Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input by Ka Yang, Steven P. Gygi Gygi Lab, Qing Yu, et al at Harvard Medical School dlvr.it/T4T4TM

A huge shout out to our collaborators at Biogen too. It was an awesome teamwork.

I just voted. #TeamMassSpec Lingjun Li Research Group Ling Hao Qing Yu Ying Ge Research Lab MetaMorpheus @metamorpheus.bsky.social Stacy Malaker Cologna Lab Dr. Erin Baker Bleiholder Group Jeff Spraggins Jericha Mill Lauren Fields Gaoyuan Lu gao_lab Zhijun(Andrew) Zhu J. of the American Society for Mass Spectrometry Am Soc for Mass Spec Imaging MS Society MS_Imaging

Exciting opportunity alert for people looking for postdoc positions. Awesome mentor and a lot of exciting research in the Schweppe lab! #TeamMassSpec .

We are looking for a new Assistant, Associate or Full Professor interested in joining the Division of Innate Immunity @UmassChanPII to expand our interests in innate immunity/immunology/cancerimmunology. Check out this Tenure track posting and please apply #innate

We are happy to see CurveCurator and its 'relevance score' highlighted in the bigger picture of omics data analysis. nature.com/articles/s4146….

Original Article: nature.com/articles/s4146…

Check out this massive study led by Gygi Lab member Jonathan Van Vranken and lab alumnus Devin Schweppe to learn how thermal stability measurements and small molecule screening can be used together to tease apart the compounds' direct and indirect effects!

Are you looking to hire top proteomics talent at US HUPO ? Sign up for rare opportunity to pitch your job opportunities to a room full of very talented candidates in proteomics thanks to the ECR Committee

Register to pitch your job opportunities here- shorturl.at/oELX9

Excited to share that our manuscript exploring the analytical merits of the Orbitrap Astral mass spectrometer is out in Nature Biotechnology. Using nDIA, we profile >100 full yeast proteomes per day, or 48 human proteomes per day of ~10,000 proteins. rdcu.be/dxwEi

We quantified 1.498 million thermal stability measurements in cells and crude extracts treated with small molecule therapeutics and tool compounds! We interrogated on- and off-target effects to dissect direct ligand binding and indirect effects.biorxiv.org/content/10.110…

Thanks Nature Reviews Drug Discovery sarah crunkhorn for highlighting our research on the new TMT-ABPP method for reactive cysteine profiling! nature.com/articles/d4157…

Check out our Gygi Lab Ka Yang latest work on activity-based proteome profiling with TMT! Proteome-wide profiling with minimal input enables high throughput characterization of reactive cysteinome to uncover exciting protein-ligand interactions.

My first Gygi Lab paper is out in Analytical Chemistry! Under the mentorship of postdoc Qing Yu I profiled electrophilic compounds’ effects on the proteome at >8k protein depth. The new Ascend takes 30% less time, improves quant, reveals relevant scarce proteins.

pubs.acs.org/doi/10.1021/ac…

Great pleasure to present our progress (Gygi Lab) in developing new TMT-ABPP method for high-throughput chemoproteomic and covalent drug discovery at #ASMS 2023 . Hope to see a #chemoproteomic session in future #ASMS meeting!

If you’re at #ASMS2023 , be sure to catch my talk on combining the ⁦HMSBioPlex⁩ network with AlphaFold! ⁦Gygi Lab⁩

If you’re hoping to catch ⁦Qing Yu⁩ giving his talk, he’s starting right now! If you miss hearing him live, be sure to watch him online later…. ⁦Gygi Lab⁩ #ASMS2023