Yesterday morning, we held an interesting #JournalClub session, focusing on AAs IV infusion for #renal #protection

In 1973, Abel et al (NEJM) introduced the potential benefits of AAs on survival, in #AKI pts

Can’t wait for #PROTECTIONtrial results ( #CCR24 - Belfast, June 12th)

Thrilled about this new talk from Professor Giovanni Landoni, MD

Could amino acids help preventing #AKI ?

Stay tuned for the #PROTECTIONtrial results (coming soon)

4 patients randomized into the #PROTECTIONtrial in 12 minutes in 3 centers! you are ROCK!

The story of amino acids and AKI began in the 70s!

The result of #PROTectiontrial is much awaited!!
#ISICEM24 ISICEM Giovanni Landoni, MD San Raffaele Anesthesia and Intensive Care

We are happy to annouce that ours Giacomo Monti, Martina Baiardo Redaelli, and Giovanni Landoni, MD will present the results of the #PROTECTIONtrial and #NAVIGATEtrial in Belfast at Critical Care Reviews

criticalcarereviews.com/meetings/ccr24…

#CCR24

San Raffaele Anesthesia and Intensive Care has two actively recruiting multicenter randomized trials in cardiac surgery patients.
#PROTectionTrial #ANHtrial

Your participation will further improve the quality of the evidence.

Let's make evidence together

#Anestwitter #CardioTwitter #FOAMcc

🎉Congratulations to this brilliant colleague of mine!!
So blessed to be part of the team

🎙Stay tuned for the results of #PROTECTIONtrial this June Critical Care Reviews in Belfast

#CCR24

Prof. Giovanni Landoni, MD showed preliminary evidence about IV amino acid administration in reduction of AKI

#PROTectionTrial results will be available soon!✅

🫀3500 #Cardiac #surgery pts
💉AAs vs placebo
🌍Over 20 centres
#International trial

#FOAMed #FOAMcc
San Raffaele Anesthesia and Intensive Care

4/5

#PROTectionTrial

📨Please DM Giovanni Landoni, MD/San Raffaele Anesthesia and Intensive Care
 
🤔Can infusion of amino acids reduce #AKI in cardiac surgery patients?
 
🌍17 active centers in 2 countries
🎯1500/3500 pts to be recruited
 
🔗clinicaltrials.gov/ct2/show/NCT03…
#CardioTwitter #FOAMcc

Honoured to present #PROTECTIONtrial Critical Care Reviews

💉Is IV amino acids infusion effective in preventing #AKI in #cardiacsurgery 🫀 patients?

💉Amino acids are studied for several purposes, including nutrition, thermogenesis, and shivering.

Probably, the most promising field could be #AKI , slightly neglected after 1973.

📣Stay tuned for the #PROTECTIONtrial results in Belfast #CCR24
🔗 pubmed.ncbi.nlm.nih.gov/36038001/

📝The methodological paper of #PROTectionTrial was published

🤔Is amino acid infusion effective for reducing AKI in pts undergoing cardiac surgery?

🌏New participating centers are always welcomed.

Please contact San Raffaele Anesthesia and Intensive Care Giovanni Landoni, MD

🔗sciencedirect.com/science/articl…

The article is now on pubmed pubmed.ncbi.nlm.nih.gov/36038001/

Last week we randomized a record of 34 patients (7 each working day)

#PROTECTIONtrial will be completed within 1 year and will inform us on the effect of a continuous infusion of aminoacids on perioperative #AKI

1/8

Let's make evidence together 🌎🤝

We need your help with our 7 ongoing mRCTs in 4 different settings
 
🔸Cardiac surgery
#PROTectionTrial
#ANHtrial
 
🔸Non-cardiac surgery
#PRINCEtrial
#PRESStrial
 
🔸ICU
#PPISEPSIStrial
#PIONEERtrial
 
🔸General ward
#NAVIGATEtrial

Nobuto Nakanishi (中西信人) 色んな効果が期待されてますよね。
私のいる施設 San Raffaele Anesthesia and Intensive Care ではアミノ酸の持続静注で心外術後AKIが減るか、という多施設RCTが進行中です。
#PROTectionTrial

📌Did you know that IV amino acids… result in afferent arteriolar dilation?

⬇️tubular [NaCl] ➡️ EGF/PG release from macula densa ➡️ impair voltage-dependent Ca++ channels in smooth muscle ➡️ afferent arteriolar vasodilatation

🔗 pubmed.ncbi.nlm.nih.gov/8258943/

#PROTectionTrial #AKI

Joel M. Topf, MD FACP Syed Shahrul Naz 3500 patients randomized to Intravenous amino acid therapy for kidney protection in cardiac surgery

findings to be published in 2024

let’s see

#Protectiontrial

pubmed.ncbi.nlm.nih.gov/36038001/

Nicole Hunfeld Filippo D'Amico it must be taken into account in order not to administer >100g per die of amino acids

the #PROTECTIONtrial was conducted in cardiac surgery, where early trophic enteral nutrition is not routinely administered