JExpMed
@JExpMed
The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress
ID:75302402
http://www.jem.org 18-09-2009 15:08:42
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Lui, Hoenig et al. Elena Hsieh lab describe a human LCK variant causing partial loss-of-function incl. defective TCR signaling & T cell development. hubs.la/Q02sjj5M0
Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjxR20
Jain et al. Boston Children's discuss recent findings on how immune cells instruct the development and persistence of adaptive and maladaptive pain states by modifying neural activity in the end organs, nerves, dorsal root ganglia, spinal cord, and brain. hubs.la/Q02sHS7k0
First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant, from E. Bernaldo-de-Quirós, Correa-Rocha et al. LIR lab-Madrid #immunology: hubs.la/Q02sjjTk0
Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjxxk0
Lin, Chen et al. UCLA Chemical and Biomolecular Engineering Parker Institute for Cancer Immunotherapy show that CAR-T cells engineered to secrete cytokine modulators can reduce cytokine release syndrome-related toxicity while simultaneously improving in vivo antitumor efficacy. hubs.la/Q02sHzDm0
#TumorImmunology #Immunotherapy
ICYMI... check out the #JEM_Spotlight study picked by Montse Cols! twitter.com/12663822516061…
See #JEM_Spotlight for April to celebrate #HKS2024 , from Daniel Michelson, Diane Mathis and colleagues on Hnf4 activating mimetic-cell enhancers to recapitulate gut and liver development within the #thymus bit.ly/3ri9opa. Come and say hi 👋!
McElwee et al. show that the CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune #tolerance . hubs.la/Q02sjrXr0
Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjm3L0
ICYMI: we present a special magazine w/ some of the research articles from our Cancer Collection (hubs.la/Q02rQ2--0), as well as cancer research published in other Rockefeller U. Press journals, JCellBiol & LifeScienceAlliance. Download the PDF ▶️ hubs.la/Q02rQj-30
Inherited human ITK deficiency impairs IFN-γ immunity and underlies #tuberculosis . From Masato OGISHI, Stephanie_Boisson-Dupuis et al. Casanova Lab: hubs.la/Q02sjvnF0
Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjx0x0
Wu, Kyle Travaglini, Arjun Rustagi, BlishLab, Krasnow et al define cellular tropism & transcriptomic effects of #SARSCoV2 virus. Interstitial #macrophages are a dominant target of viral takeover, #inflammation , & destruction in #COVID19 initiation. hubs.la/Q02sqFTg0
Insights from Pires and Longman Weill Cornell Medicine IBD: Schmitt et al (hubs.la/Q02sqvkz0) identify TL1A as an epithelial alarmin constitutively expressed by a subset of lung epithelial cells, which is released in response to airborne microbial challenge hubs.la/Q02sqmcH0