A combination of biochemical, structural, and modeling studies identifies OSM-S-106 as an exemplar of a new chemical class of species-specific reaction hijacking inhibitors. Matthew Todd

#malaria #AntimalariaResearch #DrugDiscovery

Read more: nature.com/articles/s4146…

Interested in synthesis and synthesis prediction? Steve Marsden and I have a PhD studentship that is collaborative with Exscientia. Enhanced stipend. Open to UK students (and, in competition, to international applicants) phd.leeds.ac.uk/project/1706-d…

Deeply fun to welcome students from Whitgift School to UCL School of Pharmacy UCL Faculty of Life Sciences to analyse samples of a molecule they made for the #openscience drug discovery project Open Source Mycetoma We NMR'd, we mass specced, we figured it out. ucl.ac.uk/pharmacy/news/… Research in Schools

Love #orgchem ? Love palladium catalysis? Love the Miyaura borylation? We do, but there's one we can't get working. We need it to enable high value compounds for #malaria in Open Source Malaria. See github.com/OpenSourceMala… for more. #openscience Yinuo Wang Medicines for Malaria Venture (MMV) Structural Genomics Consortium (SGC)

John Moult kicking off the CACHE Challenge Symposium in Toronto, describing the lessons learned from the CASP protein structure prediction competition Structural Genomics Consortium (SGC)

Yesterday's board dinner of Structural Genomics Consortium (SGC) at University of Toronto Faculty Club with aled edwards Levon Matthieu Schapira Ryan Merkley 🍁 Rachel Harding Cheryl Arrowsmith (& others not on X..). Such a fun group of talented researchers who advocate, and *do*, #openscience .

Fragments and #openscience ftw! We've 18 frags bound at the interface of SARS-CoV-2 Nsp10 and Nsp14, and now we need to grow/merge/link. Details at github.com/StructuralGeno… Live and online at Fragalysis fragalysis.diamond.ac.uk/viewer/react/p… We can buy/make/measure. Structural Genomics Consortium (SGC) #antiviral

An #openscience project needing community help from computational modellers. WDR91 for host-directed antivirals. We've binders + xstal structure. We need to understand the data, particularly the matched pairs. github.com/StructuralGeno… Structural Genomics Consortium (SGC) Target 2035 UCL Faculty of Life Sciences

Several #openscience projects in the lab are nicely poised for community inputs. Here's a peach. One of the Structural Genomics Consortium (SGC) Open Chemistry Networks needs some simple ureas. You make, we test. Protocols available. github.com/StructuralGeno… Target 2035 UCL Faculty of Life Sciences

Well done Yinuo Wang! #openscience #malaria #DrugDiscovery

Interesting thread from Ingo Hartung. Exceptions both ways. Were the crazy stories representative? Uni medchem groups can be extraordinarily secretive/competitive. But the culture comment is familiar and makes us PIs to reflect on how best to do things now.

Well done Yinuo Wang! UCL School of Pharmacy

Awesome that this is out nature.com/articles/s4146… We'd paused this Open Source Malaria series because of SAR cliffs. Beautiful work by Leann Tilley Dr. Elizabeth A Winzeler & teams shows a 'reaction hijacking' mechanism, which is too cool + shows way forward. Thank you Medicines for Malaria Venture (MMV) for support.

Mycetoma is a devastating skin disease that can lead to stigma, disability and amputation. No proper medications are available. The #openscience group Open Source Mycetoma is seeking novel drugs for #mycetoma and you can help. Join us github.com/OpenSourceMyce… #WorldNTDDay Drugs for Neglected Diseases initiative

I work with the #openscience community Open Source Mycetoma to find new medicines to treat #mycetoma , a neglected tropical fungal infection. Meetings are shown at github.com/OpenSourceMyce…. Join in! The molecule below has just shown promise and needs investigating #WorldNTDDay Drugs for Neglected Diseases initiative

With Dr Evans Mainsah, University of Buea, Cameroon University of Buea. Evans is a BVGH Africa Research Excellence Fund Fellow in my lab this year seeking new drugs to treat onchocerciasis (river blindness). #WorldNTDDay

Ten days til the London NMR Forum restarts - 5pm Thursday 25th Jan The Crick.

Don't forgot to register (free) at londonnmr.wordpress.com. We've also added a sign-up link for a new mailing list to keep up to date with upcoming meetings. #nmrchat #londonnmr

Two protein science positions available at UCL to work on big, cool new venture with me + Structural Genomics Consortium (SGC): Grade 8, Senior Scientist (ucl.ac.uk/work-at-ucl/se…) and Grade 6 Technician (ucl.ac.uk/work-at-ucl/se…) aled edwards Target 2035 Interviews Jan 29th, must start early Feb.

First Annual CACHE Symposium: March 6-7 in Toronto. Talks from John Moult, Michael K Gilson, CACHE #1 participants Christina Schindler, David Koes, Olexandr Isayev 🇺🇦🇺🇸 and many more. To register or submit a poster: bit.ly/3uLGTlh #compchem

Lovely talk yesterday at UCL School of Pharmacy from Tim Willson giving overview of Structural Genomics Consortium (SGC) UNC Pharmacy research in drugging understudied proteins. Target 2035 Included v nice story of basic research --> open probe --> obeticholic acid/Ocaliva helping patients.