Brain cell atlas and connectomics identify over 25 types of projections neurons distributed in 11 sublayers in the mouse primary motor cortex upper limb area. Great ressource and new tools from the BRAIN Initiative Cell Census Network #BICCN
biorxiv.org/content/10.110…

It’s a great pleasure to work with such an amazingly collaborative group of neuroscientists, computational and molecular biologists in the BRAIN Initiative Cell Census Network. This is just the first fruit of the BICCN effort. biorxiv.org/content/10.110…

So excited that our work is published in Science today! 📣We profiled regulatory elements from 1.1 million cells across 42 distinct human brain regions🧠, and associated relevant cell types to 19 common neuropsychiatric disorders. Science Magazine #BICCN doi.org/10.1126/scienc…

Understanding which features of brain cell organization are specific to humans, versus nonhuman primates, was a key goal of the #BICCN project.

A Science study used comparative single nucleus transcriptomics to explore this. scim.ag/4Ho

To understand the brain, we must first understand its parts — the cells. Together with dozens of #BICCN -supported teams, we're cataloging cell types in the brain and building the most detailed map of the motor cortex ever. #studyBRAIN #BrainWeek

'[T]he scope and depth of these studies from the #BICCN demonstrate the potential of this type of large cooperative initiative to generate this fundamental knowledge of the human brain,' write the authors of a new #SciencePerspective . scim.ag/4Cj

In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail.

The results uncover the genetic organization of the human brain. scim.ag/4ro

What are the cells that make up our brains? Our researchers together with #BICCN -supported teams released the most comprehensive map of any part of the mammalian brain ever. #OpenScienceWeek

Read: alleninstitute.org/what-we-do/bra…

Examine multimodal data from thousands of cells across 3 mammalian species with the Cell Type Knowledge Explorer, an #openscience resource developed with #BICCN and supported by USBrainAlliance.

#OpenScienceChat #OpenScienceWeek #neuroscience

#ICYMI : In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers presented an atlas of the human and nonhuman primate brain in unprecedented detail.

The results uncover the genetic organization of the human brain. scim.ag/5mu #BICCN

.Allen Institute Examine multimodal data from thousands of #cells across 3 mammalian species with the Cell Type Knowledge Explorer, an #openscience resource developed with #BICCN and supported by USBrainAlliance. #Sfn22
#neuroscience #brain #maps

From SFN nanosynposium today, MERFISH is becoming the dominant spatial technology to chart the cell types in brain for the cell census consortium (BICCN). So excited for Vizgen to be involved in this important scientific endeavor! Vizgen #MERSCOPE

In 21 papers across Science, Science Advances, and Science Translational Medicine, the #BICCN consortium presents an atlas of the human and nonhuman primate brain in unprecedented detail.

The results uncover the genetic organization of the human brain. scim.ag/4u6 (THREAD 🧵)

In Science Advances, Deputy Editor Takaki Komiyama highlights the first large-scale effort to characterize the fine cellular architecture of the primate brain using cutting-edge single cell profiling techniques. #BICCN scim.ag/4ui

A Science study—which involved assessing brain cell type variation across 75 adult humans undergoing epilepsy and tumor surgeries—shows how brain cells vary across individuals.

This provides a baseline for cell typing in health and disease. #BICCN scim.ag/4ud

The core work to build the atlas is represented by three Science studies in the package. These groups’ insights created the first draft of the human brain cell map. #BICCN

📄: scim.ag/4u7
📄: scim.ag/4u8
📄: scim.ag/4u9

The #BICCN package features work exploring how the complex arrangement of cells in our brains is first established, including this Science study that uncovered cell states in human brains during the first trimester. scim.ag/4uf

New in Science Magazine, Nowakowski_Lab and colleagues use #SingleCell RNA sequencing and spatial transcriptomics to show that thalamic nuclei are made up of a mosaic of different cell types: neurosurgery.ucsf.edu/news/brain-cel…
science.org/doi/10.1126/sc…
#studyBRAIN #BICCN UCSF Broad Stem Cell New York Stem Cell Foundation Research Institute

Reading the epigenomes of 100k+ brain cells as part of #BICCN -remarkable work by students @Hanq_liu, Jingtian Zhou and postdocs Zhuzhu Zhang, Wei Tien and all our amazing #BICCN collaborators nature.com/articles/s4158…
nature.com/articles/s4158… nature.com/articles/s4158…

Part of an ambitious effort to comprehensively map all cells in the brain using transcriptomics, scientists at the #BICCN have discovered a new cell type in the cerebellum, a region of the brain that controls movement. #studyBRAIN broad.io/studyBRAIN