We now have vaccines that can be used to target #malaria parasites (RTS,S and R21) , but these can only help reduce disease burden and are by no means a magic bullet. Why is it so hard to make really effective vaccines against malaria? #infectneXt (a thread 1/5)

Mattea Scheiner is characterizing a protease that Plasmodium need to leave the liver at the end of this infection stage. She works in my group Alyssa Ingmundson and is part of @SPP2225. #infectneXt

It's #WorldMalariaDay today: April 25! #Malaria researcher Anna Bachmann from Bernhard Nocht Institute for Tropical Medicine talked to her Ghanaian colleague Oumou Maiga-Ascofaré from Kumasi Centre for Collaborative Research (KCCR) about her motivation, role models and future challenges in malaria control. Anna Bachmann Oumou Maiga-Ascofare

Plasmodium is notorious for growing in the blood and causing #malaria , but the liver stage of growth is essential for the parasites to establish infection. One Plasmodium sporozoite can take over a host hepatocyte and generate thousands of progeny. #infectneXt

Today is the International day of laboratory animals #LabAnimalDay :
Infect-Net member Maren von Köckritz-Blickwede Research group Infection Biochemistry from #TiHo Hannover conducts research to further reduce the use of animal experiments where possible. #LabAnimalDay

In honor of #WorldMalariaDay coming up later this week (April 25!) Anna Bachmann Anna Bachmann, Michaela Petter Michaela Petter and I Alyssa Ingmundson will being taking over this bit of your feed and sharing info about #malaria

Malaria cases and the deaths caused by #malaria dropped between the years 2000 and 2015, but in recent years, the progress has slowed. A trend you can see from the World Health Organization (WHO) World Malaria Report who.int/publications/i… (CC BY-NC-SA 3.0 IGO). #infectneXt

Today #infectneXt talks about #malaria . One of the pioneers for #malaria Vaccine was the #biologist Ruth S. Nussenzweig (1928–2018), who discovered the key component of the recently endorsed vaccines: the circumsporozoite protein (CSP) of Plasmodium falciparum. #WomeninScience

You want to seal the #LeakyPipeline in #GlobalHealth ? German Alliance for Global Health Research offers an intensive #workshop program to establish #genderquity in Global Health. 🌍👇🏽
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#WorldMalariaDay2024 : more impressions from our spokeswoman Prof. Dr. Gabriele Pradel and her team at the #MIM2024 conference in Kigali, Ruanda. #EndMalaria #MalariaDay

Unser Interview mit Oumou Maiga-Ascofaré Oumou Maiga-Ascofare zum #WeltMalariaTag finden Sie auch auf Deutsch auf unserer Homepage: infectnet.org/web/blog-post.…
Anna Bachmann Bernhard Nocht Institute for Tropical Medicine

📢Infect-Net also joins this statement of the German societies in #lifescience around the GBM e.V. and supports the demands for the amendment of the #WissZeitVG . For attractive and sustainable careers in science! 👩🏿‍🔬👩🏾‍🎓👩🏽‍⚕️👩🏻‍🏫👩🏼‍💻

Ruth S. Nussenzweig also pioneered the use of radiation-attenuated parasites for #MalariaVaccination , an idea now being pursued by Sanaria Inc.. In addition, genetically and chemically attenuated parasites are also currently being evaluated. doi.org/10.3389/fimmu.…

In the context of #WorldMalariaDay our spokeswoman and parasitologist Gabriele Pradel is attending the #MIM2024 conference in Ruanda this week.

In 2013, Ruth Nussenzweig told the The New York Times that she encountered obstacles as a #WomaninScience . ' It was just not accepted that women could achieve something more,' she said. She added: 'It’s a hard career, but if you persist, it gives a lot of satisfaction.' #changethistogether

Recently Sanaria Inc.. reported that their new PfSPZ-LARC2 vaccine developed with the @seattlechildrento prevent malaria infection is ready for human testing. Two gene deletions render this vaccine strain incapable of causing symptomatic blood infections. doi.org/10.1038/s44321…

The disease burden is unevenly distributed. The people most at risk for severe malaria are young children (under the age of 5) and pregnant women. And in 2022 over half of the deaths caused by #malaria were in four African countries.

📢Auch Infect-Net schließt sich dieser Stellungnahme der #Fachgesellschaften um die GBM e.V. an und stellt sich hinter die Forderungen zur Novelle des #WissZeitVG . 👩🏿‍🔬👩🏽‍🎓👩🏽‍⚕️👩🏻‍💻👩🏼‍🏫

You can find the DZIF - Deutsches Zentrum für Infektionsforschung interview with Oumou Maiga-Ascofare here: dzif.de/en/good-see-bo…