A new paper from Zhimin Lu revealed that TERT was dephosphorylated by the protein phosphatase activity of the gluconeogenic enzyme FBP1, leading to inhibition of TERT nuclear translocation and telomere function. Free to read link at rdcu.be/dCMu9

A new paper developed a massively parallel screening platform for studying sensitivity of human signal peptides to Sec61 inhibitors. Free to read link at rdcu.be/dCMsx

So excited to see our work on 'Profiling the proximal proteome of the activated μ-opioid receptor' using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort!
nature.com/articles/s4158…
#TeamMassSpec #Proteomics #GPCR

I am excited to share that my first first-author publication from my graduate work with Drew Adams is out in Nature Chemical Biology! Here, we used many small molecule probes to spotlight an underappreciated role of XPO1 as a chromatin factor: nature.com/articles/s4158… (1/9)

I'm thrilled to share, our work is online now Nature Chemical Biology. Huge thanks to Ruma Banerjee, Shah Lab Costas Lyssiotis and all authors Rashi Singhal Sumeet A Solanki Sydney Alibeckoff Hannah Bell and others.rdcu.be/dBSCb

A new paper reports the de novo design of amyloidogenic peptide traps. Read it here rdcu.be/dB3Ie

Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) Nature Chemical Biology! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/
rdcu.be/dBZKx

A new paper reports the design of synthetic transmembrane proteins to regulate a target cytokine receptor. Free to read link at rdcu.be/dBTCy

A new paper from Solid-State NMR of Complex Materials and Catalysts sapun p Thomas Michaels reveals a crust-like β-sheet structure is formed on the surface of FUS droplets during aging. Free to read link at rdcu.be/dBTAF

How benchmarking challenges and data in the public domain will guide development in AI-based methods and breakthroughs in #drugdesign on a scale analogous to that seen for protein fold prediction?
Matthieu Schapira Rachel Harding Cheryl Arrowsmith Levon

nature.com/articles/s4158…

💊 Accessing natural vaccine adjuvants. 💉
nature.com/articles/s4158…
👍 Thanks Vincent Courdavault for this collaboration to write a spotlight Nature Chemical Biology on the awesome Anne Osbourn lab report (nature.com/articles/s4158…) 👏
BBV Lab Recherche et Innovation – Université d’Angers​ Faculté Santé Angers CHU Angers

A new paper reports the development of artificial mechanoreceptors (AMRs) which reprogram membrane non-mechanoreceptors to sense cell adhesion force. Free to read link at rdcu.be/dA6lF

Our MEDUSA paper was published today in Nature Chemical Biology! This is an approach for identifying death-regulatory genes, which we used to clarify different ways cells die following DNA damage. Congrats to Megan Honeywell Morningside Graduate School of Biomedical Sciences and to the other authors!

rdcu.be/dA4uj

Insightful take on our recent tRNA display work. Thank you to the authors for putting our science into context. nature.com/articles/s4158… (tRNA display) nature.com/articles/s4158… (comment). I agree, the next big challenge is ribosomal bond formation engineering in live cells.

A new paper reports a selective, aspartate-targeting covalent inhibitor of K-Ras-G12D, commonly found in pancreatic cancers. Free to read link at rdcu.be/dA6jx

Excited to share my postdoc work out in Nature Chemical Biology!
We explored the preferences and efficiencies of ATP pathways in cells and tissues. By quantifying metabolic flux and proteomics, we found that respiration makes ATP faster per enzyme mass than glycolysis🧵nature.com/articles/s4158…

A new paper uncovers the molecular details of antiviral drug recognition and membrane translocation by a concentrative nucleoside transporter CNT3. Read it here rdcu.be/dz6cS

A new paper identifies adipose triglyceride lipase (ATGL), an enzyme in fatty acid metabolism, as a negative regulator of the noncanonical inflammasome. Free to read link at rdcu.be/dz6bS

Our March issue is live!

nature.com/nchembio/volum…

The cover image captured by Henry Kilgore et al. shows that different condensates and cytoplasmic organelles harbor distinct chemical environments that influence the distribution of small molecules