Very excited to see our work on PRC1 and chromatin condensation online Molecular Cell cell.com/molecular-cell… I am grateful to have worked with and learned from Sharon and Theresa Oei during this project! Many thanks to Radhika and Bob for their guidance and support throughout!

TODAY: at 2:00 PM EDT, Aleksandar Radakovic (BBS) defends his dissertation 'Primordial role for RNA aminoacylation in the assembly of structured and functional chimeric RNAs'. To access Zoom: projects.iq.harvard.edu/dmsdefenses
BBS at Harvard

Marta Brandt and colleagues at Broad Institute Dept. of Molecular Biology, MGH Mass General Research Institute applied translational genetics to a rare CARD9 missense variant linked with dermatophytosis and uncovered a signaling switch that controls tissue immunity against fungal infection, now online in Cell Reports!

In a recent Molecular Cell publication, researchers from Dept. of Molecular Biology, MGH and colleagues discovered new insights into the silencing of X-chromosome genes passed from fathers to daughters.

Read more: massgeneral.org/news/press-rel… Jeannie Lee #genetics #chromosome

Continuing our study of the somatic segregation of pathogenic mitochondrial DNA variants. T cell activation selects against the m.3243A>G variant in a manner that persists with time/age. Vamsi Mootha Broad Institute MGH Neurology Dept. of Molecular Biology, MGH
pubmed.ncbi.nlm.nih.gov/38499449/

Leveraging our discovery of markers of mitochondrial disease, our collaborative team Mass General Brigham now reports plasma N-lactoyl amino acids and f-MET as markers of sepsis severity and mortality in the ICU. Metabolomics

rdcu.be/dBGcC

Imprinted X-chromosome inactivation through inherited silencing of the oldest genes -- Check it out here! And congrats to Chunyao Wei (with Hao Yin and Barry Kesner) for the outstanding work!
sciencedirect.com/science/articl…

Researchers from Dept. of Molecular Biology, MGH and colleagues investigate cellular pathogenesis in Friedrich's ataxia, in a Molecular Cell study. doi.org/10.1016/j.molc…

Meet #theNodeCorrespondents —Shreyasi Mukherjee

In this interview, Shreyasi Mukherjee, a postdoc Dept. of Molecular Biology, MGH Harvard Medical School, talks about her ideas for the Node, including writing about stem cell-based embryo models and highlighting scientists from the Global South:
thenode.biologists.com/meet-the-node-…

Researchers from Dept. of Molecular Biology, MGH and colleagues investigate hypoxia-driven rescue of mitochondrial disease, in a Cell study. doi.org/10.1016/j.cell…

Latest from the Hung group and colleagues:

Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis | mBio journals.asm.org/doi/10.1128/mb…

Hypoxia rescue (& hyperoxia sensitivity) of mito CI mutants is evolutionary conserved! Harnessing the power of worm genetics, Josh Meisel w/ ⁦⁦⁦Gary Ruvkun⁩ discovers “hypoxia mimetic” and “hypoxia resistant” mutants, yielding key mechanisms. cell.com/cell/fulltext/…

Delighted to share new study by Tslil Ast now Weizmann Institute w/ Y. Itoh, D. Suess, Alexey Amunts showing (1) the Fe-S proteome is destabilized w/frataxin loss, (2) mitoribosome assembly factor METTL17 harbors a 4Fe-4S cluster, serving as an Fe-S checkpoint for mito translation.

Excited to share our work where we utilized cryo-FIB-SEM and cryo-ET to uncover distinct trends in cristae architecture influenced by the balance between s-Opa1 and l-Opa1 and detail associations between mitochondrial ultrastructure and functions. embopress.org/doi/full/10.10…

How do baculoviruses protect their genome?

Delighted to present our findings in print!

We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.
❄️🔬

nature.com/articles/s4146…

First post, first preprint from my postdoc in the Kingston Lab: Tuning condensates - How Polycomb Repressive Complex 1 subunit combinations determine condensate initiation, morphology, stability, and dynamics biorxiv.org/content/10.110…

Excited to share our latest work determining biological functions of disease risk genes! science.org/doi/10.1126/sc…
Chenhao Li Toufic Mayassi Helen Lin Koushik Ghosh Alok Jaiswal
Mass General Research Institute Dept. of Molecular Biology, MGH Broad Institute

Excited to announce the opening of the Strecker lab at MGH Molecular Biology/CCIB and HMS Genetics. I am tremendously grateful to all of my labmates who have helped me over the years, my past mentors Daniel Durocher and Feng Zhang, and my new colleagues Dept. of Molecular Biology, MGH for the opportunity!

Congratulations to Sneha Rath on winning the 2023 #LaskerEssay Contest!
Read her winning essay, “Cementing the Bricks,” here: ow.ly/g5b150Peh4A
MassGeneral News Harvard Medical School Broad Institute

Groundbreaking news in #FragileX #research ! Dr. Lee's lab Jeannie Lee has uncovered two methods to reactivate the silenced FMR1 gene. FRAXA has been backing this promising work for seven years. #FXResearch .
fraxa.org/unraveling-fra…