Diagnosing MSA-C is challenging. We solved this using MRI. In a 20 year study we show that ~ 0.8 mm/year atrophy of pons and middle cerebellar peduncle diameter is diagnostic. True throughout the disease course. ⁦@MSACoalition⁩ ⁦National Ataxia Foundation⁩
doi.org/10.1093/brainc…

1/n: There are some academic papers that are so brilliantly and so accessibly written and so universal in scope that they transcend disciplines and stand as timeless testaments to both great thinking and great writing. Here's a short personal selection:

Ever wondered how closely #fMRI brain networks reflect a neural underpinning❓

We address this using simultaneous fMRI & widefield Ca²⁺ imaging in mice, and the answer is… complicated!

👉🧵[1/n]

Jointly supervised by Evelyn & Luiz Pessoa

nature.com/articles/s4146…

We determined the top 4 FC gradients.

We discovered G-1's remarkable consistency across BOLD and Ca²⁺ conditions (r = 0.97), lending fundamental support for its neural origin.

➡️ at a very coarse level, fMRI & Ca²⁺ signals capture the same underlying organization.

🧵[12/n]

Patients with sagging brain syndrome due to loss of spinal CSF often present with compulsive repetitive flexion (at the waist) with breath holding (CoRFBiS). We believe this is pathognomic of the syndrome. ⁦Schmahmann Lab⁩ ⁦spinalCSFleak⁩ #FTD neurology.org/doi/10.1212/CP…

Ever wondered if there's more to clinical assessment of movement disorders than our good ol' scores capture?
🧠New research alert!

Harvard Medical School honors
Martin A. Samuels, MD, MACP, FAAN, FANA, FRCP, DSci (hon)
Miriam Sydney Joseph Distinguished
Professor of Neurology
Harvard Medical School
Founding Chair, Department of Neurology
Brigham and Women's Neurology Brigham and Women's Hospital
His legacy lives on in those he taught

'DMN combines episodic memory, language, and semantic memory processes to generate an ongoing internal narrative and subjective continuity of internal mental thoughts', see new article from our close collaborator Dr. Vinod Menon Stanford Cognitive & Systems Neuroscience Lab: doi.org/10.1016/j.neur…

We’ve identified the somato-cognitive action network (SCAN), a newly recognized network within human primary motor cortex that disrupts the famous—but incorrect—motor homunculus, and has strong connections to high-level control networks. Now out in nature nature.com/articles/s4158…

Here are the areas of hypometabolism on one of my patients. What are the symptoms? #endalz #getanFDG

I get this question all the time, 'how will my atypical parkinsonism progess.' This is a a new paper in Brain Looks to me like it is dogma when docs flippantly say 'you have 5 years.' Great read by Street and Rowe and comments on clinical trials.
academic.oup.com/brain/advance-…

One contrast per day. characters suffering from mental pain versus physical pain. Task designed from Rebecca Saxe lab. All IBC contrasts available in search.kg.ebrains.eu and neurovault.org/collections/66…

Lecanemab: turning point, or status quo? An ethics perspective in Brain
academic.oup.com/brain/advance-…
to Hardy & Cath Mummery🍊
I cite Alberto J Espay Nicolas Villain Lon S. Schneider, MD Seb Walsh & argue 'belief in the amyloid hypothesis continues to drive priority setting in AD research'

🤩Beautiful layer and lobule segmentations of the cerebellum in BigBrain. rdcu.be/c76ZH🤩

Please mark your calendars. Spectacular day of science and tribute to Professor Deepak N. Pandya, great neuroanatomist and brain scientist of our era. ⁦American Neuropsychiatric Association (ANPA)⁩ ⁦Society for Neuroscience (SfN)⁩ ⁦American Academy of Neurology⁩ ⁦MGH Martinos Center⁩ ⁦⁦⁦Mass General Research Institute⁩ ⁦National Ataxia Foundation⁩

I'm speechless.

Not peer-reviewed yet but a submitted paper.

The 'presented images' were shown to a group of humans. The 'reconstructed images' were the result of an fMRI output to Stable Diffusion.

In other words, #stablediffusion literally read people's minds.

Source 👇

I'm thrilled that THINGS-data is now online! We provide 3 massive datasets of fMRI, MEG, & behavior in response to up to 1854 objects and >22k images. We hope this will allow studying objects in vision, memory & language with unique semantic breadth! Link: doi.org/10.25452/figsh…

T2/FLAIR: we see atrophy, high signal, and architectural distortion

Secondary signs include ipsilateral atrophy of the mammillary body and fornix as seen in this case

👇

Geometric constraints on human brain function | #bioRxiv biorxiv.org/content/10.110…

I am a bit late in pointing out the genius of this paper. It is the neurohospitalist #1 paper of the year

Autoimmune Encephalitis Misdiagnosis in Adults

How often have YOU seen examples of pts getting empiric immunosuppression for misdiagnosed AE? /1

ja.ma/3k7ydkf