Advances towards genome-based acute myeloid leukemia classification: A comparative analysis of WHO-HAEM4R, WHO-HAEM5, and International Consensus Classification
Free access: doi.org/10.1002/ajh.27…
#hemepath #leusm #AML

Advancements and Challenges in the Treatment of #AML | American Society of Clinical Oncology Educational Book ascopubs.org/doi/10.1200/ EDBK_438662 #leusm #asco2024

Bone marrow #inflammation in haematological malignancies
nature.com/articles/s4157…
#MDSsm #MPNsm #leusm #MMsm

👉👉👉It’s time to talk about revised endpoints for Myelofibrosis clinical trials in the new era of novel tx. 📣 We must move beyond/add to spleen+sxs. ➡️We must focus on OS, PFS, EFS,blast % improvement,anemia improvement, bridge to alloSCT #MPNSM
Adam Mead Claire Harrison

RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives | Blood Cancer Journal nature.com/articles/s4140…

CD7 targetable 🎯and is expressed in ~30% of AML. Expression may change at disease progression, highlighting the need to retest. Invaluable help from super hempath Sanam Loghavi, MD صنم لغوی 🔬🧬 Sa A Wang, MD! Naval Daver, M.D. Tapan Kadia Hagop Kantarjian,MD

Read more here 👉 onlinelibrary.wiley.com/doi/10.1111/bj…

Can we switch on a natural killer against #acute_myeloid_leukemia ( #AML )?
There is no effective immunotherapy for AML. However, a new study takes a step towards identifying a potential immuno-target in AML.
haematologica.org/article/view/h…

IFN-γ and CD38 in AML: a T-cell engagement made in heaven?
ow.ly/ZcEM50Rjiob #immunobiologyandimmunotherapy

Please also check out the recently released Chronic myelomonocytic #leukemia : 2024 update on Dx, risk stratification and management from Drs. Mrinal Patnaik & Ayalew Tefferi
Including #CMML clonal evolution & unique associations
Free access: doi.org/10.1002/ajh.27…
#hemepath

Weekend review

1/9 Clinical significance of RAS mutation in AML

Hairy cell #leukemia 2024: Update on diagnosis, risk-stratification and treatment
Including Dx & treatment algorithms and guide to cytologic features of HCL, HCL variant, splenic MZL & splenic diffuse red pulp #lymphoma !
Free access now: doi.org/10.1002/ajh.27…
#hemepath #HemOnc

Dasatinib + Venetoclax is safe & effective in newly diagnosed #CML in CP, but no better than single-agent dasatinib; longer follow-up needed to evaluate impact on TFR:
MD Anderson Cancer Center #Leukemia
ACS Journal Cancer
acsjournals.onlinelibrary.wiley.com/doi/epdf/10.10…

AML with myelodysplasia-related genetics can be combined as a single group encompassing MR-defining gene mutations and cytogenetics. ow.ly/IJVx50RbKgI #myeloidneoplasia #healthservicesandoutcomes

T-cell dysfunctions in myelodysplastic syndromes | Blood | American Society of Hematology ashpublications.org/blood/article/…

1/9 Weekend review
#Menin_inhibitors #leusm #MLL #KMT2A
MLL- rearrange acute leukemia (AL).
Recently there has been lot of interest in the management of MLL-rearranged acute leukemia, courtesy development of novel Menin inhibitors.

Brief overview on MLL gene re-arranged AL in…

Machine learning methods: a new study examining validation of the European LeukemiaNet 2022 criteria and genomic clusters in older adults with #acute_myeloid_leukemia . haematologica.org/article/view/h…

Personalized Prediction Model to Risk Stratify Patients With Myelodysplastic Syndromes
doi.org/10.1200/JCO.20…
Journal of Clinical Oncology MDS Hub MDS Foundation AA&MDSIF International Consortium for MDS (icMDS) Mikkael A. Sekeres MD, MS Aziz Nazha

Checking out the #AACR24 session on the immune microenvironment in hematological malignancies? Read the recent review from speaker Iannis Aifantis on #inflammation as one of #cancerhallmarks in myeloid neoplasms:
bit.ly/3xuKK7J AACR

# Weekend review
1/6 Differentiation syndrome (DS) with targeted therapies for myeloid malignancies

DS characterized by non-infectious related fever, weight gain sec to third spacing (pleural/pericardial effusion) and renal insufficiency.

Historically, known to occur with…

Myelodysplastic neoplasms evolving from inherited bone marrow failure syndromes / germline predisposition syndromes… pubmed.ncbi.nlm.nih.gov/38301422/ #ContextrelevantMDS #GPS #IBMF Mayo Clinic Comprehensive Cancer Center Joseph D. Khoury, MD, FCAP