Preprint: A single-cell transcriptomic atlas of the lungs of patients with pulmonary #Tuberculosis
researchsquare.com/article/rs-275…
This is the 1st single-cell transcriptomic landscape of the human lung after TB infection, showing disease-associated cell type-specific molecular profiles..

Here it is, 'da_tracker', an analysis workflow for quantitative single cell and single phagosome tracking, from time-lapse confocal microscopy datasets. It is developed in PyimageJ so free and open-source. biorxiv.org/content/10.110…

I am excited this is now published with eLife - the journal.
LRRK2/actin cytoskeleton/synapses is a favorite recurring theme of mine 😊. A fun collaboration with Elisa Greggio

'LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton' doi.org/10.7554/eLife.…

#mBio Editorial: History shows that science is fragile and vulnerable to theocratic, ideological, and authoritarian forces. In this moment of crisis, it is important for all scientists to become foot soldiers in the defense of science. Arturo Casadevall journals.asm.org/doi/10.1128/mb…

Happy to share with you my PhD paper highlighting the role of LC3B on HIV-1 entry ! Very thankful to Espert Lucile for those 4 fantastic years in IRIM !!
Huge thanks to all the people involved in this work and to the funders !
Definitely something to celebrate 🎉🎉

It’s out! We use internal tags to illuminate SARS-CoV-2 Envelope (E), report its interactome by BioID, find viral sequences and cellular factors controlling ER-export and Golgi-to-lysosome traffic and show E deacidifys lysosomes to aid viral replication. science.org/doi/10.1126/sc…

🎉Big day for the lab yesterday. Very proud of our newly minted PhD Beren Aylan The Crick A bright future ahead Beren!🤩 thanks to Trude Helen Flo R Ketteler for being excellent examiners

I can’t believe it’s our 6th meeting already! Calling all host/pathogen researchers for the definitive annual get-together, where you don’t need a microscope to see and be seen! 🦠 🧫 🔬 🍷

Very glad that this is out! This work started as my last project with Mark R Cookson (he/him/his) and was finished in the BP lab 🤟!! 🧵below!!
biorxiv.org/content/10.110…

💥One of my favourite meetings (the 6th one!) Great community of cell biology and infection. Lots of opportunities for early career researchers to present. Please RT 🙏

Important read for all of us studying cell-autonomous defences to pathogens. The guns (here lysosomes) each cell type has will be different AND (!) be loaded differently (aka differ in function and response) within a cell type. Yep, diversity in biology at its best! 😬😅😎

What a paper by Xiaochen Wang's group 👏👏👏!!

They discovered a protein (HPO-27 in C elegans, MROH1 in mammalian cells) responsible for lysosomal tubule fission.
nature.com/articles/s4158…

A great opportunity in Barcelona, I highly recommend Oriol’s lab, inspiring environment for your PhD. And very cool project. Do apply👇

🎉We’re excited to announce that Tientcheu Leopold an Ass Prof/Postdoctoral Researcher with us has been awarded a Crick Africa Network Career Acceleration Fellowship.

He will be working with Max Gutierrez The Crick & @SutherlandTB at our Unit on his #TB research.

👉🏾 bitly.ws/3gNEU

Leopold Tientcheu will be collaborating with Max Gutierrez at the Crick and Prof Jayne Sutherland at @MRCUnitGambia to study how people’s immune profiles affect their responses to tuberculosis (TB) treatments.

The Crick Africa Network has appointed eight new fellows! 🎉🌍

Meet our new @LifeArc1-funded researchers and see what they’ll be working on over the next four years.

UCT | Stellenbosch University | WACCBIP | MRC/UVRI and LSHTM Uganda Research Unit | MRC Unit The Gambia at LSHTM

crick.ac.uk/news/2024-03-2…

Pre-announcement: opportunity to apply for data and digital platform resources that will support, manage, link, share and access data at scale for biomedical, health and care research within remit of MRC, or NIHR Research or both.

Opens 9 April➡️ orlo.uk/lbSUq

Join us in commemorating TB day 2024 by learning about drug resistant forms of the disease. In this detailed review we examine burden, gaps and innovations in care!

Single-organelle resolution approaches have the potential to advance our knowledge of the heterogeneity of #lysosome function.

Max Gutierrez & claudio bussi propose a 'lysosome states' concept that links single lysosomes to function.

plos.io/3xatAMA

English spring at its best…