllAboutB Cleveland Clinic Lerner Research Institute Nick Davidson Mesenchymal Cell News 🧵(5/8)👇🏽

Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD Crohn's & Colitis Foundation Helmsley Charitable Trust Daniel Worthley Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM David T. Rubin, MD Extracellular Matrix News Edward Loftus Y-ECCO The Extracellular Matrix Pharmacology Congress Michael Elias, PhD Sara Horst MD, MPH, FACG Fernando Gomollón Remo Panaccione, MD, FRCPC Dr Mark Silverberg Healio Gastroenterology @IBDConference Peter Higgins Stefan Holubar MD MS Ruben Hernaez IBD Nurse Kay Tauseef Ali MD, FACG AGAF FACP Joseph Sleiman, MD Kira Newman, MD, PhD MFGE8 reduces #ECM deposition by normal intestinal myofibroblasts but not by intestinal myofibroblasts derived from Crohn’s disease strictures Maria T. Abreu Bincy Abraham, MD, MS Dr Dermot McGovern Caro Park Vipul Jairath MBChB DPhil Jean-Frederic Colombel J Calvin Coffey Michael J Rosen, MD, MSCI Katie Dunleavy 🧵(4/8) 👇🏽

Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD Crohn's & Colitis Foundation Helmsley Charitable Trust Daniel Worthley Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM David T. Rubin, MD Extracellular Matrix News Edward Loftus MFGE8 ameliorates experimental murine fibrosis Y-ECCO The Extracellular Matrix Pharmacology Congress Michael Elias, PhD Sara Horst MD, MPH, FACG Richard M. Wardrop III, MD, PhD, FAAP, FACP, SFHM Fernando Gomollón Remo Panaccione, MD, FRCPC Dr Mark Silverberg Healio Gastroenterology @IBDConference Shomron Ben-Horin Peter Higgins Stefan Holubar MD MS Ruben Hernaez 🧵(3/8) 👇🏽

Matrisome analysis of Crohn’s disease strictures reveals upregulation of MFGE8 Axel Dignass Aline Charabaty, MD, FACG, AGAF Raja Atreya Anja Poulsen Suha Abushamma, MD Michel Adamina Shomron Ben-Horin Dominik Bettenworth Bram Verstockt Edward Barnes MD MPH Christina Ha MD 🧵 (2/8) 👇🏽

☀️☀️ Arrived today from #WeTheFibrosisLab #STARConsortium ☀️☀️ Thank you Gut Journal for highlighting our work ☀️☀️ Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis gut.bmj.com/content/early/… Check it out 👇🏽A thread 🧵 (1/8) Miguel Regueiro Joseph Sleiman, MD