Join us at #ReproT on 17th April to learn more about how g-estimation can strengthen causal inference in longitudinal data:

Sign up here: eventbrite.co.uk/e/causal-infer…

All welcome! Tabea Schoeler ReproducibiliTea UK Reproducibility Network Swiss Reproducibility Network

Can we use biobank #EHRs to study the genetics of drug efficacy? 💊🧬
How to best model drug response and longitudinal biomarker progression in an unbiased manner? 📊
Do #PRS predict treatment outcomes?
Check out our new preprint doi.org/10.1101/2024.0… and the thread 🧵 below👇

Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications medrxiv.org/cgi/content/sh… #medRxiv

Join us at #ReproT on 21 March to learn about synthetic datasets!

Dan Major-Smith (@djsmith90.bsky.social) will discuss how synthetic datasets can promote open science when data (e.g., longitudinal cohort studies) can't be shared.

Sign up: eventbrite.co.uk/e/using-synthe…

Tabea Schoeler Alex Kwong UK Reproducibility Network Swiss Reproducibility Network

Just out now! Our pheWAS-based clustering of instrumental variables can reveal heterogeneous causal effects & confounding. Plus facilitates the interpretation of the underlying mechanisms. We apply it to the BMI->education relationship. Spearheaded by Liza Darrous

NEW PREPRINT!

We have a new MR method called MR-link-2, which we validated extensively.

Interested in Mendelian randomization?
A🪡 below
medrxiv.org/content/10.110…

🧬 Excited to share our preprint on #telomere epidemiology medRxiv 👇🏻

We delve into the complex interplay of telomeres, health traits, diseases, and lifestyle factors using a bi-directional MR framework 📊🧵
medrxiv.org/cgi/content/sh…

Our paper on genetic transmission and genetic nurture effects for conduct problems is now published in Molecular Psychiatry molecularpsychiatry! This version includes new analyses nature.com/articles/s4138… 🧵 1/6

The importance of theory and hypothesis formalization for reproducibility

Come and join the next #ReproT on 13 December to hear Dr Matthew Vowels for a discussion on this!
👇
Sign up: t.ly/WdxOC

Dr Jessie Baldwin Swiss Reproducibility Network UK Reproducibility Network

We have a new preprint out! Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

osf.io/preprints/psya…

'Forming a ratio does not 'adjust' for the denominator in the sense of holding it constant...

We demonstrate that associations arising in ratio GWAS can be entirely denominator-driven' 🤯

DON'T USE RATIOS WHERE THE DENOMINATOR VARIES BETWEEN PARTICIPANTS!

#EpiTwitter

🧬 Exciting Updates in Genomic SEM Package! 🧬
We're thrilled to announce that two incredible new functions are now available in the Genomic SEM package. Let's dive into what these functions do and where to find tutorials for them. 🧵👇

New preprint from my group led by Yuchang Wu Zhongxuan(John) Sun. Almost every recent Alzheimer's GWAS combines clinical AD diagnosis and proxy phenotypes based on parental health survey. We report major limitations in the current practices of GWAS-by-proxy (GWAX)
biorxiv.org/content/10.110…

Louise Arseneault
SGDP Centre KCL
Are you age => 18 yrs, live in London, never used cannabis or only tried ir 2-3 times. Please scan the barcode below and complete our Cannabis&Me online survey. All participants will enter a Christmas ruffle!