The future of gut microbiome manipulation in medicine laid out here is remarkable
sciencedirect.com/science/articl… William Fusco ElinavLab Gianluca Ianiro Giovanni Cammarota Hugh Thomas The Lancet Gastroenterology & Hepatology

Fertility, pregnancy, and childbirth are pivotal life events that are affected by inflammatory bowel disease (IBD).

A seminar provides the latest evidence regarding issues to be considered for optimal pregnancy outcomes in people with IBD: hubs.li/Q02r29MQ0

Here is the summary of new eligibility criteria for treatment of #HBV from the new ⁦World Health Organization (WHO)⁩ guidelines. HBV >2000 and ALT >ULN will encompass most of patients in our clinics. IMO patient choice still critical. ⁦Hep B Foundation⁩ ⁦British Liver Trust⁩ ⁦ICE-HBV⁩

“There are lots of ways you can eliminate preauthorization from procedures without affecting more than 1% or 2% of the total number of required prior authorizations”-Dr. Bruce Hennessy, ASGE Health & Public Policy Committee Chair. Full comments: hubs.ly/Q02qqDP90 #GITwitter

New Review - Sharif et al - Ecogastroenterology: cultivating sustainable clinical excellence in an environmentally conscious landscape

thelancet.com/journals/langa…

#GITwitter Ian M. Gralnek MD, MSHS, FESGE, FASGE Shomron Ben-Horin

New paper 'Alcohol consumption and the risk of all-cause and cause-specific mortality—a linear and nonlinear Mendelian randomization study' at IJE: academic.oup.com/ije/article/53… led by Nigussie Kassaw and Elina Hyppönen. Brief thread:

There is so much to value in these brilliant 45 mins:
-The multitude benefits from Bayesian sequential trials
- Sample size calculation voodoo
- The waste of binary time-to-event outcomes and strength of high-res, high-info outcomes
- Free power from covariate adjustment

Video of yesterday's talk for Consilium Scientific on making clinical trials more efficient is now available: youtu.be/FI2ncRU9PPQ?si… #clinicaltrials #Statistics Vanderbilt Department of Biostatistics

Shocked, shocked to find that fewer international students means fewer, not more, places for British kids, exactly as predicted by anyone who understood the issues ..

A drug for NASH/MASH fibrosis is a fantastic achievement. Getting that drug to all people who will really benefit, rather than just those who can pay, will be an even more fantastic achievement

NEJM has not one, but two studies on colorectal cancer screening that report only sensitivity and specificity of a new test. I have zero idea how to interpret the results: are they good tests or bad? #ClinicallyRelevantStatistics nejm.org/doi/full/10.10…

The uncertainty for these scary estimates of overall early-onset cancer incidence is *extremely* wide in the original paper—a shame this important nuance is lost in both post and article (the estimated sharp incidence jump in 2020 also unexplained?)

Thank you Hugh Thomas for the invitation and the opportunity to revisit the story of how the project started last summer at the EASL School on alcohol-related liver disease.

Great people, great meeting.

EASL Education EASLnews
Ramon Bataller Aleksander Krag Maja Thiele

Honoured to chat with Mads Israelsen for this episode, on a hot topic that has been consuming a good part of the hepatology world for a number of years!

What's the prognostic information conveyed by the #MASLD , #MetALD and #ALD nomenclature in people drinking excess 🍺🍷?

This Women's History Month, we celebrate women leading the charge for #hep elimination! 💐 We recognize Dr. Manal El-Sayed & Dr. Wendy Spearman.

More on Dr. El-Sayed: buff.ly/3uXC0pV
More on Dr. Spearman: buff.ly/3T5yv8M
More on SOLDA: buff.ly/48SjahW

On #InternationalWomensDay a thread of Profiles in The Lancet highlighting the work and lives of 4 women in health, medicine, and research 🧵

On the cover (by the wonderful Mempathie_Illustration) — the updated Commission on progress towards elimination of viral #hepatitis , exploring the changing situation in the top 20 most burdened countries since 2018
thelancet.com/journals/langa…

New🎙️

@LouiseDye discusses an RCT on effects of #gluten and expectancy in non-coeliac gluten sensitivity

- role of gluten + nocebo effects
- how to design a nocebo trial?
- what does it mean for patients?

🔊buzzsprout.com/1728646/146082…
📜thelancet.com/journals/langa… #GITwitter

ICYMI - Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study
thelancet.com/journals/langa…

#LiverTwitter #SLD #MASLD #NAFLD Mads Israelsen

Worthy efforts to improve food and food systems risk susbtantial side-effects, and as always those will be felt worst by least privileged
I particularly like the final lines here👇