science.org/doi/10.1126/sc…

Really happy for this great story to be published - new insights both into the development of brain asymmetry and into the Wnt signalling pathway. Thanks and congrats to all authors of a very collaborative study!

science.org/doi/10.1126/sc…
Left-side story-Cachd1, Wnt Signalling and Asymmetry
Our new paper in Science provides new insights into the development of brain asymmetry and the Wnt signalling pathway. Thanks and congratulations to all authors on this very collaborative study.

A recent publication led by Roberto Mayor, Delan Alasaadi (first author and CDB alumnus) & others, examining hydrostatic pressure’s vital role on neural crest development is featured on the cover of Nature #Cell #Biology . Roberto Mayor Lab #cellbiology UCL Faculty of Life Sciences UCL Centre for Integrative Anatomy @jstdyll

☕️ My read for the weekend!
As usual, in this issue too, you ‘ll find excellent science in diverse cell biology areas!
👑Bonus for my #stemcell / #devbio friends: #HydrostaticPressure in development; #hematopoietic #aging ; #mechanobiology of #organogenesis

nature.com/ncb/volumes/26…

Exciting upcoming conference: Freiburg Spemann-Mangold Centennial Symposium
16th-19th September 2024

❗️Abstract deadline 3rd May:  elsevier.com/events/confere…

👇👇👇

#NewProfilePic

Many congratulations to Delan Alasaadi Delan N Alasaadi Roberto Mayor Lab, winner of this year’s British Society for Developmental Biology Beddington medal. Delighted to see that his beautiful work was supported by a The Company of Biologists travelling fellowship.

👋🏾Our April issue's live!
Cover: #HydrostaticPressure in #NeuralCrest

👉🏼Comments: #ElectronMicroscopy & #actin networks
🔬: #mechanobiology #neurodegeneration #ferroptosis #necroptosis #lipolysis #TranscriptionalRegulation #PancreaticCancer #SARSCoV2
nature.com/ncb/volumes/26…

Happy to see our work on How Hydrostatic Pressure controls Development via Yap in the cover of Nature Cell Biology Nature Cell Biology. Congratulation to Delan Alasaadi Delan N Alasaadi for the design and thanks to Julien Marcetteau for the image. To see the paper go to: nature.com/articles/s4155…

Thank you 3D Matter Made to Order for the invitation to participate in this excellent meeting. Great science (I learned a lot), beautiful place and perfect organisation!

💫NEW: Delan N Alasaadi, Roberto Mayor Lab & co report the role of #HydrostaticPressure in regulating #embryonic competence in the developing #NeuralCrest .
nature.com/articles/s4155…

20 years of the 'Latin American Society for Developmental Biology' LatinAmerica DevBiol

Well..we can look for the odd #gene / #GRN to explain #GeneExpression in development, even find one, but the answer might lie somewhere else, in the cell physical environment: Delan N Alasaadi Roberto Mayor Lab nature.com/articles/s4155…
#Xenopus #HydrostaticP #NotInTheGenes #CellsRUs #Beautiful

Thank you Hao Yin for the excellent summary of our work. I would only add that we showed that elevated hydrostatic pressure affect neural crest in Xenopus, mice and human organoids. see here: nature.com/articles/s4155…

How do cells choose an identity in the developing embryo?
⬆️ hydrostatic pressure inhibits signaling through transcriptional coregulator Yap, preventing differentiation into #neuralcrest in frog, mouse & human brain cell models.
Delan N Alasaadi Roberto Mayor Lab
ow.ly/KBum50R2ym5

Stuck in Santiago, Chile after British Airways cancelled my flight last night. Last communication from them was 9.20am this morning. It’s now 16.25pm and I have no idea when I’ll be flying home

Amazing line of speakers to celebrate the Mangold-Spemann Centennial organizer paper (Self-Organization in Biology, 16-19 September 2024, Freiburg, Germany). Abstract will be selected for talks. Deadline 3 May 2024
elsevier.com/events/confere…

Great LASDB LatinAmerica DevBiol meeting in Valparaiso Chile, we learned science, we meet old friends and made new ones…of all kind...only in Valparaiso!!!

Congratulation Nicolás Cumplido !! The first place of the talk awards. Hox genes and tail fin evolution LatinAmerica DevBiol International Society of Differentiation EMBO #EMBODevBio SBDch

#YAP links #Lumenogenesis with #EmbryonicCompetence 😎

Mechanosensitive #NeuralCrest induction in early #Embryogenesis

#YAP & Wnt signaling suppressed by (naturally or artificially) elevated Hydrostatic pressure during embryonic cavity #Blastocoel formation

Mind-blowing…