One of the most important and practice-changing piece this year.

Everyone treating patients with melanoma should read this‼️

Conclusions are supported by clinical trials data and real-world outcome.
Great work by Marco Donia & Vinay Prasad MD MPH 👇
(+link bit.ly/4bsv1VR)

Really great post on today's Drug Development Letter

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drugdevletter.com/p/fridays-gem-…

New post of the 'Friday's GEM' section of the Drug Development Letter !

A seminal trial in breast cancer led by George W Sledge MD

Check it out❗️drugdevletter.com👇

Vinay Prasad MD MPH Timothée Olivier, MD Fantastic post! Excited to for this new #ASCO24 series!

Great post in drug dev letter by Timothée Olivier, MD about what to look for in Laura trial #asco24

Strongly worry about these limitations.

drugdevletter.com/p/what-to-expe…

Heureux de participer au nouveau numéro dédié à l'oncologie de la Revue Médicale Suisse avec mes collègues Oncology Division - Geneva University Hospital❗️

'Interpréter un essai randomisé en oncologie : éléments clés en clinique'

revmed.ch pour le numéro complet!
+ ici : bit.ly/3ylr9Hy 👇

Let's get ready for ASCO-2024 and the LAURA trial❗️

➡️Osimertinib 'maintenance' after chemoradiotherapy in EGFR-mutated unresectable stage III lung cancer.

check out the drugdevletter.com👇
Alfredo Addeo MD Solange Peters Suresh S. Ramalingam, MD, FASCO Jarushka Naidoo Stephen V Liu, MD

Great essay by Vinay Prasad MD MPH on how to read clinical oncology papers. Ask:
-- Did they randomize?
--Is the control arm consistent with current practice?
--Is the endpoint of the study clinically important, or just a biomarker?

Alireza Mansouri Vinay Prasad MD MPH Equipoise... this quote is inspiring

How to read a cancer trial
Timothée Olivier, MD
drugdevletter.com/p/how-to-read-…

Really important article in the drug development letter

S Miller traces money through FDA Oncology workshops

drugdevletter.com/p/how-the-mone…

Out in The Lancet Oncology, the latest analysis by our colleague Dr Anita Wolfer head of the breast cancer clinic HUG and colleagues at Swissmedic - Project Orbis a collaborative parallel-review programme launched by U.S. FDA in 2019 to expedite patient access to cancer drugs.

Congrats to our colleague Dr Anita Wolfer and the Swissmedic team👏, providing insightful data about the Project Orbis from the Swiss 🇨🇭perspective!
Just out in The Lancet Oncology !👇

Does anyone know if brain MRI or other CNS imaging was mandated before enrollment in the LAURA trial ❓
Any link to protocol?

LAURA=osimertinib 'maintenance' after chemoradiotherapy of stage III unresectable EGFR mutated lung cancer, PFS = 1ry endpoint
Alfredo Addeo MD Stephen V Liu, MD

Senator Dick Durbin Dear Senator,
Here is a recent work Sruthi Ranganathan, Vinay Prasad MD MPH and I published in The Lancet Oncology that might interest you as well.

Access here: bit.ly/3QqKMUV
Interestingly, the temporary authorisation has not been renewed in Switzerland (EMA pending)

Sincerely

Important letter - linking to work highlighted by Vinay Prasad MD MPH Timothée Olivier, MD

This has implications beyond the FDA Oncology

This made my day! Properly explaining risk is an important part of the job. We can do a better job of it in melanoma without scaring people to death. This is what motivates my 'controversial' work! 🙏🏾

Start your research!
The 10th Peer Review Congress is only 16 mos away, on Sept 3-5 2025
See the call for research at
jamanetwork.com/journals/jama/…
The abstract submission portal will open in the Fall, and abstracts will be due Jan 31, 2025
JAMA Network METRICStanford The BMJ

Manni Mohyuddin & Aaron Goodman - “Papa Heme” take on overtreatment in plasma cell neoplasms! drugdevletter.com/p/fridays-gem-… via Timothée Olivier, MD & Vinay Prasad MD MPH

We are launching the editor's pick.
Each Friday we will pick a seminal article and discuss it.
Today is Aaron Goodman - “Papa Heme”
And Manni Mohyuddin
Timothée Olivier, MD
Subscribe to the drug development letter

drugdevletter.com/p/fridays-gem-…