Stephen V Liu, MD(@StephenVLiu) 's Twitter Profile Photo

Report in JTO & JTO CRR shows efficacy of tepotinib in NSCLC with exon 14 skipping mutation detected by Oncomine Dx assay even when discordant results seen with ArcherMET assay.

jtocrr.org/article/S2666-…

account_circle
Vladmir C. Cordeiro de Lima, MD, PhD(@ClaudioVladmir) 's Twitter Profile Photo

Our study RELANCE/LACOG0118 is out at JTOCRR. Stage III NSCLC patients treated in the public health system in Brazil have a 2-fold increase in the risk of death compared to pts with private insurance. Time to change. Thanks to all coleagues and the GBOT. jtocrr.org/article/S2666-…

account_circle
Misty Dawn Shields(@drshieldsmd) 's Twitter Profile Photo

Thanks Stephen V Liu, MD for the shoutout on our 🚨Pub Alert 🚨in JTO & JTO CRR

Here’s the key 🔑 takeaways:
1️⃣ EGFR-RAD51 fusions are rare
2️⃣ osimertinib = effective/durable
3️⃣ know the coverage of panels
4️⃣ precision medicine changes lives

account_circle
JTO & JTO CRR(@JTOonline) 's Twitter Profile Photo

We are delighted to announce that articles published in are now indexed on Web of Science. First Journal Impact Factor is expected in June 2024! Read all articles here: jtocrr.org

We are delighted to announce that articles published in #JTOCRR are now indexed on Web of Science. First Journal Impact Factor is expected in June 2024! Read all articles here: jtocrr.org #IASLC #openaccess
account_circle
GBOT Alerta(@GBOT_Alerta) 's Twitter Profile Photo

🇧🇷RELANCE/LACOG0118 publicado online no JTOCRR. Pacientes com CPCNP ECIII tratados no serviço público têm 2x mais chance de morrer. Causas: diagnóstico tardio e acesso limitado a novos tratamentos? Grande esforço de vários colegas, do LACOG e do GBOT.
jtocrr.org/article/S2666-…

account_circle
Jarushka Naidoo(@DrJNaidoo) 's Twitter Profile Photo

Proud to share our paper in JTO & JTO CRR on the Genomic Landscape of NSCLC in 🇮🇪:

- 2052pts (23 hospitals) had central NGS, identifying KRAS in 32%; EGFR 8.8%; BRAF 3.5%; met exon14 2.6%; HER2 1.7%
- Fusions ALK 2.1% RET, ROS1<1%

OncoAlert

jtocrr.org/article/S2666-…

account_circle
Damir Varešlija(@damirvareslija) 's Twitter Profile Photo

Great to see this important and timely study on the genomic landscape of lung cancer in Ireland. Findings like these are crucial for helping us understand our population. Great work Jarushka Naidoo and colleagues! JTO & JTO CRR

account_circle
Stephen V Liu, MD(@StephenVLiu) 's Twitter Profile Photo

Case report in outlines acquired resistance for NSCLC. Received repotrectinib as 5th line therapy and developed ROS1 G2032R resistance (resected). Then developed ROS1 L2086F mediated resistance that responded to cabozantinib (PR > 7m).

jtocrr.org/article/S2666-…

account_circle
Jarushka Naidoo(@DrJNaidoo) 's Twitter Profile Photo

RELAY Trial (Erlot+Ram 1L EGFR+ NSCLC) analysis by exon19 variant :
- most common ex19del variant E746_A750del(67.2%)
- mPFS 18 v 12.5 uncommon (nonE746) v common (E746) variants
- ⬆️PFS in pts w common variants w erlot/ram

@Oncoalert IASLC
jtocrr.org/article/S2666-…

account_circle
Michael Duruisseaux(@MDuruisseaux) 's Twitter Profile Photo

👇 interesting case of sotorasib-induced hepatotoxicity after IO, hepatotoxicity recurrence with soto rechallenge after DOC/RAMU in a pt with G12C NSCLC. Adagrasib given safely (full dose) with durable response (including CNS)
KRASKickers
jtocrr.org/article/S2666-…

account_circle
Stephen V Liu, MD(@StephenVLiu) 's Twitter Profile Photo

Real world data from US Veterans with G12C NSCLC treated with sotorasib in JTO & JTO CRR. In 128 pts, RR 34%, mPFS 6m, mOS 12m with 37% of pts needing dose interruption or reduction. Dose reduction was actually associated with better PFS/OS.

jtocrr.org/article/S2666-…

account_circle
Stephen V Liu, MD(@StephenVLiu) 's Twitter Profile Photo

Report on a pilot intervention to inform women undergoing screening mammography about lung cancer screening in JTO & JTO CRR. Patients were responsive to learning about dual screening - important efforts from Drs. Lye-Yeng Wong MD Leah Backhus MD MPH FACS

jtocrr.org/article/S2666-…

account_circle
Raffaele Di Giacomo, PhD(@sciqst) 's Twitter Profile Photo

Stephen V Liu, MD Captivating case report in the , highlighting the complexity of treating G12C NSCLC with evolving therapeutic agents. Sotorasib showing promise post chemo-IO but with notable hepatotoxicity challenges reinforces the need for tailored treatments based on patient…

account_circle
Raffaele Di Giacomo, PhD(@sciqst) 's Twitter Profile Photo

Stephen V Liu, MD Lizza Hendriks Nice findings by Dr. Lizza Hendriks and colleagues in , shedding light on the complex relationship between osimertinib plasma concentration and CNS control in NSCLC patients. This research underscores the importance of exploring multiple avenues for optimizing…

account_circle
Raffaele Di Giacomo, PhD(@sciqst) 's Twitter Profile Photo

Stephen V Liu, MD JTO & JTO CRR As a scientist with a focus on biomedical research, I find the case highlighted in to be a crucial reminder of the importance of monitoring for pneumonitis/interstitial lung disease when using adjuvant osimertinib in NSCLC patients. The capacity for early…

account_circle