Join the innovative Translational Sciences group at #Biogen and be at the forefront of drug discovery. Leverage cutting-edge human genetics insights and collaborate with top-notch scientists to drive drug pipeline forward. Apply now! smrtr.io/kr3gC

Today on #worldOvarianCancerDay we are sharing insights on our work! Check it out!

The icelandic group had published an association between variants near the ABCC9 gene and voice pitch last year and we wondered whether the association would be found in Mandarin Chinese speakers, where pitch conveys meaning
science.org/doi/10.1126/sc…

For the purpose reproducibility and historical preservation, I am releasing today idat2gtc, a tool that replaces Illumina's AutoCall, allowing IDAT files from DNA microarrays to be processed, provided a cluster file is available github.com/freeseek/gtc2v… 7/8

Extremely excited and proud to have this work out! Joint with Manish Butte at UCLA Health, we developed an EHR-based algorithm to identify patients with rare, undiagnosed immune disorders. 1/3
science.org/doi/10.1126/sc…

SCZ cases had a higher rate of MetS (HR 1.95) driven by both antipsychotic medication use and genetic predisposition to higher BMI. Excellent team work by maris alver Silva Kasela Liina Haring Krista Fischer Laura Luitva & Märt Möls! CoMorMent REALMENT

INTERVENE researchers Brooke Brooke N. Wolford, PhD and Kristi were featured on the excellent We are doomed we are saved podcast. Check out the latest episode on PRSs!
Apple:
podcasts.apple.com/de/podcast/we-…
Spotify:
open.spotify.com/episode/4gOIgD…
Youtube:
youtube.com/watch?v=_eImY2…

Proteomics QTL results:
Olink (619 samples across 2925 proteins) and SomaScan (828 samples across 7596 proteins)
More info: finngen.gitbook.io/documentation/…

New FinnGen result datasets released this spring!
For FinnGen R10 (N=412,181), we have released:
▶️Coding variant association results (downloadable format)
▶️Gene-based burden test results of loss-of- function variants (LoFs)
▶️Proteomics QTL results (note a small subset, N<1000)

FinRegistry study examines register data covering the whole Finnish population. This dataset collection is now available from Findata! Kudos to Andrea ganna, Markus Perola 🇫🇮🇪🇪🇺🇦 and the whole FinRegistry team at FIMM and THL for enabling this.
#OpenScience
📰findata.fi/en/news/finreg…

Great GWAS paper diving deep into the contributions of germline variants to kidney cancer in 29k cases and >800k controls. I particularly love the discovery of a VHL 3' UTR variant, seen in ~10% of African and ~0.01% of European ancestries, that increase the risk of clear cell…

In a new article at ESR with Bernt Bratsberg and Ole Rogeberg, we analyze the relation between labor income and cognitive ability using admin data from Finland and Norway. Main result is in the title.

Open Access at OUP: doi.org/10.1093/esr/jc…

1/n

Sasha Gusev M. Bolton As a statistician who was not trained in genetics and who did not have any stake in success/failure of GWaS to begin with, I have always found it amusing when people choose GWAS as the field to show how things in science can go wrong due to bad use of statistics. Actually this is…

“Horizon Europe must be reinforced by focusing on the most effective programmes such as the European Research Council”

Emmanuel Macron stressed Europe should become “a continent that invests in breakthrough innovation & advanced fundamental research'.

sciencebusiness.net/horizon-europe…

Yes! The system works.

We accessed the data, processed, cleaned, and sent it back for others to use.

No gatekeeping.

All data should be accessible not by contacting researchers but via impartial, third-party institutions.

⚠️Don’t miss!!!!⚠️

🚨AIES mid-year meeting
📍Ministero della Salute
📆 June 11
👉registration: aiesweb.it/riunione-inter…

cinzia.dinovi Vincenzo Atella Pietro Biroli Gabriella Conti marco.bertoni.unipd Andrea ganna
#FrancescoSaverio #Mennini

'Move to Finland' they said. 'It'll be fun' they said.

📢 New pre-print!

We tried to understand why autoimmune disease and type 1 diabetes co-occur in families using nationwide registries and genetic data.

FIMM HelsinkiUni FinnGen #FinRegistry HiLIFE_Helsinki

👇👇👇👇

T1D and other autoimmune diseases (AIDs) co-occur in families. How parental AIDs impact T1D risk in offspring and how much of the familial risk is explained by HLA and non-HLA variants? 👩🏻‍🦱🧔🏻‍♂️👶🏻
Find out more from this thread 🧵 and our new preprint ⬇️!medrxiv.org/content/10.110…

way to go!!