Centre for Medicines Discovery
@CmdOxford
A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.
ID:1281511219413876738
https://www.cmd.ox.ac.uk/ 10-07-2020 08:51:45
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ACS Publications Bio & Med Chem Content New scaffold to explore ADP-ribose metabolism: By performing SAR studies, we identify a first-in-class, non-covalent dual inhibitor for NUDT5 and NUDT14. (5/5)
📖Read the full story here: pubs.acs.org/doi/10.1021/ac…
#CovalentInhibitors #ChemicalProbes #DarkProteome
The Bullock lab at Centre for Medicines Discovery together with Ontario Institute for Cancer Research (OICR) and M4K Pharma report in J Med Chem the Discovery of Conformationally Constrained ALK2 Inhibitors aimed at future treatments for the childhood brain tumour DIPG. Congratulations Julien Cros, Jong Fu Wong and Dr Melissa Sweeney
🎉The Chemical Probes Portal has reached 1,000 compounds!
We review hundreds of high-quality protein inhibitors and other tools for biomedical research, as well as 255 Unsuitables.
Read more:
chemicalprobes.org/news/1000-comp…
#OpenScience #DrugDiscovery #TPD #degraders #ChemicalProbes
Congratulations to team PROTECT, including our own Prof Frank von Delft, on receiving the Cancer Grand Challenges Challenges award! They're tackling the tough challenge of #SolidTumours in children Cancer Research UK, National Cancer Institute
cmd.ox.ac.uk/news/research-…
New publication on the structure and allosteric regulation of Alzheimer’s target SHIP1 from Will Bradshaw, Opher Gileadi, Oxford Drug Discovery Institute, Kavli Institute for Nanoscience Discovery, Oxford. Including an XChem fragment screen with 91 structures.
authors.elsevier.com/sd/article/S09…
The Bullock lab @CMDOxford and Wilkie Lab Wilkie Lab report a new paper identifying mutations in the BTB domain of KCTD15 that perturb BTB oligomerisation and cause a distinctive frontonasal dysplasia syndrome DOI: doi.org/10.1136/jmg-20…
The Katharina L. Duerr and David B Sauer group's new publication reveals export of immunoregulatory sphingosine-1-phosphate is regulated by the signaling lipid PIP2 via its action on the transporter SPNS2. doi.org/10.1016/j.molc…
The Centre for Medicines Discovery team in New York this week for the ASAP Discovery meeting. What a privilege to at last hang out with the people in person we were in the trenches with since COVID Moonshot. And getting to know all the new people joining our pandemic preparedness effort.
Congratulations to all CMD team members of the COVID Moonshot collaboration that was awarded the 2nd place in the SCI innovation award! Great to see the project recognised amongst a very competitive field at a ceremony in the Palace of Westminster last Wednesday.
Join us for the upcoming Target 2035 #webinar to expand your knowledge and contribute to the advancement of best practices for #chemicalprobes .
Mark your 📅 and register for #free : bit.ly/3MAAobz
WEHI (Walter and Eliza Hall Institute), Cell Signalling Laboratory, University of Sydney,
DrugDiscoveryInitiative, Nature Communications
The Bullock lab @CMDOxford has a new paper on KEAP1-CUL3 structure, TR-FRET and inhibition by CDDO. Great collaboration with Ralph Mazitschek Ralph Mazitschek DOI: doi.org/10.1016/j.free…
Register now for Target 2035's upcoming webinar on February 21 and learn all you need for XChem, a dedicated platform for crystallographic fragment screening. Daren Fearon Diamond Light Source Lizbe Koekemoer Centre for Medicines Discovery @EubOPEN bit.ly/3jBYlU6
Wonderful to welcome 20 of جامعة الملك عبدالعزيز‘s brightest students to Oxford for two weeks during the annual CAIPM Summer Exchange programme to learn about AI and drug discovery. Congratulations to Ola and Tahani for winning the award for best presentation on target tractability!
