A comprehensive protocol for measuring targeted protein degradation using NanoLuciferase and HaloTag-based screening technologies.

Read more: nature.com/articles/s4159…

Joint efforts of industry and academic researchers results in the development of a standardized #antibodycharacterization protocol, now available for all to use!  ⏩doi.org/10.21203/rs.3.…

Our recent review delves into recent advancements involving E3 ligases and addresses the technical challenges of developing effective PROTACs. Can these emerging degraders compete with established degrader systems?
Find out🔽 sciencedirect.com/science/articl…

A new radiometric assay for human mRNA guanine-N7 methyltransferase (RNMT) not only clarifies RNMT's kinetic parameters but is also designed for high-throughput screening.
Explore the full details of our study: nature.com/articles/s4159…

10 leading antibody manufacturers, YCharOS and Structural Genomics Consortium (SGC) team up to agree on a (reagent) antibody characterization platform/protocol. If more folks adopt this, we’d be well on our way to more reproducible biomedical research!

protocolexchange.researchsquare.com/article/pex-26…

Preliminary results for CACHE #4 are out: 1688 compounds predicted by 23 participants to bind the TKB domain of CBLB were tested. 10 bind CBLB and not an unrelated target. 9 participants advance to Round 2: hit expansion. bit.ly/3vOCFKB Structural Genomics Consortium (SGC) Conscience

A new study developed biochemical and biophysical assays to identify molecules that disrupt a process linked to #Alzheimer 's disease.
Read more: journals.plos.org/plosone/articl…

A combination of biochemical, structural, and modeling studies identifies OSM-S-106 as an exemplar of a new chemical class of species-specific reaction hijacking inhibitors. Matthew Todd

#malaria #AntimalariaResearch #DrugDiscovery

Read more: nature.com/articles/s4146…

SGC's success across all six research sites is largely due to the hard work and dedication of our #graduatestudents . We asked our Principal Investigators to share their thoughts about how graduate students have been pivotal to their team.

At SGC, we often share with peers but rarely meet the patients we serve. Thanks to Dalia Barsyte, a special #patientoutreach visit, supported by Leukemia & Lymphoma Society of Canada, brought new insights.
Full story: thesgc.org/node/1649774
#LeukemiaResearch #BeyondTheBench

A re-evaluation of literature compounds and structure-guided design was used to optimize the p21-activated kinase inhibitor to selectively target MST3/4.
pubs.acs.org/doi/10.1021/ac…

We are thrilled to welcome Hui Peng to lead the development and scaling of the ASMS screening platform. This appointment will enable SGC at Temerty Medicine to establish itself as one of the few academic research hubs worldwide with ASMS screening capacity.
thesgc.org/news/toronto/s…

📢 Agora Open Science Trust is looking for a Vice President, Drug Discovery and Development. This is a great opportunity to work on a first-of-its-kind #openscience drug development initiative targeting pediatric brain cancer.
Apply: linkedin.com/jobs/view/3864…
#jobopportunity #drugdiscovery

A dual-targeting strategy revealed a promising new drug target for DENV therapy.
The SGC Frankfurt
biorxiv.org/content/10.110…

More high-quality data in the open is needed to enable computational drug discovery efforts. To make this happen, we are working with X-Chem and harnessing their DNA-Encoded Library (DEL) platform.
#DrugDiscovery #OpenScience #DEL #AI

x-chemrx.com/x-chem-and-the…