Finally, Taylor Swift explains her own theorem.

CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments
Use Agent 'to facilitate the process of selecting CRISPR systems, designing guide RNAs, recommending cellular delivery methods, drafting protocols, and designing validation experiments to confirm editing…

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in Cell Genomics today, led by Adam de Smith, Lara Wahlster, Soyoung Elizabeth Jeon, Fulong Yu, Charleston Chiang, & colleagues:
cell.com/cell-genomics/…

Thanks James Zou for the support! I work on integrating #GWAS and #FunctionalGenomics . I also develop general #MachineLearning algorithms, for adaptive inference, multiple testing, etc. DM me if you are interested or have faculty job opportunities😉

Wonderful to have our paper on a MECOM-regulated gene network in human hematopoietic stem cell maintenance and leukemia published in Nature Immunology! Terrific work from our group led by Richard Voit, Tao Liming, and Fulong Yu:

nature.com/articles/s4159…

.Vijay Sankaran is a rockstar - Harvard Medical School Professorship named after current Dean George Q Daley!
Vijay was my Harvard Medical School *sub-intern* while I was an intern Brigham and Women's Medicine Residents.
Many congrats, my friend!

Meanwhile, the single cell field

-Can you send us your presentation a week before the conference?
- No, i'm still working on it

Interested in how cellular barcoding can help us better understand and treat human diseases?

Please check out this review from Dr. Len Zon, Jonathan Weissman's Lab, and I in Science Magazine today: science.org/doi/10.1126/sc…

Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population medrxiv.org/content/10.110…

Did you know? There are hundreds of datasets and 29M+ cells on #CZCellxGene to help accelerate #SingleCell research:

Learn more 🧵 cellxgene.cziscience.com/landing-page?u…

This was requested by reviewer 3

Grateful to Nature Genetics for this nice highlight of our recent paper (nature.com/articles/s4158…):

Mapping genetic variants to cellular contexts:
nature.com/articles/s4158…

1/Data available 'on reasonable request' almost always a lie. Mirko Gabelica, M.D,PhD Livia Puljak identified 1792 papers which claimed data available 'on reasonable request'. When asked, authors provided the data for only 7% of these cases. HT Benjamin Haibe-Kains sciencedirect.com/science/articl…

Team work as always. Many thanks to my great mentor Katalin Susztak and talented collaborators!
Hope everyone enjoy reading it!

SCAVENGE users, we added a wiki page for fine-mapping processing from GWAS summary statistics, where you can find a general strategy and corresponding code we used (github.com/sankaranlab/SC…), thanks to our fine-mapping expert liamcato 😃. Please let us know any questions you have

We're looking for new talent and team-players to join our lab! We have multiple positions open, including for a new lab manager, junior bioinformatician and postdoc! All on the crossroads of #spatialOmics #Oncology #technology See drieslab.com/Join%20Us/ for info. Feel free to RT

Fulong Yu & Vijay Sankaran present a computational method curating genetic associations from GWAS & #singlecellseq genomic data. Applying it to #hematopoeisis , they found monocytes that ⬆️ risk for #COVID19 & lymphocytes that predispose to acute #leukemia . ms.spr.ly/6014bdnmy.

Extremely excited to share our work on #V2F method SCAVENGE for the disease/trait relevant causal cell type/state identification using single-cell epigenomic data nature.com/articles/s4158… out now in Nature Biotechnology. The R package can be found github.com/sankaranlab/SC….