In the latest episode of The Social Radars, we chat with Kyle Vogt, co-founder of Cruise and Twitch. If you like complicated technical problems, this is the interview for you, because that's what he works on.

pod.link/1677066062/epi…

Never thought we'd have to say this, but at Descript we firmly believe that you, your tools, and your work should never be crushed, smashed, or smushed.

It's OK not to have all the answers.

Controlability that holds up to scaling. 🤌

Platforms like this are incentivized to make you think the world is falling apart. Resist the blue pill.

'You just type in a prompt -- all skill is gone'

Positive move by the administration for those in favor of innovation and startups.

Profluent has successfully edited human DNA with an AI designed gene editor.

Remarkable for many reasons, particularly the future it points to: one where AI designs specifically what’s needed to cure diseases. Coverage from The New York Times below in thread.

Say hello to OpenCRISPR.

Profluent's AI-created gene editor, fully developed using Profluent’s large language models, consisting of a Cas9-like protein and guide RNA.

nytimes.com/2024/04/22/tec…

Yesterday GrowSF saw an incredible number of new Twitter followers, newsletter subscribers, and donors. Thanks, Jackie, I’m serious!

If you want to help us put forward non controversial ideas that everyone can get behind, donate to GrowSF!

growsf.org/donate/

Fraser and I hung out to talk about our experiences with Devin, the autonomous engineer, and what it implies about AI product building. Later, we get into the innovator's dilemma and the lessons of the .com era.

hallwaychat.co/episodes/devin…

I enjoy these free flowing product jams between fraser and Nabeel Hyatt

pca.st/episode/1840a0…

It's one thing if Jobs was saying this about Apple.

It's an entirely other thing for a payment processor.

Well said, there are too many ugly things in the world. And there are immeasurable benefits to you, your culture & customers when you value the craft.

A defining feature of the age of AI is the “fog of war” of not knowing what’s going to happen next in the market.

This post I wrote as an entrepreneur back in 2013 feels relevant again and I find myself using it as a lens lately.

nabeel.medium.com/28b5c0391cec

This was a lovely discussion. Nabeel Hyatt and I talk through when a model has differentiated value and when it becomes a commodity.

Some good war stories from David Luan, one of the real one’s, on early OpenAI & now with Adept.

Good reminder not to obsess too much about your competitors, you have no idea what they are going through themselves.

latent.space/p/adept

It's unfortunate that we have an 'open in default browser' ecosystem but not a 'default podcast' or 'default reader'

Hurts innovation.

Multiple times a week I end up copy/pasting a link here into my podcast player and searching for the episode.
cc Arc Chrome

“In January 2023 Profluent published research detailing for the first time how large AI models can generate complete proteins that don’t exist in nature, yet function as well as proteins that evolved over millions of years. This model was equivalent in size to GPT-2. Large AI…

Profluent is foundational models applied to biology.

And seeing what Ali Madani and his team have accomplished already is astounding. First target: Precisely designed CRISPR gene editing. Excited for them & what they'll help the world do.

Built a 'game' idea.
COTUS: Pick a president, play through history, try not to mess it up.
chat.openai.com/g/g-lJa3cwbe3-…

Was chatting at GDC with some friends about AI. I mentioned the game Reigns as an example of feedback loops.

About 30 mins after I got home, I ended up just…