How does Mcm10 activate an origin of replication?

Find the answer in our paper published today in NatureStructMolBiol. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉

rdcu.be/dIdI4

Great collaboration with Marta, Allie and John from John Diffley The Crick

Really happy to share our last work on Pol Epsilon, replicative gaps and sensitivity to PARP inhibitors ! Barts Cancer Institute (Queen Mary)

The lab’s first pre-print is out! ‘A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichment’ biorxiv.org/content/10.110…

My lab DKFZ is looking for excellent #MSCA #Postdoc to investigate #Genome integrity in the developing #brain . Fellowship covers living costs, family allowance, and connections to #MSCA community. Deadline May 13 - apply here. dkfz.de/en/postdoc-pro…

Delighted to share our pre-print identifying human DNA replication initiation sites on single molecules by Oxford Nanopore sequencing. Key findings 1/6
biorxiv.org/content/10.110…

Please RT: The Walter lab at Harvard seeks computational biologists to extend our work using AlphaFold to find new protein-protein interactions. Contact [email protected]
biorxiv.org/content/10.110…
predictomes.org

We have temporary fully funded postdoc or LRS position to join our lab The Crick working jointly with UCL IPLS to work on developing tools for measuring forces that position mitotic spindles and chromosomes. More info here: bit.ly/44jttuI. E-mail Maxim to discus.

📢NEW #Preprint , Brainchild of Jose Julián with Alessia, Peng & our amazing collaborators. Topics covered #ATG8ylation , #cell_wall_damage , #vacuolar_quality_control , #mechanostasis . biorxiv.org/content/10.110… Intrigued? See the 🧵for a summary:

📢Postdoc opportunity📢 Please RT.
Join us on a Wellcome Trust funded position at The ICR to study how unusual DNA structures affect eukaryotic replication.
Have experience in either biochemistry or cell biology?
Great! Apply by end of May👇👇👇
jobs.icr.ac.uk/vacancies/901/…

Excited to share (with my 8 followers) graduate student Ernst Schmid’s “SPOC” classifier, which can pick a good AlphaFold-Multimer prediction out of a crowd, and predictomes.org, a database of PPIs in the genome maintenance space.

biorxiv.org/content/10.110…

Last 3 days to apply!

Great to see Johannes Walter's (and Ernst Schmid's) predictome preprint out! The improvements on undertaking the virtual protein-protein interaction screens with AF2 are really cool. Can't wait to try the new classifier.
biorxiv.org/cgi/content/sh…

Reconstitution of human helicase loading with purified proteins and its biochemical and structural characterisation. This was a great team effort—special thanks to Jen, Vera Leber, and the entire Speck Lab.
biorxiv.org/content/10.110…

Human origin licensing reconstituted with purified proteins. Great collaboration with Florian Weissmann & John John Diffley. A cryo-EM tour de force from our Julia Greiwe.

Happy to share our latest story in Nature Cell Biology 🥳

In collaboration with the Steve Jackson Lab, we identify a transcription-coupled DPC repair pathway that depends on CSA/CSB but is independent of classical NER 🧬👩‍🔧

nature.com/articles/s4155…

Over the past few years my lab has developed new uses for reversible replication barriers in vitro. Emma Vontalge and Tata Kavlashvili outline our most up to date protocols in Nature Protocols. We hope the community finds this resource useful! 🧬🚦
nature.com/articles/s4159…

Don’t forget about our UK DNA replication meeting! Only chairs of the sessions invited - rest of the talks are for grabs from the abstracts. Come and share your work with us! #UKDNAreplication

Join us for this exciting Symposium featuring Replisome structure, Origin regulation, Chromatin replication, Replication stress and Replication in Cancer etiology/treatment. Stellar speaker lineup! MANY talks selected from abstracts.

We’re #hiring ! Multiple #postdoc positions will be available in my lab to study DNA damage response signalling from June onwards. Get in touch with your CV if interested. Please RT!