Data on Dato- encouraging! businesswire.com/news/home/2023…

The efficacy of #immunotherapy is mainly attributed to reactivation of CD8+ T cells that specifically recognize tumour antigens in a MHC-I-context. There is new evidence that CD4+ T cells can contribute to antitumour immunity, independent of their role as helpers and regulators…

About last night. A feast! They had to place a small table behind us for additional food plates which didn’t fit on the table. Amr knows how to welcome the guests to Cleveland!
It’s been fun!
NANETS

An analysis by So Yeon Kim Amin Nassar, MD & colleagues of treatment options for patients with stage III unresectable EGFR mutant #NSCLC showed consolidation EGFR TKI therapy yielded significantly longer disease free survival than durvalumab #ASCO23 #lcsm Smilow Cancer Hospital Yale School of Medicine Yale New Haven Hosp

#AACR23 Is #AEGEAN a sea change?

- Ph III neodj durva+chemo + 1yr durva post surgery v chemo alone in early stage NSCLC
- 70% stage III
- EFS HR 0.68, pCR 17% v 4%
- cis or carbo had equiv EFS
- ?females did not do as well for EFS or pCR - more data needed

OncoAlert #LCSM

2 for the price of..0!
Cambridge Press Elements in Molecular Oncology chapters on precision oncology in NSCLC- EGFR + beyond -available for download for free for 1 wk before paywall comes up
cambridge.org/core/publicati…

BFAST but be smart! Roy Herbst & So Yeon Kim discuss results of a phase III trial evaluating blood-based tumor mutational burden in patients with treatment-naive advanced-stage #NSCLC in @NatureRevCancer. #lcsm OncoAlert Smilow Cancer Hospital Yale School of Medicine Yale New Haven Hosp
nature.com/articles/s4157…

Credits to the whole team! Balazs Halmos Jun Yin Stephen V Liu, MD Haiying Cheng Patrick C. Ma, MD Chul Kim Karen Reckamp, MD, MS @dipeshuprety4 Misako Nagasaka

Extensive characterization of #METex14 NSCLC in #JTOCRR by Drs. So Yeon Kim Balazs Halmos. Included 21582 samples tested with NGS: METex14 seen in 533 (2.5%). Analysis noted common co-alterations in MDM2, HMGA2, CDK4 more common in MET altered vs wild type.
jtocrr.org/article/S2666-…