Happy #FluorescenceFriday ! Excited for these beautiful DRGs stained by our own Rachel Davis!
DRG cultures stained for CGRP (Pink), Neurofilament (GFP), and DAPI.
'New promise for migraine patients unable to recover from CGRP-targeted therapy'.
#neurology #headache #migraine #cephalalgia
doi.org/10.1177/033310…
Has anyone with #MEcfs #LongCovid #Fibromyalgia etc taken CGRP antagonists like Rimegepant?
نون در غربت You can increase topiramate dose up to 100mg daily. Then try propranolol or amitriptyline/nortriptyline. If no response, you may want to consider CGRP mabs ( Emaglity, Ajovy, Aimovig)
oracling at the f*cking edges of the apocalypse david schwertfeger Isabel Ramirez-Burnett RemissionBiome MECFS/LongCovid Self-Experiment Afaik Ubrelvy and Rimegepant are *CGRP* (Calcitonin gene-related peptide) inhibitors, rather than *GCRP* (G-protein coupled receptor) inhibitors...
#TheAcidTest #TheAcidTest
Just had the weirdest experience. Started on a new med Rimegepant yesterday. Day after 1st dose + some Sx very improved.
Did the lancet, squeezed like usual, got horror-movie long-distance spurt 🙈
Result: T1 (fasting 11 hours): Lactate 0.8
WTF?
Great to be at Univ Michigan this week for the CDI-MOD meeting. Fun to see colleagues like Durga Singer and Stéphanie Eid, PhD and to share our work on adipose CGRP, funded by P&F from Mich MDRC and OSU DMRC.
Dr Naomi Harvey (PhD not MD) #WearAMask #TheAcidTest It's a new one I think, blocks CGRP receptors. I didn't expect it to have any impact on lactate... just another data point for #theacidtest !
Allison Wallis ♿ i haven't had adverse mast cell-related reactions to any of the above, and no side effects at all with the CGRP antagonists.
for me the Vyepti has been the best; it's improved my musculoskeletal chronic pain too
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