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Online Now: Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis dlvr.it/T4bwCc

Very interesting work! So much renewed interest in supercoiling and topology recently!

⚠️ BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.

Genome Biol 25, 40 (2024)
doi.org/10.1186/s13059…

Previously, we and others had found that in interphase the human genome is surprisingly unknotted/unentangled. Now we report that in mitosis chromosomes are self-entangled!
Led by Erica Hildebrand (not on X) Kirill Leonid Mirny 4DNucleome

Postdoctoral position in the Hunter lab studying BRAC2 functions in mammalian meiosis. Join the amazing environment at the University of California, Davis. An unrivaled concentration of groups working on genome stability & reproductive biology. Apply at: recruit.ucdavis.edu/JPF06362

Our MEDUSA paper was published today in Nature Chemical Biology! This is an approach for identifying death-regulatory genes, which we used to clarify different ways cells die following DNA damage. Congrats to Megan Honeywell Morningside Graduate School of Biomedical Sciences and to the other authors!

rdcu.be/dA4uj

Like — if you like unentangled fractal interphase. Repost — if you prefer knotted mitotic bottlebrushes.

Amazing 2-year collab with Erica Hildebrand, Job Dekker Job Dekker , Leonid Mirny Leonid Mirny ! HUGE THANKS everyone involved!!

Reminder: I will move to Threads, follow me there!

nice work from Brad Bernstein and Anders Sejr Hansen labs.

Go TADS!

cell.com/action/showPdf…

Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by Mariana Noto published Science Magazine addresses this fundamental question (1/n)
science.org/doi/10.1126/sc…

Amazing AM talks so far #CEI2024Symp @CEI-FCCC
Fox Chase Cancer Center Rani George Lab Job Dekker ME Torres-Padilla