#UBuffalo findings reveal #RNAEditing may play a larger role in human biology & in the development of human disease than has been understood.

» Read about the Communications Biology study, which provides evidence for a more nuanced understanding of molecular biology: buff.ly/3Vo10B6

Enrico Bortoletto at #DiBioRetreat2024 , shares his works on #RNA editing and #development and #immunological processes.
#RNA editing
#immunity
#mollusca

Patho-DBiT
Spatial #RNAWorld on FFPE section👹

Now tissues can be mapped by RNA variants or non-coding RNAs🤯

Whole transcriptome sequencing covers
mRNA
LincRNA
microRNA
sn/snoRNA
#AlternativeSplicing 105 events/85 genes/spot🤓
#RNAEditing
RNA #SingleNucleotideVariation

$KRRO seems to be developing a once-every-2-weeks intravenously infused #RNAediting oligo for #AATD *;

how do they want to compete with $WVE's subQ oligo with similar, if not less frequent admin and most likely better safety/tolerability (-->LNP)?

*shown here is the activity in

We are excited to welcome Rachel Meyers, PhD, to the Company’s Board of Directors as we advance our portfolio of RNA editing programs.

Read more in our press release: bitly.ws/33D4B

#RNAediting #KorroBio $KRRO

💪 $PRQR ON TRACK for CTA (as guided) by ye24/25 for both NTCP in cholestatic and B4GALT1 for cardiovascular disease.

VERY promising NHP data and improved potencies of editing oligos.

Curious: havent revealed delivery modality --> $LLY?

#RNAediting $WVE $KRRO

Had a wonderful day visiting the Case Western Dept of Genetics and chatting science with all the great RNA and neuroscientists here - also got to capture this #RNAediting relic

A great visit with Jen Heemstra and the Heemstra Lab. Her passion for “creating a healthier academic culture for the next generation of researchers,” is an inspiring and noble mission. #HeemstraLab #MOBIO #MentorFirst #RNAediting

𝐓𝐡𝐞 𝐟𝐢𝐫𝐬𝐭 𝐑𝐍𝐀 𝐞𝐱𝐨𝐧 𝐞𝐝𝐢𝐭𝐨𝐫 𝐢𝐬 𝐡𝐞𝐚𝐝𝐞𝐝 𝐟𝐨𝐫 𝐭𝐡𝐞 𝐜𝐥𝐢𝐧𝐢𝐜, 𝐚𝐬 𝐚 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐟𝐨𝐫 𝐒𝐭𝐚𝐫𝐠𝐚𝐫𝐝𝐭 𝐝𝐢𝐬𝐞𝐚𝐬𝐞

Read it here: shorturl.at/besB3

#crisprmedicine news #crisprmedicine #rnaediting #blindness

We had an incredible time ringing the Nasdaq closing bell and celebrating our recent achievements, including bringing the first-ever #RNAediting therapeutic candidate into clinical development. Thanks for hosting us Nasdaq Exchange! $WVE

Today we have announced new preclinical data for our Axiomer™ #RNAediting technology platform, including the 1st preclinical proof of concept data for our AX-0810 pipeline program for cholestatic diseases targeting NTCP.
Read the latest PR here: bit.ly/3JV2pbL
$PRQR

Reviewing the landscape of #RNAediting & #immunity !
Our review in Cell Trends Genetics delves into ADAR1's role in cellular defense. Could this knowledge unlock new avenues for inflammatory & autoimmune disease treatment?
Dive in: shorturl.at/imUXY
#ScienceReview

Join us TMRW (Feb. 8, 1–3pm CT) as Paloma Giangrande, PhD Paloma Giangrande Wave Life Sciences dicusses #RNAediting as therapeutic modality. She'll speak at our expert-led session on 'Novel Approaches for Treating #GeneticDiseases .' Discuss live & see on demand asgct.org/asgct-events/f…

New data on KRRO-110 in genetic models of Alpha-1 Antitrypsin Deficiency ( #AATD ) presented today at the American Thoracic Society (ATS) International Conference in San Diego.

Read the press release for more details: ir.korrobio.com/news-releases/…

#ATS2024 #RNAediting #KorroBio $KRRO

On our way to #ASGCT2024 ! Look out for poster times and locations from our group in the following week! #neuro #CRISPR #epigenetics #RNAediting ASGCT #FinkLab #HalmaiLab

$PRQR considering that 2'-O-methylation opposite the target A renders EON inactive and DNA (2'-deoxy) is considered a stabilizing modification in this context...

...ProQR basically owns synthetic oligo-mediated #RNAediting in EPO countries.

$WVE $KRRO $LLY

$PRQR $LLY #RNAediting abstract on subQ-administered GalNAc editing oligo pharmacology at ASGCT...

VERY PROMISING, commercially relevant path (target is enzyme involved in metabolic disease):

Drs Julius Lukeš, Dave Speijer Alena Zikova Juan Alfonzo, Hassan Hashimi & Mark Field discuss #trypanosomes as an experimental model for molecular & cell biology. #RNAediting #GeneticCode #tRNA #Endocytosis #GPIanchor #Glycosome #AlternativeOxidase

authors.elsevier.com/a/1hiha5Eb1xFU…