📍Digoxin binds to extracellular face of Na+/K+ ATPase on myocardial fibres. Inhibition of enzyme: progressive accumulation of more Na+ intracellularly.

📍For 3Na+/Ca2+ antiporter: transmembrane gradient for Na+ is reduced. More calcium is retained intracellularly; more loading…

Cation antiporter.

“Antiporter-like protein subunits of the respiratory chain Complex I”

They won.

doi.org/10.7554/eLife.…
Our paper describing the first structure of the MRP antiporter, a dimer with 100 TM helices in total, is out now in eLife - the journal. Strikingly, helices in sodium-translocating domains (cyan) are highly tilted vs those in proton-translocating subunits (green).

Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP | eLife

doi.org/10.7554/eLife.…

#CryoEM #antiporter #MembraneProteins

Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na+/H+ antiporter | Nat Plants

doi.org/10.1038/s41477…

#CryoEM #antiporter #MembraneProteins

Check our new article on coupling mechanism of respiratory complex I. #Mitochondria
Long-range electron proton coupling in respiratory complex I – insights from molecular simulations of the quinone chamber and antiporter-like subunits | ChemRxiv - go.shr.lc/3RBexSD

Congratulations to Jiangyan @feng_jf8 for this interesting work on how NarK, a nitrate/nitrite antiporter exchanges substrates. This study present one of the few detailed computational investigations of an antiporter in literature. @ChBE_Illinois Diwakar Shukla Transporters and Solute carriers

How ATP is used to package neurotransmitters into vesicles (indirectly):

ATP is used to pump hydrogen ions into vesicles so there’s a high concentration of them inside.

The concentration gradient of H+ is used to transport neurotransmitters in via an antiporter.

new release2

7P9V: Cryo-EM structure of System XC-
7P9U: Cryo-EM structure of System XC- in complex with glutamate

Newstead lab.

'Molecular basis for redox control by the human cystine/glutamate antiporter System XC-'

Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance | Nat Plants

doi.org/10.1038/s41477…

#CryoEM #antiporter #MembraneProteins

Review chapter on 'General principles of #transporter function' with Fiona Naughton – alternating access, cycles, energy transduction, inverted repeat symmetries, gated pores, and a unified symporter/antiporter/uniporter model: arxiv.org/abs/1912.06275

Our last seminar before the summer is by our PhD student ⁦Tom QiTong Lin⁩ on EF-hands in the LETM1 antiporter. 3pm in MSB 384 or by zoom.

Who says nature doesn't have a backup plan?
Alternative proton-binding site and long-distance coupling in Escherichia coli sodium–proton antiporter NhaA pnas.org/content/early/…

Our paper on F exporters is finally out🎉🎉🎉Great work by Kira Kira Mills , showing how proton-coupled Fluoride (but not HF) transport happens in the CLCF antiporter pubs.acs.org/doi/10.1021/ac… #jcim #compchem

Modification of activity of the thylakoid H+/K+ antiporter KEA3 disturbs ∆pH-dependent regulation of photosynthesis #Membranes #Bioenergetics #Photosyntheses #PlantBiology doi.org/10.1104/pp.19.…

Check our new article in Chemical Science

Horizontal proton transfer across the antiporter-like subunits in mitochondrial respiratory complex I

Multiscale simulation work by Oleksii Zdorevskyi, Amina and Jonathan Lasham

pubs.rsc.org/en/content/art…

29) Did you mark C?
In fact, #GLP -1 agonists reduce phosphorylation of renal cortical Na+/H+ exchanger isotope 3 (NHE3) antiporter, which correlates with NHE3 reduced transport activity in the proximal tubule and resultant natriuresis.
🔓journals.physiology.org/doi/full/10.11…

Antiporter aficionados: relaxing w Klaus Fendler's group at Oberurseler Brauhaus after my talk @ Max Planck Inst Frankfurt

We are happy to report our joint structural-simulation work on sodium translocating Mrp antiporter. Nature Communications
nature.com/articles/s4146…
High resolution structure (2.2 Å) solved by Yongchan Lee and MD simulations by Outi Haapanen