Reduction of soluble Aβ42 or Aβ40 through solanezumab increased CSF NfL. 'Binding soluble amyloid-β was associated with increased measures of neurodegeneration.'

Biomarker analysis of the DIAN-TU-001 study of dominantly inherited #Alzheimers
JAMA Neurology jamanetwork.com/journals/jaman…

Empowering Historic Breakthroughs.

We are thrilled to announce a $13.5 million gift from the Hugh H. Hoffman estate that will revolutionize ALS research and patient care.

Discover More: go.uchealth.com/3Uk2Ocr

Corticospinal tract hyperintensity is not an infrequent finding in LGI1-Ab #encephalitis and other #autoimmune CNS disorders, and may appear in patients without clinical UMN involvement. Take a look to our study led by Lucia Campetella and French Reference Center for PNS and AE : authors.elsevier.com/a/1iyxz_3myAxv…

Prof Scott Ayton Simon Mead Timothy Daly, PhD Madhav Thambisetty Eric Widera, MD Andrew Lees Robert Howard Jason Cohen radical optimism Lon S. Schneider, MD Seb Walsh Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Nicolas Villain Kasper Planeta Kepp Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD FORTUNE TIME Erin Prater TIME Financial Times Hannah Kuchler CTAD NIH Alzheimer's Association Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Maastricht University Kariem Ezzat Dr Ben Underwood NHS England The Observer Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease neurology.org/doi/10.1212/WN… via Johns Hopkins Bloomberg School of Public Health 's #CalebAlexander et al Results don't look v appetising Feng Xie

Your white coat is a symbol of compassion, a beacon of hope, a shield against suffering.
It is a conduit through which empathy and understanding flow.
Your coat is the weight and privilege you carry as a physician and the weight of the lives of people you touch. Alberto J Espay

Best advice for to-be doctors: listen to your patients with intention and purpose. It is the basis for an accurate diagnosis and compassionate, healing care. UTHealth Houston Dr. Erin Furr Stimming's 7-minute White Coat Ceremony address starts at ~7:27: youtube.com/watch?v=nBo4ol…

Luke Child Dabin, PhD More details about the basis of this criticism can be found here if you're interested: mdpi.com/2079-7737/11/4…

In this data-mining study, antipsychotic use in dementia was linked to all sorts of poor outcomes. But wouldn't these be inflated given the choices for controls: 'non-users using incidence density sampling' and appendicitis and cholecystitis patients?
bmj.com/content/385/bm…

Wrapping #AANAM at the highest level of #FND science. Mark Edwards and Sarah Lidstone translated research findings to the formulation of diagnosis and treatment of patients. A practical and dynamic presentation. 🙏🏻

“Saying autonomic dysfunction is almost meaningless” - David Goldstein, reviewing the increasingly complex Extended Autonomic System at #AANAM

Sjors Scheres The problematic word here is 'always'. It's mechanistically impossible for a process dominated by surface interactions (2ry nucleation & other) to sustain templating via elongation & to 'always' generate the same polymorph. That's why heterogeneity is the norm in plaques. (1/2)

Troriluzole emerges as disease modifying for SCA3 when using a matched natural history cohort. Impressive. If replicated in a controlled trial with matches controls it will be a major win for the ataxia community. Excellent presentation by Melissa Beiner. #AANAM

ALS and spastic parkinsonism can be associated with mutations in the KIF5A gene. Nice clinical-genotype correlative study led by ⁦Mayo Clinic⁩ Jacksonville’s Jaroslaw Dulski, presented at #AANAM

⁦Donald Gilbert⁩ presented an interesting sub analysis of the Phase 2b (D1AMOND) trial of ecopipam in Tourette syndrome. There is novel information when examining the changes in YGTSS, the main endpoint. This study has been a labor of love for Dr. Gilbert. #AANAM

Ulixacaltamide —benefits in essential tremor are enhanced with propranolol. A reminder that inclusive trials (minimizing exclusionary drugs) inform about unknown synergies. Dr. Rich Able presenting this interesting sub analysis on behalf of Praxis. #AANAM

Proof that the rivalry is for the gullible twitter audience only. #AANAM

Sjors Scheres Alberto J Espay Is there anything else you think is 'flawed' in the paper?

To be honest, I think the assertion that a specific protein fibril shape characterizes each of these complex diseases, when the fibrils don't even predict disease and lack causal mechanisms, seems a bit too reductionist.

Psychedelics. This blew my mind. Or “recalibrated” it. #AANAM