Novi Tham(@slumberbell) 's Twitter Profile Photo

use in and

In this month’s issue of , analysis of trial shows:

♥️ 4 out of 5 px were treated with
♥️ use wasn't linked to or
♥️Benefits of remained consistent regardless of
➡️➡️…

#BetaBlocker use in #HFpEF and #HFmrEF❓

In this month’s issue of #JACCHF, analysis of #DELIVER trial shows:

♥️ 4 out of 5 px were treated with #BB
♥️#BB use wasn't linked to #worseningHF or #CVdeath 
♥️Benefits of #Dapagliflozin remained consistent regardless of #BB
➡️➡️…
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Ravi J. Shah(@theravishah) 's Twitter Profile Photo

Excellent review on genetic testing in by Amy R. Kontorovich, MD, PhD
jacc.org/doi/10.1016/j.…

🫀inherited dz is a common cause of DCM
🫀truncating Titan mutations are most common
🫀 Lamin mutations have 100% penetrance
🫀post-mortem genetic testing is possible

Excellent review on genetic testing in #HF by @GeneticHeartDoc #JACCHF #CVgenetics
jacc.org/doi/10.1016/j.…

🫀inherited dz is a common cause of DCM
🫀truncating Titan mutations are most common
🫀 Lamin mutations have 100% penetrance
🫀post-mortem genetic testing is possible
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The Heart(@ZHeart11768530) 's Twitter Profile Photo

🔴 The BAN-ADHF Score predicts low diuretic efficiency, increased length of stay, and higher symptom burden in patients hospitalized with .

✅Can this tool inform initial diuretic dose to improve decongestion and outcomes? bit.ly/4afbwPy

🔴 The BAN-ADHF Score predicts low diuretic efficiency, increased length of stay, and higher symptom burden in patients hospitalized with #ADHF. 

✅Can this tool inform initial diuretic dose to improve decongestion and outcomes? bit.ly/4afbwPy

#JACCHF #HeartFailure
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Novi Tham(@slumberbell) 's Twitter Profile Photo

Is beneficial for with HTN❓

✔️Equally effective for symptomatic with/without HTN
✔️ Similar improvement on LVOT gradient, NYHA FC, peak VO2, QOL, NTproBNP, &echocardiography

Read more🖇️: jacc.org/doi/10.1016/j.…

Is #Mavacamten beneficial for #OHCM with HTN❓

✔️Equally effective for symptomatic #OHCM with/without HTN
✔️ Similar improvement on LVOT gradient, NYHA FC, peak VO2, QOL, NTproBNP, &echocardiography

Read more🖇️: jacc.org/doi/10.1016/j.… #JACCHF #EXPLORERHCM
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Michael H. Beasley, MD(@MHBeasleyMD) 's Twitter Profile Photo

👉In HFpEF, IGFBP-7 is a/w morbidity and mortality. A similar finding was found in HFrEF.
👉Dapagliflozin did not result in a reduction in IGFBP-7 levels in DAPA-HF.
👉Mechanism of benefit for SGLT-2 inhibitors remains elusive...
JACC Journals
📎jacc.org/doi/10.1016/j.…

👉In HFpEF, IGFBP-7 is a/w morbidity and mortality.  A similar finding was found in HFrEF.
👉Dapagliflozin did not result in a reduction in IGFBP-7 levels in DAPA-HF.
👉Mechanism of benefit for SGLT-2 inhibitors remains elusive...
@JACCJournals #JACCHF 
📎jacc.org/doi/10.1016/j.…
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Subodh Verma(@SubodhVermaMD) 's Twitter Profile Photo

📰Just published in JACC Journals: 'Design & baseline characteristics of STEP-HFpEF program evaluating semaglutide in patients with obesity HFpEF phenotype'
Mikhail Kosiborod
jacc.org/doi/abs/10.101…

📰Just published in #JACCHF @JACCJournals: 'Design & baseline characteristics of STEP-HFpEF program evaluating semaglutide in patients with obesity HFpEF phenotype'
@MkosiborodMD #CardioTwitter #Cardiology 
jacc.org/doi/abs/10.101…
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Eiran Gorodeski, MD, MPH(@EiranGorodeski) 's Twitter Profile Photo

I've always been bothered by arbitrary cutoffs LVEF by which we make decisions for GDMT. Shown here is 'Current HF Classification and the New Proposed Conceptualization of LVEF.' jacc.org/doi/10.1016/j.…

I've always been bothered by arbitrary cutoffs LVEF by which we make decisions for GDMT. Shown here is 'Current HF Classification and the New Proposed Conceptualization of LVEF.' #JACCHF jacc.org/doi/10.1016/j.…
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Ankeet S. Bhatt, MD, MBA(@ankeetbhatt) 's Twitter Profile Photo

Pleased to share our European Society of Cardiology of initiation & discontinuation patterns for now out JACC Journals @JACCHF
🎯 >1 in 10 discontinue ARNI early
🎯 Subsequent ACEi/ARB Rx in <50% when discontinuing ARNI (& at lower doses)
jacc.org/doi/epdf/10.10…

Pleased to share our @escardio #HFA2023 #simpub of initiation & discontinuation patterns for #sacval now out @JACCJournals @JACCHF
🎯 >1 in 10 discontinue ARNI early
🎯 Subsequent ACEi/ARB Rx in <50% when discontinuing ARNI (& at lower doses) 
jacc.org/doi/epdf/10.10…
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Aditi Nayak(@AditiNayakMD) 's Twitter Profile Photo

🔥JACC Journals our commentary on WHY, WHEN and HOW to use in . Mandeep R. Mehra, MBBS, MSc, FRCP (London) Akshay Desai
jacc.org/doi/10.1016/j.…

WHY?
Advanced is defined by the transition from Neurohormonal➡️invasive LAPLACE therapeutics, for which is the only scalable therapy
1/3

🔥@JACCJournals #JACCHF our commentary on WHY, WHEN and HOW to use #LVAD in #HF. @MRMehraMD @akshaydesaimd 
jacc.org/doi/10.1016/j.…

WHY? 
Advanced #HF is defined by the transition from Neurohormonal➡️invasive LAPLACE therapeutics, for which #LVAD is the only scalable therapy
1/3
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Jacopo Imberti(@JacopoImberti) 's Twitter Profile Photo

📚JACC STATE-OF-THE-ART REVIEW

Arrhythmia induced
🔹Noxae acting on a vulnerable substrate
🔹Usually reversible, but may recur
🔹Multiple mechanisms involved👇

🖇️tinyurl.com/32873d3v

Xander Wehrens Joshua Keefe JACC Journals

📚JACC STATE-OF-THE-ART REVIEW

Arrhythmia induced #cardiomyopathy
🔹Noxae acting on a vulnerable substrate
🔹Usually reversible, but may recur
🔹Multiple mechanisms involved👇

🖇️tinyurl.com/32873d3v

@XWehrens @joshua_A_keefe @JACCJournals 
#Epeeps #JACCHF #JACCEP
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