Online Now: GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies dlvr.it/T69vLz

Salima Benbarche, Omar Abdel-Wahab (@AbdelWahablab), & collaborators including Robert K. Bradley & Sergei Doulatov show that GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in #hematologic malignancies.

🖨️ Out now in Molecular Cell!
bit.ly/3UErWfm

Abdel-Wahab Lab Sergei Doulatov Salima Benbarche Jose Mario Pineda Laura Baquero Galvis Molecular Cell Thank you Fred Hutchinson Cancer Center for highlighting the therapeutic potential of targeting GPATCH8!
fredhutch.org/en/news/center…

.Alex Edelman, Tina Fey, Jim Gaffigan, nick kroll, Last Week Tonight, & more will perform at Comedy vs Cancer at Jazz at Lincoln Center on 5/7. Every ticket purchase supports lifesaving #bloodcancer research at MSK. More: bit.ly/3SWivG4

(The lineup is subject to change.)

Happy International Women’s Day. So fortunate I pursued the path I designed for myself and immensely grateful to all the women who paved the way before me!
Thank you Memorial Sloan Kettering Cancer Center and all the institutions celebrating women today and every day.

Ecstatic to announce our lab’s new paper in Science Magazine in collaboration with Abdel-Wahab Lab and Nurix Therapeutics led by Skye Montoya, Jessie Bourcier (@jessie05866344), Mark Noviski and Hao Lu. Sylvester Comprehensive Cancer Center Memorial Sloan Kettering Cancer Center #science #biology #cancer science.org/doi/10.1126/sc…

Dear #pharmacology enthusiasts, don't miss the #ASPET2024 meeting and the opportunity to learn about the latest therapeutic discoveries. I will be presenting our work on targeting aberrant #splicing in cancer.

Congratulations to Omar Abdel-Wahab of Abdel-Wahab Lab for receiving the 2023 William Dameshek Prize at #ASH23 to honor his outstanding contributions in #hematology . Learn more about Dr. Abdel-Wahab's work in this article by Memorial Sloan Kettering Cancer Center: buff.ly/3GEYgHq

The recipient himself: Dr. Omar Abdel-Wahab (Abdel-Wahab Lab) 👏🏽👏🏽 #ASH23

#ASH23 News Daily Monday AM edition is out. Our piece ‘It’s time to sp(l)ice things up’ covers fantastic work by Salima Benbarche Abdel-Wahab Lab, which was presented at #ASH23 Plenary Session. ASH. Read it here: ashpublications.org/ashnewsdaily/n…

Natasha Szuber Juliana Perez Botero MD (she/her) 🌈

Congratulations Salima Benbarche Abdel-Wahab Lab on your #ASH23 plenary session - Synthetic Introns Identify the Novel RNA Splicing Factor GPATCH8 As Required for Mis-Splicing Induced By SF3B1 Mutations!! Memorial Sloan Kettering Cancer Center MSK Department of Medicine

An impressive talk by Salima Benbarche and the Abdel-Wahab Lab on the power of targeting splicing in leukemia… #ASH23 #ASH2023 #RNA

What a spectacular talk by Salima Benbarche in #ASH23 Plenary talk.. still awestruck by this amazing data! Congrats to Abdel-Wahab Lab and team !!

So proud of Salima Benbarche former member of my lab and now successfull member of Abdel-Wahab Lab for a great presentation at #ASH2023 plenary session !

Happening Now at #ASH23 : Salima Benbarche, PhD (Salima Benbarche) of Memorial Sloan Kettering Cancer Center presents at the Plenary Session on synthetic introns identifying the novel RNA splicing factor GPATCH8 as required for mis-splicing induced by SF3B1.

Read more: ash.confex.com/ash/2023/webpr…

Join Salima Benbarche, PhD, at #ASH23 TODAY at 2:45pm PST. She will discuss findings that demonstrate the power of synthetic intronic splicing assays for the discovery of novel factors and druggable proteins required by #leukemia -associated mutations in the RNA splicing factors.

SF3B1 mutations are common in ppl with #MDS , #CLL , and CH. At #ASH23 , Salima Benbarche of Abdel-Wahab Lab presented data showing that disrupting GPATCH8/DHX15 interaction could provide therapeutic benefit for SF3B1-mutant hematopoietic diseases. Memorial Sloan Kettering Cancer Center buff.ly/488BFhW