A Prospective Randomized Trial of Direct Oral Anticoagulant Therapy with A Fully Magnetically Levitated LVAD: The DOT-HM3 Study | Circulation ahajournals.org/doi/10.1161/CI…
The ISHLT plenary presentation! Ivan Netuka Mandeep R. Mehra, MBBS, MSc, FRCP (London) Peter Ivak Zuzana Tucaniva 😀 colleagues

Big congratulations to inspiring role models and amazing mentors Jennifer Ho and Robert W. Yeh MD! So well deserved!! MGH Cardiology Fellows BIDMC CVI ASCI

High gradient but big AVA?
The gradient wins!
A really interesting paper: Prognosis of Discordant High-Gradient Aortic Stenosis: Trust the Gradient sciencedirect.com/science/articl…

Contemporary American & European Guidelines for the Management of #HeartFailure : JACC Journals #JACCHF Guideline Comparison

jacc.org/doi/10.1016/j.…

A paper in nature presents a comprehensive spatial cell atlas of the developing human heart, which shows how different heart cell types interact and organize into complex cardiac structures that are critical for heart function. go.nature.com/43eWAhY

RNA Therapeutics for the Cardiovascular System ahajournals.org/doi/abs/10.116… Circulation Victor Dzau

Research| With a genome-wide #CRISPR screen in #iPSC , the authors identify the acetyl-lysine reader BRD4 as a regulator of cardiomyocyte differentiation that they subsequently validate in vivo PennCVI Gladstone Institutes UPenn CDB Penn Epigenetics UCSF Cardiology
👉rdcu.be/dzrQm

Excited to share AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in nature
nature.com/articles/s4158…

Proud to be a part of Brigham and Women's Hospital heart transplant program with amazing colleagues and thankful to our patients Mandeep R. Mehra, MBBS, MSc, FRCP (London) Michael Givertz Neal Lakdawala Jon Cunningham Charlotte Andersson, MD PhD Nasrien E. Ibrahim MD, MPH Aki Itoh Jeong Hwan Kim Haider Warraich and others #transplant #heartfailure

Couldn’t agree more! Feel very fortunate to be a part of this group and looking forward to catching up with my friends/colleagues Michael Honigberg, MD, MPP Peter Miller Senthil Selvaraj, MD, MS, MA William Goodyer, MD/PhD Maria C. Basil Paula Chatterjee Jeffrey Ishizuka Naoka Murakami Lachelle Dawn and many others

New manuscript from our group studying DCM-TTNtvs and transcriptional modulators that reverse haploinsufficiency. ahajournals.org/doi/10.1161/CI…

New #JACCHF state-of-the-art review provides a comprehensive approach to the use of invasive hemodynamic assessments in patients supported with LVADs. bit.ly/3O36yge

#LVAD #HeartFailure Filio Billia

Whole-genome sequencing of half-a-million UK Biobank participants medrxiv.org/cgi/content/sh… #medRxiv

A new era of CRISPR-based medicines with single treatments that offer curative potential!

Kudos to ⁦Vertex Pharmaceuticals⁩ and ⁦CRISPR Therapeutics⁩

FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease | FDA fda.gov/news-events/pr…

Only 2 days left for abstracts for #EMBOCardioBiology . Don’t miss it and join us to discuss your discovery with the experts in the fields (cardio, vascular, engineering) at beautiful double helix venue at EMBL!

The 3D structure that powers our heart—myosin—finally unraveled with the help of #alphafold2 and cryo-EM with surprises
nature.com/articles/s4158…
nature.com/articles/s4158…

🔬 Exciting news! Our latest study, published in JACC Journals, investigates an understudied aspect of TTNtv – its impact on skeletal muscle. We report findings indicating an effect of TTNtv beyond the heart. Dive into the full study here: authors.elsevier.com/a/1i85H7tD%7EZ… 🧬

Poster on Genetic Heart Disease | Print and stick on the wall in clinic
Thanks American College of Cardiology
t.ly/LahM_

The new CRISPR-based therapy for sickle cell disease & beta-thal is a win for GWAS.
The target (BCL11A) for the Vertex Pharmaceuticals CRISPR Therapeutics therapy was first prioritized by GWAS of HbF & disease modification, with subsequent molecular characterization of the prioritized gene.
Some…

Excited to learn about impressive and inspiring work by Johannes Backs on CaMKII and HDAC4 behind heart disease. #olsonites Eric N. Olson GuoHuangLab(黄果实验室)@UCSF Dan Quiat Rusty Montgomery Matthew Potthoff McKinsey Lab Brian Black Enzo Porrello David M. Patrick M.D., Ph.D. Glynnis Garry and others #AHA2023