'Effects of sceptical priors on the performance of adaptive clinical trials with binary outcomes'

onlinelibrary.wiley.com/doi/10.1002/ps…

Another beauty led by Anders Granholm Benjamin Skov Kaas-Hansen INCEPT Anders Perner

For more on adaptive trials in critical care, see atsjournals.org/doi/full/10.11…

A step into the future of clinical trials, shaped by the critical care community.

PRACTICALPlatform
REMAP Network EdinUni_TRAITS INCEPT PANTHER trial remap-cap Anders Perner Manu Shankar-Hari Ewan Goligher Eddy Fan Danny McAuley Srinivas Murthy, MD, MHSc

🔗 bit.ly/3UYrMjF

'Effects of duration of follow-up and lag in data collection on the performance of adaptive clinical trials'

Led by Anders Granholm Benjamin Skov Kaas-Hansen INCEPT Anders Perner

Open access: onlinelibrary.wiley.com/doi/10.1002/ps…

Vi søger en #projektkoordinator til INCEPT platformsforsøget
Del gerne og søg, hvis du vil være med til at forbedre behandlingen på ITA og generisk
Rigshospitalet

Sundhedsjobs.dk - Projektkoordinator til INCEPT Intensive Care Platform Trial sundhedsjobs.dk/jobopslag/4600…

INCEPT CRIC

'The Rise of Adaptive Platform Trials in Critical Care'

New ATS Blue Journal led by Ewan Goligher Eddy Fan PRACTICALPlatform w/* REMAP Network EdinUni_TRAITS INCEPT PANTHER trial Anders Perner Manu Shankar-Hari
Srinivas Murthy, MD, MHSc Danny McAuley Sarina Sahetya

🔓: doi.org/10.1164/rccm.2…

*tagged my best

Interested in conditional average treatment effects (ie, CATE) to assess HTE in a Bayesian causal framework?

Chk out (esp our supp & git page): nature.com/articles/s4159…

Co-led by Bryan Blette & Anders Granholm, w/ Manu Shankar-Hari Anders Perner Fan Li & some of the INCEPT team.

Massive team effort from good colleagues in 🇩🇰🇮🇳🇦🇺🇧🇻🇨🇳🇨🇭🇫🇮🇳🇿🇸🇪🇲🇨🇸🇦
Let by Mik Wetterslev now PhD in the topic
Funded by Rigshospitalet
A coming trial topic for CRIC INCEPT

New version of our 'adaptr' R package on CRAN including important new functionality (trial calibration) and other improvements - see inceptdk.github.io/adaptr/ and thread below if you're interested in simulation of complex adaptive trial designs. 1/..

Are days alive without life support/out of hospital (DAWOLS/DAOOH) associated with longer-term health-related quality of life (HRQoL)?
We aimed to find out - new article online (OA), doi.org/10.1111/aas.14…, conducted as part of the INCEPT programme.
1/..

Version 1.2.0 of the 'adaptr' R package for simulating adaptive clinical trials with adaptive stopping, arm dropping and randomisation on CRAN; details at: inceptdk.github.io/adaptr/ w/ Benjamin Skov Kaas-Hansen Theis Lange Aksel KG Jensen INCEPT 1/..

Now online in Journal of Clinical Epidemiology (OA): jclinepi.com/article/S0895-…
In this manuscript we provide an overview of the key methodological considerations for (multi-arm, multi-stage) clinical trials using adaptive stopping, arm dropping, and randomisation with a worked example. Details below 1/

How are patient-important outcomes other than mortality handled in ICU trials?

Anders Granholm et al. call for ⬆️ focus on standardizing outcome choices, adequate handling of missing data and deceased patients in analyses, and use of statistical methods quantifying effect sizes.

#causalinference from #ICU #secondarydata could inform and guide critical care #RCTs . But is it used? We're setting out to find out: doi.org/10.1111/aas.14… INCEPT

New paper in Critical Care Medicine: to inform selection and handling of patient-important outcomes other than mortality in INCEPT, we conducted a scoping review summarising selection, definition, and handling of these outcomes in contemporary ICU trials (1/..) doi.org/10.1097/ccm.00…

Minor update to the 'adaptr' R package for adaptive trial simulation now available on CRAN (cran.r-project.org/web/packages/a…). Details on the package available below and on inceptdk.github.io/adaptr/. INCEPT Benjamin Skov Kaas-Hansen Theis Lange

This week, the INCEPT programme received the ‘Innovation of the year’-award in the first Danish awards ceremony for clinical trials. We are proud and highly motivated to continue our work on establishing the INCEPT platform trial! Coverage (in Danish): dagensmedicin.dk/syv-glade-vind…

We have a paper on our 'adaptr' R-package for adaptive trial simulation and comparison (developed as part of the INCEPT project) published in JOSS joss.theoj.org/papers/10.2110….
The package is documented on a stand-alone website at inceptdk.github.io/adaptr/. (1/6)

Just published in JOSS: '`adaptr`: an R package for simulating and comparing adaptive clinical trials' doi.org/10.21105/joss.…

Now also available on CRAN: cran.r-project.org/web/packages/a…