#Cancer impacts every family and community, and it is time to #EndCancerAsWeKnowIt . My family and I have been overwhelmed by the support in the wake of this announcement whitehouse.gov/briefing-room/… – thank you! I was at a loss for words, but I decided to share a 🧵: 1/

Happy to present our latest paper in Cancer Immunology Research from Jess Roetman, PhD 🏳️‍🌈, the whole Philip Lab team and Drs. Youngmin Lee and Ting-Fang Less VUMC Surgical Sciences !

#OnlineFirst : Tumor-reactive CD8+ #Tcells enter a TCF1+PD1– dysfunctional state, by Jess Roetman, PhD 🏳️‍🌈, Mary Philip et al.
bit.ly/3MxT9w1
Minna Apostolova Vanderbilt School of Medicine

Congratulations to Jess Roetman, PhD 🏳️‍🌈, Megan Erwin , Michael Rudloff , Philip Lab, and everyone else involved on putting this story together! 🎉 A really interesting perspective on how antigen origin impacts T cells!

My first author publication out, alongside Xiaopeng is now out at Cancer Discovery! Read below for a short summary:

I’m so excited to share that my paper is now online at Cell Reports! We use optical imaging to examine the spatial organization of presynaptic calcium signals. More details below 🧵👇

cell.com/cell-reports/f…

So excited to see our paper out in Cell Genomics today!! Thanks to all of our collaborators and co-authors for their help and hard work! And special thanks to George Xu for the many hours and late night zoom meetings spent working on this project together!

Congrats to Brenna Appleton and Amy Major! Oxidized lipids make Treg pro-inflammatory
ahajournals.org/doi/10.1161/AT…

.VUMC Pathology researchers have demonstrated that a cluster of microRNAs — small pieces of RNA that regulate gene expression — work in a type of immune cells called macrophages to help protect against metabolic defects in obesity.

Cell Reports Pua Lab

spr.ly/6018PxCEj

Thank you to ACIR for the awesome overview! Check out below for the great science summary and to meet the researchers Philip Lab 👇

Excited to share our findings on early CD8+ T cell differentiation in tumors! Dysfunction can occur just hours after activation and coincides with large scale chromatin remodeling prior to cell division. Philip Lab Vanderbilt MSTP Check out link below 👇

We are excited to share our work published today in Nature Immunology by Michael Rudloff, the whole @PhilipLabVandy team Vanderbilt University Medical Center, and in collaboration with our fantastic computational biology collaborators Doron Betel and his group Weill Cornell Medicine. 1/7
nature.com/articles/s4159…

#ScienceSaturday When does T cell dysfunction start? It turns out, within hours of contacting tumor and even before T cell proliferation! Intriguing article by Michael Rudloff, Mary Philip and colleagues Vanderbilt Hem / Onc demonstrating this and hypothesizing that this may be due to

Celebrating a successful dissertation defense by, now former, grad student Brenna Appleton, PhD (in white). Congrats and well deserved!!

Excited for my first ACSM conference since the last Denver meeting! I’m starting my lab at University of Houston this fall and I’m recruiting a research technician and future graduate students. If anyone is interested in connecting in Denver, please don’t hesitate to reach out! #ACSM23

Really excited to share the work I have done with Haydn Kissick over my PhD! In this work we show that CD8 T cell activation and differentiation in cancer happens in two distinct phases. Tweet-orial below summarizes the main findings we have described. cell.com/immunity/fullt…

Very happy to share our work on T cells in one of the deadliest side effects of anti-cancer therapy, immune checkpoint inhibitor-myocarditis out today in nature mentored by BalkoResearchLab Javid Moslehi ; read on for a short summary! Vanderbilt MSTP
nature.com/articles/s4158…

Excited to share our latest preprint from the Jeff Rathmell lab! We found that fever temperatures alter CD4 T cell metabolism and are mutagenic. Thanks to all coauthors for their help in this exciting project!😁

Postoak et al. describe a novel role for the lipid kinase Vps34 in controlling the production of self-peptides optimized for selection of CD4 but not CD8 T cells. bit.ly/3chRE63

From our #Tolerance & #Autoimmunity collection: bit.ly/3s1wMnT

Grad student Natalie Favret giving a great talk at the first ever VUMC_VCI retreat!